Recommended Readings: Elly Tanaka, Ph.D. March 17, 2017

Friday Lectures

Friday, March 17, 2017   3:45 p.m.

Caspary Auditorium

Elly Tanaka, Ph.D.

Senior Scientist,

Research Institute of Molecular Pathology, Vienna, Austria

The Control of Growth, Signaling, and Patterning during Vertebrate Limb Regeneration

Recommended Readings:

https://medicalxpress.com/news/2017-03-inflammation-regeneration-friend-foe.html

Tanaka, Elly M. (2016). The Molecular and Cellular Choreography of Appendage on Regeneration. CELL. 165(7): 1598-1608

Tornini, Valerie A.; Puliafito, Alberto; Slota, Leslie A.; et al. (2016). Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. CURRENT BIOLOGY. 26(22): 2981-2991 

Sandoval-Guzman, Tatiana; Wang, Heng; Khattak, Shahryar; et al. (2014). Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species. CELL STEM CELL. 14(2): 174-187

Khattak, Shahryar; Schuez, Maritta; Richter, Tobias; et al. (2013). Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl. STEM CELL REPORTS. 1(1): 90-103

Simon, Andras; Tanaka, Elly M. (2013). Limb regeneration.  WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY. 2(2): 291-300

Recommended Readings: Maria Barna Ph.D. Friday December 9, 2016

Friday Lectures

Friday, December 9, 2016   3:45 p.m.

Caspary Auditorium

Maria Barna, Ph.D.

Assistant Professor,

Departments of Developmental Biology and Genetics at Stanford University

Specialized Ribosomes:

A New Frontier in Gene Regulation, Organismal Biology, & Evolution

Recommended Readings:

Xue, Shifeng; Barna, Maria.   Specialized ribosomes: a new frontier in gene regulation and organismal biology.  NATURE REVIEWS MOLECULAR CELL BIOLOGY    13( 6):355-369     JUN 2012

Amunts, Alexey; Brown, Alan; Bai, Xiao-chen; et al.  Structure of the Yeast Mitochondrial Large Ribosomal Subunit.  SCIENCE   343(6178):1485-1489      MAR 28 2014

Xue, Shifeng; Tian, Siqi; Fujii, Kotaro; et al.  RNA regulons in Hox 5 ‘ UTRs confer ribosome specificity to gene regulation. NATURE   517(7532):33-U55   JAN 1 2015

Wu, XQ; Iyengar, P; RajBhandary, UL.   Ribosome-initiator tRNA complex as an intermediate in translation initiation in Escherichia coli revealed by use of mutant initiator tRNAs and specialized ribosomes. EMBO JOURNAL    15(17):4734-4739  SEP 2 1996

Shi, Zhen; Barna, Maria   Trransiating the Genome in Time and Space: Specialized Ribosomes, RNA. Regulons, and RNA-Binding Proteins. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31   Book Series: Annual Review of Cell and Developmental Biology   V. 31: 31-+    2015

Yadav, Anupama; Radhakrishnan, Aparna; Panda, Anshuman; et al. The Modular Adaptive Ribosome.   PLOS ONE   11(11): Article Number: e0166021    NOV 3 2016

 

Recommended Readings: Tania Baker Ph.D. Friday, November 18, 2016

Friday Lectures

Friday, November 18, 2016   3:45 p.m.

Caspary Auditorium

Tania Baker, Ph.D.

Edwin C. Whitehead Professor of Biology, MIT

Investigator, HHMI

Operations of AAA+ Unfoldase Motors:

Powerful Destroyers and Activators of Protein Function

Selected Publications:

Baker, Tania A.; Sauer, Robert T.  ClpXP, an ATP-powered unfolding and protein-degradation machine.    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH.   1823(Special Issue SI): 15-28     JAN 2012

Stinson, Benjamin M.; Nager, Andrew R.; Glynn, Steven E.; et al.  Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA plus Machine. CELL   153(3):628-639    APR 25 2013

Glynn, Steven E.; Nager, Andrew R.; Baker, Tania A.; et al.   Dynamic and static components power unfolding in topologically closed rings of a AAA plus proteolytic machine.   NATURE STRUCTURAL & MOLECULAR BIOLOGY.  19(6):616-+   JUN 2012

Cordova, Juan Carlos; Olivares, Adrian O.; Shin, Yongdae; et al.    Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine.  CELL    158(3): 647-658     JUL 31 2014

Olivares, Adrian O.; Nager, Andrew R.; Iosefson, Ohad; et al.   Mechanochemical basis of protein degradation by a double-ring AAA plus machine.   NATURE STRUCTURAL & MOLECULAR BIOLOGY    21(10): 871-875    OCT 2014

 

Recommended Readings: Frederick Cross Ph.D. Monday December 5, 2016

Monday Lectures

 December 5, 2016

4:00 p.m.  Carson Family Auditorium  CRC

Frederick Cross  Ph.D.

