Recommended Readings: Edward H. Egelman, Ph.D. Friday January 19th, 2018

Friday Lectures

Friday, January 19, 2018  3:45 p.m.

Caspary Auditorium

Edward Egelman, Ph.D.

Harrison Distinguished Professor

Biochemistry and Molecular Genetics

University of Virginia Medical School

Cryo-EM of Protein and Nucleoprotein Polymers at Near-Atomic Resolution

Recommended Readings:

Science News

Kenny Walter. Virus Holds Key to Durable Material. (2017, Jul 20). Virus Holds Key to Durable Material. R&D Magazine

Empirical Articles

Egelman, Edward H. (2017). Cryo-EM of bacterial pili and archaeal flagellar filaments. CURRENT OPINION IN STRUCTURAL BIOLOGY. 46: 31-37

Wang, Fengbin; Burrage, Andrew M.; Postel, Sandra; et al. (2017). A structural model of flagellar filament switching across multiple bacterial species. NATURE COMMUNICATIONS. 8: 960

Wang, Fengbin; Coureuil, Mathieu; Osinski, Tomasz; et al. (2017). Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution. STRUCTURE. 25 (9): 1423-+

Kasson, Peter; DiMaio, Frank; Yu, Xiong; et al. (2017). Model for a novel membrane envelope in a filamentous hyperthermophilic virus. ELIFE. 6  

Kolappan, Subramania; Coureuil, Mathieu; Yu, Xiong; et al. (2016). Structure of the Neisseria meningitidis Type IV pilus. NATURE COMMUNICATIONS. 7: 13015

Braun, Tatjana; Vos, Matthijn R.; Kalisman, Nir; et al. (2016). Archaeal flagellin combines a bacterial type IV pilin domain with an Ig-like domain. PNAS. 113 (37): 10352-10357

Egelman, Edward H. (2016). The Current Revolution in Cryo-EM. BIOPHYSICAL JOURNAL. 110 (5): 1008-1012

Wang, Ray Yu-Ruei; Kudryashev, Mikhail; Li, Xueming; et al. (2015). De novo protein structure determination from near-atomic-resolution cryo-EM maps. NATURE METHODS. 12 (4): 335-U84

DiMaio, Frank; Yu, Xiong; Rensen, Elena; et al. (2015). A virus that infects a hyperthermophile encapsidates A-form DNA. SCIENCE. 348 (6237): 914-917

Review Papers

Egelman, Edward H. (2015). Three-dimensional reconstruction of helical polymers. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 581: 54-58

Recommended Readings: Ali H. Brivanlou, Ph.D. Monday November 20th, 2017

Monday Lectures

Monday, November 20, 2017  3:45 p.m.

Carson Family Auditorium

Ali H. Brivanlou, Ph.D.

Robert and Harriet Heilbrunnand Professor and Head

Laboratory of Stem Cell Biology and Molecular Embryology

The Rockefeller University


Self-organization of Spatial Patterns in Artificial Human Embryos and Organoids

Recommended Readings:


Patrick Monahan.

Empirical Articles

Deglincerti, Alessia; Croft, Gist F.; Pietila, Lauren N.; et al. (2016). Self-organization of the in vitro attached human embryo. NATURE.  533 (7602): 251-+

Etoc, Fred; Metzger, Jakob; Ruzo, Albert; et al. (2016). A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization. DEVELOPMENTAL CELL. 39 (3): 302-315  

Haremaki, Tomomi; Deglincerti, Alessia; Brivanlou, Ali H. (2015). Huntingtin is required for ciliogenesis and neurogenesis during early Xenopus development. DEVELOPMENTAL BIOLOGY. 408 (2): 305-315

Warmflash, Aryeh; Sorre, Benoit; Etoc, Fred; et al. (2014). A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. NATURE METHODS. 11 (8): 847-854

Bedzhov, Ivan; Leung, Chuen Yan; Bialecka, Monika; et al. (2014). In vitro culture of mouse blastocysts beyond the implantation stages. NATURE PROTOCOLS.  9 (12): 2732-2739

Review Paper

Simunovic, Mijo; Brivanlou, Ali H. (2017). Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis.  DEVELOPMENT. 144 (6): 976-985

Clevers, Hans (2016). Modeling Development and Disease with Organoids. CELL. 165 (7): 1586-1597


Recommended Readings: Nancy A. Moran, Ph.D., Friday September 22th, 2017

Friday Lectures

Friday, September 22, 2017  3:45 p.m.

Caspary Auditorium

Nancy A. Moran, Ph.D.

