Related Readings – Monday Lecture – Nathaniel Heintz, Ph.D.


Addressing Brain Complexity

Monday, April 30, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Review Article

Hatten, M. E. and Heintz, N. (2005).Large-scale genomic approaches to brain development and circuitry. Annual Review of Neuroscience 28:89-108.

Related Articles

Anthony, T. E., Mason, H. A., Gridley, T., Fishell, G. and Heintz, N. (2005). Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes & Development 19:1028-1033.
Gong, S. C., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E. and Heintz, N. (2003). A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature 425:917-925.
Heintz, N. (2001). Bac to the future: The use of bac transgenic mice for neuroscience research. Nature Reviews Neuroscience 2:861-870.
Miwa, J. M., Stevens, T. R., King, S. L., Caldarone, B. J., Ibanez-Tallon, I., Cheng, X., Fitzsimonds, R. M., Pavildes, C., Lester, H. A., Picciotto, M. R. and Heintz, N. (2006). The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron 51:587-600.
Wang, Q. J., Ding, Y. M., Kohtz, S., Mizushima, N., Cristea, I. M., Rout, M. P., Chait, B. T., Zhong, Y., Heintz, N. and Yue, Z. Y. (2006). Induction of autophagy in axonal dystrophy and degeneration. Journal of Neuroscience 26:8057-8068.

Related Readings – Friday Lecture – Phillip A. Sharp, Ph.D.

Small RNAs as a Window on Gene Regulation

Friday, April 27, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Bartel, D.P. (2004).MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116:281-297.

Related Articles

Dykxhoorn, D.M., Novina, C.D. and Sharp, P.A. (2003).Killing the messenger: Short RNAs that silence gene expression. Nature Reviews Molecular Cell Biology 4:457-467.
Neilson, J.R., Zheng, G.X.Y., Burge, C.B. and Sharp, P.A. (2007).Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes & Development 21:578-589.
Petersen, C.P., Bordeleau, M.E., Pelletier, J. and Sharp, P.A. (2006).Short RNAs repress translation after initiation in mammalian cells. Molecular Cell 21:533-542.
Zamore, P.D. and Haley, B. (2005).Ribo-gnome: The big world of small RNAs. Science 309:1519-1524.

Related Readings – Monday Lecture – Titia de Lange Ph.D.


How telomeres deal with the DNA damage response

Monday, April 23, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Overview Article

de Lange, T. (Article Online Posting Date: September 23, 2005).Telomeres: Protection and Maintenance. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd.

Related Articles

Celli, G. B. and de Lange, T. (2005).DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nature Cell Biology 7:712-U110.
de Lange, T. (2004).T-loops and the origin of telomeres. Nature Reviews Molecular Cell Biology 5:323-329.
de Lange, T. (2005).Shelterin: the protein complex that shapes and safeguards human telomeres. Genes & Development 19:2100-2110.
d’Adda di Fagagna, F., Teo, S. H. and Jackson, S. P. (2004). Functional links between telomeres and proteins of the DNA-damage response. Genes & Development 18:1781-1799.
Dimitrova, N. and de Lange, T. (2006).MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes & Development 20:3238-3243.

Related Readings – Friday Lecture – Alexander Rudensky Ph.D.


Dominant Tolerance

Friday, April 20, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Related Articles

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A. and Rudensky, A. Y. (2007).Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445:771-775.
Kim, J. M. and Rudensky, A. (2006).The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunological Reviews 212:86-98.
Sakaguchi, S., Ono, M., Setoguchi, R., Yagi, H., Hori, S., Fehervari, Z., Shimizu, J., Takahashi, T. and Nomura, T. (2006).Foxp3(+)CD25(+)CD4(+) natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunological Reviews 212:8-27.
Schwartz, R. H. (2005).Natural regulatory T cells and self-tolerance. Nature Immunology 6:327-330.

Related Readings – Monday Lecture – Magda Konarska, Ph.D.


Conformational dynamics during pre-mRNA splicing and their impact on fidelity

Monday, April 16, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Overview Article

Newman, A. (Article Online Posting Date: September 23, 2005).Splicing of pre-mRNA. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. See also Splice Sites, SR Proteins, Spliceosome, mRNA Splicing: Role of snRNAs.