Professor,  Laboratory of Cell Cycle Genetics

The Rockefeller University

Evolution of Cell Cycle Control:

Branches and a Green Microbe

Recommended Readings:

Tulin, Frej; Cross, Frederick R.  Patching Holes in the Chlamydomonas Genome.  G3-GENES GENOMES GENETICS   6(7): 1899-1910   JUL 1 2016

Onishi, Masayuki; Pringle, John R.; Cross, Frederick R.   Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas.  GENETICS    202(30): 977-+  MAR 2016

Tulin, Frej; Cross, Frederick R.   A Microbial Avenue to Cell Cycle Control in the Plant Superkingdom.   PLANT CELL   26(10): 4019-4038     OCT 2014

Cross, Frederick R.; Umen, James G.  The Chlamydomonas cell cycle   PLANT JOURNAL   82(3): 370-392   MAY 2015

Recommended Readings: Michael O’Donnell Ph.D. Monday December 12, 2016

Monday Lectures

 December 12, 2016

4:00 p.m.  Carson Family Auditorium  CRC

Michael O’Donnell  Ph.D.

HHMI Investigator, and Anthony and Judith Evnin Professor
Laboratory of DNA Replication

The Rockefeller University

The Eukaryotic Replisome

Recommended Readings:

O’Donnell, Mike; Li, Huilin   The Eukaryotic Replisome Goes Under the Microscope.  CURRENT BIOLOGY  26(6): R247-R256      MAR 21 2016

Yuan, Zuanning; Bai, Lin; Sun, Jingchuan; et al.   Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.  NATURE STRUCTURAL & MOLECULAR BIOLOGY   23(3): 217-224     MAR 2016

Sun, Jingchuan; Shi, Yi; Georgescu, Roxana E.; et al.   The architecture of a eukaryotic replisome.   NATURE STRUCTURAL & MOLECULAR BIOLOGY    22(12): 976-982 DEC 2015

Georgescu, Roxana E.; Schauer, Grant D.; Yao, Nina Y.; et al.  Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation.      ELIFE    4: e04988     APR 14 2015

O’Donnell, Michael; Langston, Lance; Stillman, Bruce  Principles and Concepts of DNA Replication in Bacteria, Archaea, and Eukarya .   COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY    5(7): a010108

Recommended Readings: Eric N. Olson Ph.D. Friday December 2, 2016

Friday Lecture Series

 December 2, 2016

3:45 p.m. (refreshments 3:15)  Caspary Auditorium

Eric N. Olson, Ph.D.

Founding Chair, Department of Molecular Biology.

University of Texas Southwestern Medical Center

The Molecules and Mechanisms of Muscle Development,

Disease and Regeneration

Recommended Readings:

Shadrin, I. Y.; Khodabukus, A.; Bursac, N.   Striated muscle function, regeneration, and repair.  CELLULAR AND MOLECULAR LIFE SCIENCES.    73(22):4175-4202   NOV 2016

McCullagh, Karl J. A.; Perlingeiro, Rita C. R.  Coaxing stem cells for skeletal muscle repair.  ADVANCED DRUG DELIVERY REVIEWS    84: 198-207   APR 2015  REQUEST FROM MARKUS LIBRARY

Juhas, Mark; Bursac, Nenad   Engineering skeletal muscle repair.  CURRENT OPINION IN BIOTECHNOLOGY    24(5): 880-886    OCT 2013

Garbern, Jessica C.; Lee, Richard T.    Cardiac Stem Cell Therapy and the Promise of Heart Regeneration.  CELL STEM CELL  12(6): 689-698   JUN 6 2013 

Xin, Mei; Olson, Eric N.; Bassel-Duby, Rhonda   Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.  NATURE REVIEWS MOLECULAR CELL BIOLOGY     14(8): 529-541    AUG 2013

Nicklas, Sarah; Otto, Anthony; Wu, Xiaoli; et al.   TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration.  PLOS ONE   7 (1): e30445    JAN 27 2012  

Recommended Readings: Jennifer A. Zallen Ph.D. Friday November 11, 2016

Friday Lectures

Frfday, November 11, 2016   3:45 p.m.

Caspary Auditorium

Jennifer A. Zallen, Ph.D.

