Chromosome Choreography: The Meiotic Pas de Deux
Friday, March 23, 2007
Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge
Recommended Review Article
Pawlowski, W. P. and Cande, W. Z. (2005).Coordinating the events of the meiotic prophase. Trends in Cell Biology 15:674-681.
Monday, March 12, 2007
Monday, March 5, 2007
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Couteau, F., Nabeshima, K., Villeneuve, A. and Zetka, M. (2004).A component of C-elegans meiotic chromosome axes at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination. Current Biology 14:585-592.
Macqueen, A. J., Phillips, C. M., Bhalla, N., Weiser, P., Villeneuve, A. M. and Dernburg, A. F. (2005).Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans. Cell 123:1037-1050.
Page, S. L. and Hawley, R. S. (2003).Chromosome choreography: The meiotic ballet. Science 301:785-789.
Phillips, C. M. and Dernburg, A. F. (2006).A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans. Developmental Cell 11:817-829.
Phillips, C. M., Wong, C., Bhalla, N., Carlton, P. M., Weiser, P., Meneely, P. M. and Dernburg, A. F. (2005).HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis. Cell 123:1051-1063.
Related Readings – Friday Lecture – Leonard P. Guarante, Ph.D.
Sirtuins, Calorie Restriction and Disease
Friday, March 16, 2007
Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge
Recommended Review Article
Haigis, M. C. and Guarente, L. P. (2006).Mammalian sirtuins – emerging roles in physiology, aging, and calorie restriction. Genes & Development 20:2913-2921.
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Guarente, L. (2006).Sirtuins as potential targets for metabolic syndrome. Nature 444:868-874.
Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Weindruch, R., Alt, F. W. and Guarente, L. (2006).SIRT4 inhibits glutamate dehydrogehase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126:941-954.
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P. F., Mostoslavsky, G., Franco, S., Murphy, M. M., Mills, K. D., Patel, P., Hsu, J. T., Hong, A. L., Ford, E., Cheng, H. L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M. O., Hursting, S., Barrett, J. C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G. D. and Alt, F. W. (2006).Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124:315-329.
Picard, F., Kurtev, M., Chung, N. J., Topark-Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M., McBurney, M. W. and Guarente, L. (2004).Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429:771-776.
Sauve, A. A., Wolberger, C., Schramm, V. L. and Boeke, J. D. (2006).The biochemistry of sirtuins. Annual Review of Biochemistry 75:435-465.
Related Readings – Monday Lecture – Christine Dunham, Ph.D.
Structural Studies of the 70S Ribosome
Monday, March 12, 2007
Welch Hall (2nd Floor)
3:45 p.m. Refreshments 4:00 p.m. Lecture
Recommended Review Article
Ramakrishnan, V. (2002).Ribosome structure and the mechanism of translation. Cell 108:557-572.
Related Articles
Korostelev, A. and Trakhanov, S. and Laurberg, M. and Noller, H. F. (2006).Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements. Cell 126:1065-1077.
Mitra, K. and Frank, J. (2006).Ribosome dynamics: Insights from atomic structure modeling into cryo-electron microscopy maps. Annual Review of Biophysics and Biomolecular Structure 35:299-317.
Petry, S. and Brodersen, D. E. and Murphy, F. V. and Dunham, C. M. and Selmer, M. and Tarry, M. J. and Kelley, A. C. and Ramakrishnan, V. (2005).Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon. Cell 123:1255-1266.
Schuwirth, B. S. and Borovinskaya, M. A. and Hau, C. W. and Zhang, W. and Vila-Sanjurjo, A. and Holton, J. M. and Cate, J. H. D. (2005).Structures of the bacterial ribosome at 3.5 angstrom resolution. Science 310:827-834.
Selmer, M. and Dunham, C. M. and Murphy, F. V. and Weixlbaumer, A. and Petry, S. and Kelley, A. C. and Weir, J. R. and Ramakrishnan, V. (2006).Structure of the 70S ribosome complexed with mRNA and tRNA. Science 313:1935-1942.
Related Readings – Friday Lecture – Leslie Vosshall, Ph.D.
Olfaction: From Receptors to Perception
Friday, March 9, 2007
Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge
Recommended Review Article
Bargmann, C. I. (2006).Comparative chemosensation from receptors to ecology. Nature 444:295-301.
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Benton, R. and Sachse, S. and Michnick, S. W. and Vosshall, L. B. (2006). Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. PLoS Biology 4:240-257.
Couto, A. and Alenius, M. and Dickson, B. J. (2005).Molecular, anatomical, and functional organization of the Drosophila olfactory system. Current Biology 15:1535-1547.
Fishilevich, E. and Vosshall, L. B. (2005).Genetic and functional subdivision of the Drosophila antennal lobe. Current Biology 15:1548-1553.
Hallem, E. A. and Ho, M. G. and Carlson, J. R. (2004).The molecular basis of odor coding in the drosophila antenna. Cell 117:965-979.
Jones, W. D. and Cayirlioglu, P. and Kadow, I. G. and Vosshall, L. B. (2007).Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. Nature 445:86-90.