Related Articles

Konarska, M. M. and Query, C. C. (2005).Insights into the mechanisms of splicing: more lessons from the ribosome. Genes & Development 19:2255-2260.
Konarska, M. M., Vilardell, J. and Query, C. C. (2006).Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Molecular Cell 21:543-553.
Mayas, R. M., Maita, H. and Staley, J. P. (2006).Exon ligation is proofread by the DExD/H-box ATPase Prp22p. Nature Structural & Molecular Biology 13:482-490.
Query, C. C. and Konarska, M. M. (2006).Splicing fidelity revisited. Nature Structural & Molecular Biology 13:472-474.

Related Readings – Friday Lecture – Michael Meaney Ph.D.


Epigenetic programming of gene expresssion and stress responses through variations in maternal care

Friday, April 13, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m.
Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Cameron, N. M., Champagne, F. A., Fish, Cpew, Ozaki-Kuroda, K. and Meaney, M. J. (2005).The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care. Neuroscience and Biobehavioral Reviews 29:843-865.

Related Articles

Fish, E. W., Shahrokh, D., Bagot, R., Caldji, C., Bredy, T., Szyf, M. and Meaney, M. J. (2004).Epigenetic programming of stress responses through variations in maternal care. Ann. NY Acad. Sci. 1036:167-180.
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D’Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M. and Meaney, M. J. (2004).Epigenetic programming by maternal behavior. Nature Neuroscience 7:847-854.
Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J. and Szyf, M. (2005).Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life. Journal of Neuroscience 25:11045-11054.
Weaver, I. C. G., D’Alessio, A. C., Brown, S. E., Hellstrom, I. C., Dymov, S., Sharma, S., Szyf, M. and Meaney, M. J. (2007).The transcription factor nerve growth factor-inducible protein A mediates epigenetic programming: Altering epigenetic marks by immediate-early genes. Journal of Neuroscience 27:1756-1768.
Weaver, I. C. G., Meaney, M. J. and Szyf, M. (2006).Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proceedings of the National Academy of Sciences of the United States of America 103:3480-3485.

Related Readings – Monday Lecture – Peter Mombaerts, Ph.D.

Odorant Receptor Gene Choice

Monday, April 9, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Review Article

Mombaerts, P. (2006).Axonal wiring in the mouse olfactory system. Annual Review of Cell and Developmental Biology 22:713-737.

Related Articles

Feinstein, P. and Mombaerts, P. (2004).A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell 117:817-831.

Li, J. S., Ishii, T., Feinstein, P. and Mombaerts, P. (2004).Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature 428:393-399.
Serizawa, S., Miyamichi, K., Nakatani, H., Suzuki, M., Saito, M., Yoshihara, Y. and Sakano, H. (2003).Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 302:2088-2094.
Zhang, X. M., Rodriguez, I., Mombaerts, P. and Firestein, S. (2004).Odorant and vomeronasal receptor genes in two mouse genome assemblies. Genomics 83:802-811.

Related Readings – The Wiley Prize in Biomedical Sciences

Understanding Protein Folding in the Cell – F. Ulrich Hartl, M.D.
Chaperonin-Mediated Protein Folding – Arthur L. Horwich, M.D.

Friday, April 6, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Overview Article

Ellis, R. John and Hartl, F. Ulrich. (Article Online Posting Date: January 27, 2006).Protein folding and chaperones. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd.

Related Articles

Barral, J. M., Broadley, S. A., Schaffar, G. and Hartl, F. U. (2004).Roles of molecular chaperones in protein misfolding diseases. Seminars in Cell & Developmental Biology 15:17-29.
Bukau, B., Weissman, J. and Horwich, A. (2006).Molecular chaperones and protein quality control. Cell 125:443-451.
Hartl, F. U. (1996).Molecular chaperones in cellular protein folding. Nature 381:571-580.
Horwich, A. L., Farr, G. W. and Fenton, W. A. (2006).GroEL-GroES-mediated protein folding. Chemical Reviews 106:1917-1930.
Park, E. S., Fenton, W. A. and Horwich, A. L. (2007).Disulfide formation as a probe of folding in GroEL-GroES reveals correct formation of long-range bonds and editing of incorrect short-range ones. Proceedings of the National Academy of Sciences of the United States of America 104:2145-2150.
Young, J. C., Agashe, V. R., Siegers, K. and Hartl, F. U. (2004).Pathways of chaperone-mediated protein folding in the cytosol. Nature Reviews Molecular Cell Biology 5:781-791.