Recommended Readings: Carolyn Bertozzi, Ph.D., June 3

Friday Lecture Series
Friday, June 3, 2016
3:45 p.m., Caspary Auditorium

Carolyn Bertozzi, Ph.D.,
Anne T. and Robert M. Bass Professor of Chemistry,
Professor of Chemical & Systems Biology and Radiology (By Courtesy),
Stanford University
Investigator, Howard Hughes Medical Institute

Precision Glycocalyx Editing for Cancer Immune Therapy

Recommended Readings:

Agarwal, P., Beahm, B. J., Shieh, P., & Bertozzi, C. R. (2015). Systemic fluorescence imaging of zebrafish glycans with bioorthogonal chemistry. Angewandte Chemie, 127(39), 11666-11672. doi: 10.1002/anie.201504249.

Agarwal, P., & Bertozzi, C. R. (2015). Site-specific antibody–drug conjugates: The nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjugate Chemistry, 26(2), 176-192. doi: 10.1021/bc5004982.

Hudak, J. E., Canham, S. M., & Bertozzi, C. R. (2014). Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nature Chemical Biology, 10(1), 69-75. doi: 10.1038/nchembio.1388.

Woods, E. C., Yee, N. A., Shen, J., & Bertozzi, C. R. (2015). Glycocalyx engineering with a recycling glycopolymer that increases cell survival in vivo. Angewandte Chemie, 127(52), 16008-16014. doi: 10.1002/anie.201508783.

Recommended Readings: Angelika Amon, Ph.D., May 27

Friday Lecture Series
Friday, May 27, 2016
3:45 p.m., Caspary Auditorium

Angelika Amon, Ph.D.
Kathleen and Curtis Marble Professor of Cancer Research,
Koch Institute for Integrative Cancer Research,
Massachusetts Institute of Technology
Investigator, Howard Hughes Medical Institute

The Causes and Consequences of Aneuploidy

Recommended Readings:

Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., … & Amon, A. (2011). Aneuploidy drives genomic instability in yeast. Science, 333(6045), 1026-1030. doi: 10.1126/science.1206412.

Sheltzer, J. M., Torres, E. M., Dunham, M. J., & Amon, A. (2012). Transcriptional consequences of aneuploidy. Proceedings of the National Academy of Sciences, 109(31), 12644-12649. doi: 10.1073/pnas.1209227109.

Tang, Y. C., & Amon, A. (2013). Gene copy-number alterations: a cost-benefit analysis. Cell, 152(3), 394-405. doi: 10.1016/j.cell.2012.11.043.

Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007). Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science, 317(5840), 916-924. doi: 10.1126/science.1142210

Recommended Readings: Joseph Schlessinger, Ph.D., May 13

Friday Lecture Series
Friday, May 13, 2016
3:45 p.m., Caspary Auditorium

Joseph Schlessinger, Ph.D.
William H. Prusoff Professor and Chair,
Department of Pharmacology,
Yale School of Medicine

Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy

Recommended Readings:

Empirical Articles

Bae, J. H., Lew, E. D., Yuzawa, S., Tomé, F., Lax, I., & Schlessinger, J. (2009). The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell, 138(3), 514-524. doi: 10.1016/j.cell.2009.05.028.

Chung, I., Akita, R., Vandlen, R., Toomre, D., Schlessinger, J., & Mellman, I. (2010). Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature, 464(7289), 783-787. doi: 10.1038/nature08827.

Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., & Schlessinger, J. (2007). Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell, 130(2), 323-334.

Review Papers

Lemmon, M. A., & Schlessinger, J. (2010). Cell signaling by receptor tyrosine kinases. Cell, 141(7), 1117-1134. doi: 10.1016/j.cell.2010.06.011.

Schlessinger, J. (2014). Receptor tyrosine kinases: legacy of the first two decades. Cold Spring Harbor Perspectives in Biology, 6(3), a008912. doi: 10.1101/cshperspect.a008912.

Recommended Readings: Tom A. Rapoport, Ph.D., May 6

Friday Lecture Series
Friday, May 6, 2016
3:45 p.m., Caspary Auditorium

Tom A. Rapoport, Ph.D.
Professor, Department of Cell Biology,
Harvard Medical School
Investigator, Howard Hughes Medical Institute

How an Organelle Gets into Shape

Recommended Readings:

Hu, J., Shibata, Y., Voss, C., Shemesh, T., Li, Z., Coughlin, M., … & Prinz, W. A. (2008). Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science, 319(5867), 1247-1250. doi: 10.1126/science.1153634.