Keller, A. and Vosshall, L.B. (2003).Decoding olfaction in Drosophila. Current Opinion in Neurobiology 13:103-110.
Kreher, S. A. and Kwon, J. Y. and Carlson, J. R. (2005).The molecular basis of odor coding in the Drosophila larva. Neuron 46:445-456.
Malnic, B. and Godfrey, P. A. and Buck, L. B. (2004).The human olfactory receptor gene family. Proceedings of the National Academy of Sciences of the United States of America 101:2584-2589.
Related Readings – Monday Lecture – Charalampos Spilianakis, Ph.D.
Interchromosomal Interactions: Positive and Negative Regulators of Gene Expression
Monday, March 5, 2007
Welch Hall (2nd Floor)
3:45 p.m. Refreshments 4:00 p.m. Lecture
Recommended Review Article
Ansel, K. M. and Djuretic, I. and Tanasa, B. and Rao, A. (2006).Regulation of Th2 differentiation and Il4 locus accessibility. Annual Review of Immunology 24:607-656.
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Cha, R. S. and Weiner, B. M. and Keeney, S. and Dekker, J. and Kleckner, N. (2000).Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p. Genes & Development 14:493-503.
Lee, G. R. and Kim, S. T. and Spilianakis, C. G. and Fields, P. E. and Flavell, R. A. (2006).T helper cell differentiation: Regulation by cis elements and epigenetics. Immunity 24:369-379.
Spilianakis, C. G. and Flavell, R. A. (2004).Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nature Immunology 5:1017-1027.
Spilianakis, C. G. and Lalioti, M. D. and Town, T. and Lee, G. R. and Flavell, R. A. (2005).Interchromosomal associations between alternatively expressed loci. Nature 435:637-645.
Spilianakis, C. and Papamatheakis, J. and Kretsovali, A. (2000).Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Molecular and Cellular Biology 20:8489-8498.
van Overveld, P. G. M. and Lemmers, Rjfl and Deidda, G. and Sandkuijl, L. and Padberg, G. W. and Frants, R. R. and van der Maarel, S. M. (2000).Interchromosomal repeat array interactions between chromosomes 4 and 10: a model for subtelomeric plasticity. Human Molecular Genetics 9:2879-2884.
Xu, N. and Tsai, C. L. and Lee, J. T. (2006).Transient homologous chromosome pairing marks the onset of X inactivation. Science 311:1149-1152.
Related Readings – Friday Lecture – Jeffrey Friedman Ph.D.
Leptin, Behavior & Metabolism: Balancing the Energy Equation/in vivo/
Friday, March 2, 2007
Caspary Auditorium 3:45 p.m. – 5:15 p.m. Tea at 3:15 p.m. in the Abby Lounge
Recommended Review Article
Spiegelman, B. M. and Flier, J. S. (2001).Obesity and the regulation of energy balance. Cell 104:531-543.
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Cohen, P. and Miyazaki, M. and Socci, N. D. and Hagge-Greenberg, A. and Liedtke, W. and Soukas, A. A. and Sharma, R. and Hudgins, L. C. and Ntambi, J. M. and Friedman, J. M. (2002).Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297:240-243.
Cowley, M. A. and Smart, J. L. and Rubinstein, M. and Cordan, M. G. and Diano, S. and Horvath, T. L. and Cone, R. D. and Low, M. J. (2001).Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484.
Cowley, M. A. and Smith, R. G. and Diano, S. and Tschop, M. and Pronchuk, N. and Grove, K. L. and Strasburger, C. J. and Bidlingmaier, M. and Esterman, M. and Heiman, M. L. and Garcia-Segura, L. M. and Nillni, E. A. and Mendez, P. and Low, M. J. and Sotonyi, P. and Friedman, J. M. and Liu, H. Y. and Pinto, S. and Colmers, W. F. and Cone, R. D. and Horvath, T. L. (2003).The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661.
Ellacott, K. L. J. and Cone, R. D. (2006).The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models. Philosophical Transactions of the Royal Society B-Biological Sciences 361:1265-1274.
Friedman, J. M. and Halaas, J. L. (1998).Leptin and the regulation of body weight in mammals. Nature 395:763-770.
Heisler, L. K. and Jobst, E. E. and Sutton, G. M. and Zhou, L. G. and Borok, E. and Thornton-Jones, Z. and Liu, H. Y. and Zigman, J. M. and Balthasar, N. and Kishi, T. and Lee, C. E. and Aschkenasi, C. J. and Zhang, C. Y. and Yu, J. and Boss, O. and Mountjoy, K. G. and Clifton, P. G. and Lowell, B. B. and Friedman, J. M. and Horvath, T. and Butler, A. A. and Elmquist, J. K. and Cowley, M. A. (2006).Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 51:239-249.
Pinto, S. and Roseberry, A. G. and Liu, H. Y. and Diano, S. and Shanabrough, M. and Cai, X. L. and Friedman, J. M. and Horvath, T. L. (2004).Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304:110-115.