Related Readings – Monday Lecture – Charalampos Spilianakis, Ph.D.

Interchromosomal Interactions: Positive and Negative Regulators of Gene Expression

Monday, March 5, 2007
Welch Hall (2nd Floor)

3:45 p.m. Refreshments 4:00 p.m. Lecture

Recommended Review Article

Ansel, K. M. and Djuretic, I. and Tanasa, B. and Rao, A. (2006).Regulation of Th2 differentiation and Il4 locus accessibility. Annual Review of Immunology 24:607-656.

Related Articles

Cha, R. S. and Weiner, B. M. and Keeney, S. and Dekker, J. and Kleckner, N. (2000).Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p. Genes & Development 14:493-503.
Lee, G. R. and Kim, S. T. and Spilianakis, C. G. and Fields, P. E. and Flavell, R. A. (2006).T helper cell differentiation: Regulation by cis elements and epigenetics. Immunity 24:369-379.
Spilianakis, C. G. and Flavell, R. A. (2004).Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nature Immunology 5:1017-1027.
Spilianakis, C. G. and Lalioti, M. D. and Town, T. and Lee, G. R. and Flavell, R. A. (2005).Interchromosomal associations between alternatively expressed loci. Nature 435:637-645.
Spilianakis, C. and Papamatheakis, J. and Kretsovali, A. (2000).Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Molecular and Cellular Biology 20:8489-8498.
van Overveld, P. G. M. and Lemmers, Rjfl and Deidda, G. and Sandkuijl, L. and Padberg, G. W. and Frants, R. R. and van der Maarel, S. M. (2000).Interchromosomal repeat array interactions between chromosomes 4 and 10: a model for subtelomeric plasticity. Human Molecular Genetics 9:2879-2884.
Xu, N. and Tsai, C. L. and Lee, J. T. (2006).Transient homologous chromosome pairing marks the onset of X inactivation. Science 311:1149-1152.

Related Readings – Friday Lecture – Jeffrey Friedman Ph.D.

Leptin, Behavior & Metabolism: Balancing the Energy Equation/in vivo/

Friday, March 2, 2007

Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge

Recommended Review Article

Spiegelman, B. M. and Flier, J. S. (2001).Obesity and the regulation of energy balance. Cell 104:531-543.

Related Articles

Cohen, P. and Miyazaki, M. and Socci, N. D. and Hagge-Greenberg, A. and Liedtke, W. and Soukas, A. A. and Sharma, R. and Hudgins, L. C. and Ntambi, J. M. and Friedman, J. M. (2002).Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297:240-243.
Cowley, M. A. and Smart, J. L. and Rubinstein, M. and Cordan, M. G. and Diano, S. and Horvath, T. L. and Cone, R. D. and Low, M. J. (2001).Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484.
Cowley, M. A. and Smith, R. G. and Diano, S. and Tschop, M. and Pronchuk, N. and Grove, K. L. and Strasburger, C. J. and Bidlingmaier, M. and Esterman, M. and Heiman, M. L. and Garcia-Segura, L. M. and Nillni, E. A. and Mendez, P. and Low, M. J. and Sotonyi, P. and Friedman, J. M. and Liu, H. Y. and Pinto, S. and Colmers, W. F. and Cone, R. D. and Horvath, T. L. (2003).The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661.
Ellacott, K. L. J. and Cone, R. D. (2006).The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philosophical Transactions of the Royal Society B-Biological Sciences 361:1265-1274.
Friedman, J. M. and Halaas, J. L. (1998).Leptin and the regulation of body weight in mammals. Nature 395:763-770.
Heisler, L. K. and Jobst, E. E. and Sutton, G. M. and Zhou, L. G. and Borok, E. and Thornton-Jones, Z. and Liu, H. Y. and Zigman, J. M. and Balthasar, N. and Kishi, T. and Lee, C. E. and Aschkenasi, C. J. and Zhang, C. Y. and Yu, J. and Boss, O. and Mountjoy, K. G. and Clifton, P. G. and Lowell, B. B. and Friedman, J. M. and Horvath, T. and Butler, A. A. and Elmquist, J. K. and Cowley, M. A. (2006).Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 51:239-249.
Pinto, S. and Roseberry, A. G. and Liu, H. Y. and Diano, S. and Shanabrough, M. and Cai, X. L. and Friedman, J. M. and Horvath, T. L. (2004).Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304:110-115.