Shemesh, T., Klemm, R. W., Romano, F. B., Wang, S., Vaughan, J., Zhuang, X., … & Rapoport, T. A. (2014). A model for the generation and interconversion of ER morphologies. Proceedings of the National Academy of Sciences, 111(49), E5243-E5251. doi: 10.1073/pnas.1419997111.

Shibata, Y., Hu, J., Kozlov, M. M., & Rapoport, T. A. (2009). Mechanisms shaping the membranes of cellular organelles. Annual Review of Cell and Developmental, 25, 329-354. doi: 10.1146/annurev.cellbio.042308.113324.

Shibata, Y., Shemesh, T., Prinz, W. A., Palazzo, A. F., Kozlov, M. M., & Rapoport, T. A. (2010). Mechanisms determining the morphology of the peripheral ER. Cell, 143(5), 774-788. doi: 10.1016/j.cell.2010.11.007.

Shibata, Y., Voeltz, G. K., & Rapoport, T. A. (2006). Rough sheets and smooth tubules. Cell, 126(3), 435-439.

Recommended Readings: Mary Jeanne Kreek, M.D., May 2

Monday Lecture Series
Monday, May 2, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Mary Jeanne Kreek, M.D.
Senior Attending Physician,
The Rockefeller University Hospital
Patrick E. and Beatrice M. Haggerty Professor and Head,
Laboratory of the Biology of Addictive Diseases,
The Rockefeller University

50th Anniversary of First Research Paper on Methadone Maintenance Treatment: Update on Molecular, Neurobiological, Behavioral, and Genetic Research

Recommended Readings:

Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., … & Tischfield, J. A. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction. Proceedings of the National Academy of Sciences, 95(16), 9608-9613.

Butelman, E. R., Yuferov, V., & Kreek, M. J. (2012). κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends in Neurosciences, 35(10), 587-596. doi:10.1016/j.tins.2012.05.005.

Dole, V. P., Nyswander, M. E., & Kreek, M. J. (1966). Narcotic blockade. Archives of Internal Medicine, 118(4), 304-309. doi:10.1001/archinte.1966.00290160004002

Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8(11), 1450-1457. doi:10.1038/nn1583

Reed, B., Butelman, E. R., Yuferov, V., Randesi, M., & Kreek, M. J. (2014). Genetics of opiate addiction. Current Psychiatry Reports, 16(11), 1-12. doi:10.1007/s11920-014-0504-6.

Recommended Readings: Tarun Kapoor, Ph.D., April 18

Monday Lecture Series
Monday, April 18, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Tarun Kapoor, Ph.D.
Pels Family Professor and Head,
Selma and Lawrence Ruben Laboratory of Chemistry and Cell Biology,
The Rockefeller University

New Chemical Probes for Ribosome Biogenesis and Cytoskeleton Organization

Recommended Readings

Kasap, C., Elemento, O., & Kapoor, T. M. (2014). DrugTargetSeqR: a genomics-and CRISPR-Cas9–based method to analyze drug targets. Nature Chemical Biology, 10(8), 626-628. doi: 10.1038/nchembio.1551

See, S. K., Hoogendoorn, S., Chung, A. H., Ye, F., Steinman, J. B., Sakata-Kato, T., … & Chen, J. K. (2015). Cytoplasmic dynein antagonists with improved potency and isoform selectivity. ACS Chemical Biology, 11(1), 53-60. doi:10.1021/acschembio.5b00895

Shimamoto, Y., Forth, S., & Kapoor, T. M. (2015). Measuring pushing and braking forces generated by ensembles of kinesin-5 crosslinking two microtubules. Developmental Cell, 34(6), 669-681. doi:10.1016/j.devcel.2015.08.017

Recommended Readings: Rod MacKinnon, M.D., Ph.D., April 11

Monday Lecture Series
Monday, April 11, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Rod MacKinnon, M.D., Ph.D.
John D. Rockefeller Jr. Professor and Head,
Laboratory of Molecular Neurobiology and Biophysics,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Some Experiments That Excite Me Right Now