HHMI Investigator / Member, Sloan Kettering Institute

Signals and Forces that Control Multicellular

Organization in the Embryo

Recommended Readings:

Mao, Qiyan; Lecuit, Thomas    Mechanochemical Interplay Drives Polarization in Cellular and Developmental Systems.  Book Series: Current Topics in Developmental Biology   Volume:116   Pages: 633-+    2016   Edited by: Wassarman, PM

Gouti, Mina; Metzis, Vicki; Briscoe, James.  The route to spinal cord cell types: a tale of signals and switches.TRENDS IN GENETICS   31(6): 282-289   Published: JUN 2015

Uriu, Koichiro; Morelli, Luis G.; Oates, Andrew C.  Interplay between intercellular signaling and cell movement in development.  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY    35: 66-72      NOV 2014

Neijts, Roel; Simmini, Salvatore; Giuliani, Fabrizio; et al   Region-Specific Regulation of Posterior Axial Elongation During Vertebrate Embryogenesis.  DEVELOPMENTAL DYNAMICS   243(1. Special Issue: SI): 88-98    JAN 2014

 Zallen, Jennifer A.; Blankenship, J. Todd   Multicellular dynamics during epithelial elongation.  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY.   19(3): 263-270 : JUN 2008

Recommended Readings: Shixin Liu Ph.D. Monday November 14 2016

Monday Lectures

Monday November 14, 2016   3:45 p.m.

Caspary Auditorium

Shixin Liu   Ph.D.

Assistant Professor, The Rockefeller University

Laboratory of Nanoscale Biophysics and Biochemistry

Watching Biological Machines in Action

Recommended Readings:

 Liu, Shixin; Chistol, Gheorghe; Hetherington, Craig L.; et al.  A Viral Packaging Motor Varies Its DNA Rotation and Step Size to Preserve Subunit Coordination as the Capsid Fills.  CELL    157 (3):702-713     APR 24 2014

Chemla, Yann R.  High-Resolution, Hybrid Optical Trapping Methods, and Their Application to Nucleic Acid Processing Proteins.  BIOPOLYMERS   105(10): 704-714    OCT 2016

Ha, Taekjip.  Single-molecule methods leap aheadNATURE METHODS    11(10)1015-1018    OCT 2014

Guo, Peixuan; Grainge, Ian; Zhao, Zhengyi; et al.  Two classes of nucleic acid translocation motors: rotation and revolution without rotation. CELL AND BIOSCIENCE  4:54     SEP 16 2014

Casjens, Sherwood R.  The DNA-packaging nanomotor of tailed bacteriophages.  NATURE REVIEWS MICROBIOLOGY   9(9):647-657   SEP 2011

Chemla, YR; Aathavan, K; Michaelis, J; et al.  Mechanism of force generation of a viral DNA packaging motor. CELL   122(5 ): 683-692   : SEP 9 2005 

Recommended Readings: Elaine Fuchs PhD October 24, 2016

Monday Lecture Series

Monday October 24, 2016   3:45 p.m.

Caspary Auditorium

Elaine Fuchs, Ph.D.

Rebecca Lancefield Professor

Laboratory of Mammalian Cell Biology and Development

Skin Stem Cells in Silence, Action and Cancer

Recommended Readings:

Quist, S. R.; Eckardt, M.; Kriesche, A.; et al.  Expression of epidermal stem cell markers in skin and adnexal malignancies. BRITISH JOURNAL OF DERMATOLOGY   175(3):520-530     SEP 2016

 Holland, Jane D.; Klaus, Alexandra; Garratt, Alistair N.; et al.  Wnt signaling in stem and cancer stem cells.  CURRENT OPINION IN CELL BIOLOGY    25(2):254-264  APR 2013

Arwert, Esther N.; Hoste, Esther; Watt, Fiona M.    Epithelial stem cells, wound healing and cancer.  NATURE REVIEWS CANCER   12(3):170-180   MAR 2012

Blanpain, Cedric; Fuchs, Elaine  STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration.  SCIENCE   344(6189):1243-+  ( Article Number: 1242281)  JUN 13 2014

Hsu, Ya-Chieh; Li, Lishi; Fuchs, Elaine  Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration. CELL   157(4):935-949     MAY 8 2014

Fuchs, Elaine; Chen, Ting  A matter of life and death: self-renewal in stem cells.  EMBO REPORTS   14 (1): 39-48   JAN 2013 

Oshimori, Naoki; Fuchs, Elaine   The Harmonies Played by TGF-beta in Stem Cell Biology.    CELL STEM CELL   11(6):751-764    DEC 7 2012

Recommended Readings: Sean Brady, Ph.D., May 16

Monday Lecture Series
Monday, May 16, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Sean Brady, Ph.D.
Tri-Institutional Associate Professor,
Evnin Associate Professor and Head,
Laboratory of Genetically Encoded Small Molecules,
The Rockefeller University
Early Career Scientist, Howard Hughes Medical Institute

Bioactive Metabolites from the Human Microbiome: Natural Cures or Snake Oil

Recommended Readings:

Cohen, L. J., Kang, H. S., Chu, J., Huang, Y. H., Gordon, E. A., Reddy, B. V. B., … & Brady, S. F. (2015). Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proceedings of the National Academy of Sciences, 112(35), E4825-E4834. doi: 10.1073/pnas.1508737112.

Charlop-Powers, Z., Milshteyn, A., & Brady, S. F. (2014). Metagenomic small molecule discovery methods. Current Opinion in Microbiology, 19, 70-75. doi: 10.1016/j.mib.2014.05.021.