Related Readings – Friday Lecture – Leonard P. Guarante, Ph.D.

Sirtuins, Calorie Restriction and Disease

Friday, March 16, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Haigis, M. C. and Guarente, L. P. (2006).Mammalian sirtuins – emerging roles in physiology, aging, and calorie restriction. Genes & Development 20:2913-2921.

Related Articles

Guarente, L. (2006).Sirtuins as potential targets for metabolic syndrome. Nature 444:868-874.
Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Weindruch, R., Alt, F. W. and Guarente, L. (2006).SIRT4 inhibits glutamate dehydrogehase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126:941-954.
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P. F., Mostoslavsky, G., Franco, S., Murphy, M. M., Mills, K. D., Patel, P., Hsu, J. T., Hong, A. L., Ford, E., Cheng, H. L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M. O., Hursting, S., Barrett, J. C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G. D. and Alt, F. W. (2006).Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124:315-329.
Picard, F., Kurtev, M., Chung, N. J., Topark-Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M., McBurney, M. W. and Guarente, L. (2004).Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429:771-776.
Sauve, A. A., Wolberger, C., Schramm, V. L. and Boeke, J. D. (2006).The biochemistry of sirtuins. Annual Review of Biochemistry 75:435-465.