Recommended Readings

Brohawn, S. G., Campbell, E. B., & MacKinnon, R. (2014). Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516(7529), 126-130. doi:10.1038/nature14013

Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., … & MacKinnon, R. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280(5360), 69-77. doi:10.1126/science.280.5360.69

Hite, R. K., Yuan, P., Li, Z., Hsuing, Y., Walz, T., & MacKinnon, R. (2015). Cryo-electron microscopy structure of the Slo2. 2 Na+-activated K+ channel. Nature, 527(7577), 198-203.  doi:10.1038/nature14958

MacKinnon, R. (2004). Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angewandte Chemie, 43(33), 4265-4277.

Recommended Readings: Paul Cohen, M.D., Ph.D., April 25

Monday Lecture Series
Monday, April 25, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Paul Cohen, M.D., Ph.D.
Albert Resnick, M.D., Assistant Professor and Head,
Laboratory of Molecular Metabolism,
The Rockefeller University

Molecular Regulation of Fat Cell Phenotype

Recommended Readings

Chi, J., & Cohen, P. (2016). The multifaceted roles of PRDM16: Adipose biology and beyond. Trends in Endocrinology & Metabolism, 27(1), 11-23. doi:10.1016/j.tem.2015.11.005

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D. P., Svensson, K. J., … & Wu, J. (2014). Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell, 156(1), 304-316. doi:10.1016/j.cell.2013.12.021

Cohen, P., & Spiegelman, B. M. (2015). Brown and beige fat: molecular parts of a thermogenic machine. Diabetes, 64(7), 2346-2351. doi: 10.2337/db15-0318

Kir, S., White, J. P., Kleiner, S., Kazak, L., Cohen, P., Baracos, V. E., & Spiegelman, B. M. (2014). Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature, 513(7516), 100-104. doi:10.1038/nature13528

Recommended Readings: Jennifer Lippincott-Schwartz, Ph.D., April 22

Friday Lecture Series
Friday, April 22, 2016
3:45 p.m., Caspary Auditorium

Jennifer Lippincott-Schwartz, Ph.D.
Group Leader
Howard Hughes Medical Institute – Janelia Research Campus

Navigating the cellular landscape with new optical probes, imaging strategies and technical innovations

Recommended Readings

Chen, B. C., Legant, W. R., Wang, K., Shao, L., Milkie, D. E., Davidson, M. W., … & Betzig, E. (2014). Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution. Science, 346(6208), 1257998. doi:10.1126/science.1257998.

Ritter, A. T., Asano, Y., Stinchcombe, J. C., Dieckmann, N. M. G., Chen, B. C., Gawden-Bone, C., … & Betzig, E. (2015). Actin depletion initiates events leading to granule secretion at the immunological synapse. Immunity, 42(5), 864-876. doi:10.1016/j.immuni.2015.04.013.

Sengupta, P., Van Engelenburg, S., & Lippincott-Schwartz, J. (2012). Visualizing cell structure and function with point-localization superresolution imaging. Developmental Cell, 23(6), 1092-1102. doi: 10.1016/j.devcel.2012.09.022.

Shcherbakova, D. M., Sengupta, P., Lippincott-Schwartz, J., & Verkhusha, V. V. (2014). Photocontrollable fluorescent proteins for superresolution imaging. Annual Review of Biophysics, 43, 303-329. doi: 10.1146/annurev-biophys-051013-022836.

Recommended Readings: Tony Hunter, Ph.D., April 29

Friday Lecture Series
Friday, April 29, 2016
3:45 p.m., Caspary Auditorium

Tony Hunter, Ph.D.
Director, Molecular and Cell Biology Laboratory,
Renato Dulbecco Chair in Cancer Research,
American Cancer Society Professor,
Salk Institute for Biological Studies

Post-translational regulation of cell signaling

Recommended Readings

Hunter, T. (2014). The genesis of tyrosine phosphorylation. Cold Spring Harbor Perspectives in Biology, 6(5), a020644. doi: 10.1101/cshperspect.a020644

Hunter, T. (2015). Discovering the first tyrosine kinase. Proceedings of the National Academy of Sciences, 112(26), 7877–7882. doi: 10.1073/pnas.1508223112