Leslie Surginer Endowed Professor

Department of Integrative Biology

University of Texas

The evolution and function of gut communities in social bees

Recommended Readings:

Ashley P. Taylor. March 29, 2017. In Certain Social Bees, Gut Microbiomes Follow Phylogeny. TheScientist

Kwong, Waldan K.; Moran, Nancy A. (2017). Gut microbial communities of social bees. NATURE REVIEWS MICROBIOLOGY. 14 (6): 374-384

Kwong, Waldan K; Medina, Luis A; Koch, Hauke; et al. (2017). Dynamic microbiome evolution in social bees. SCIENCE ADVANCES. 3 (3): e1600513

Powell, Elijah; Ratnayeke, Nalin; Moran, Nancy A. (2016). Strain diversity and host specificity in a specialized gut symbiont of honeybees and bumblebees. MOLECULAR ECOLOGY. 25 (18): 4461-4471

Engel, Philipp; Moran, Nancy A. (2013). The gut microbiota of insects – diversity in structure and function. FEMS MICROBIOLOGY REVIEW. 37 (5): 699-735

Schloissnig, Siegfried; Arumugam, Manimozhiyan; Sunagawa, Shinichi; et al. (2013). Genomic variation landscape of the human gut microbiome. NATURE. 493 (7430): 45-50

Tian, Baoyu; Fadhil, Nibal H.; Powell, J. Elijah; et al. (2012). Long-Term Exposure to Antibiotics Has Caused Accumulation of Resistance Determinants in the Gut Microbiota of Honeybees. MBIO. 3 (6): e00377-12


Recommended Readings: Daniel Kronauer, Ph.D., Friday September 15th, 2017

Friday Lectures

Friday, September 15, 2017  3:45 p.m.

Caspary Auditorium

Daniel Kronauer, Ph.D.

Stanley S. and Sydney R. Shuman Assistant Professor and Head

Laboratory of Social Evolution and Behavior

The Rockefeller University

Communication and Social Behavior in Ants

Recommended Readings:

News provided by NYU Langone Health (2017). Mutant Ants provide insights into social interaction.

Trible, Waring; Olivos-Cisneros, Leonora; McKenzie, Sean K.; et al. (2017). orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants. CELL. 170 (4): 727-+  

McKenzie, Sean K.; Fetter-Pruneda, Ingrid; Ruta, Vanessa; et al. (2016). Transcriptomics and neuroanatomy of the clonal raider ant implicate an expanded clade of odorant receptors in chemical communication. PNAS. 113 (49): 14091-14096

Leonhardt, Sara Diana; Menzel, Florian; Nehring, Volker; et al. (2016). Ecology and Evolution of Communication in Social Insects. CELL. 164 (6): 1277-1287

Oxley, Peter R.; Ji, Lu; Fetter-Pruneda, Ingrid; et al. (2014). The Genome of the Clonal Raider Ant Cerapachys biroi. CURRENT BIOLOGY. 24 (4): 451-458  

Sumner, Seirian (2014). The importance of genomic novelty in social evolution. MOLECULAR ECOLOGY. 23 (1): 26-28


Recommended Readings: Jon Clardy, Ph.D. March 24, 2017

Friday Lectures

Friday, March 24, 2017   3:45 p.m.

Caspary Auditorium

Jon Clardy, Ph.D.

Hsien Wu and Daisy Yen Wu Professor,

Department of Biological Chemistry and Molecular Pharmacology

The Rockefeller University

Small Molecule Modulators of Multilateral Symbioses

Recommended Readings:

Pupo, Monica T.; Currie, Cameron R.; Clardy, Jon (2017). Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY. 28 (3): 393-401

Ruzzini, Antonio C.; Clardy, Jon (2016). Gene Flow and Molecular Innovation in Bacteria. CURRENT BIOLOGY. 26(18)R859-R864

Cantley, Alexandra M.; Clardy, Jon (2015). Animals in a bacterial world: opportunities for chemical ecology.  NATURAL PRODUCT REPORTS. 32(7): 888-892

Sit, Clarissa S.; Ruzzini, Antonio C.; Van Arnam, Ethan B.; et al. (2015). Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112(43)13150-13154

Ramadhar, Timothy R.; Beemelmanns, Christine; Currie, Cameron R.; et al. (2014). Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discover. JOURNAL OF ANTIBIOTICS. 67(1): 53-58

Crawford, Jason M.; Clardy, Jon (2011). Bacterial symbionts and natural products. CHEMICAL COMMUNICATIONS. 47(27): 7559-7566

Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R.; et al. (2009). Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.  NATURE CHEMICAL BIOLOGY. 5(6) 391-393




Recommended Readings: Elly Tanaka, Ph.D. March 17, 2017

Friday Lectures

Friday, March 17, 2017   3:45 p.m.

Caspary Auditorium

Elly Tanaka, Ph.D.

Senior Scientist,

Research Institute of Molecular Pathology, Vienna, Austria

The Control of Growth, Signaling, and Patterning during Vertebrate Limb Regeneration

Recommended Readings:

Tanaka, Elly M. (2016). The Molecular and Cellular Choreography of Appendage on Regeneration. CELL. 165(7): 1598-1608

Tornini, Valerie A.; Puliafito, Alberto; Slota, Leslie A.; et al. (2016). Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration. CURRENT BIOLOGY. 26(22): 2981-2991 

Sandoval-Guzman, Tatiana; Wang, Heng; Khattak, Shahryar; et al. (2014). Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species. CELL STEM CELL. 14(2): 174-187

Khattak, Shahryar; Schuez, Maritta; Richter, Tobias; et al. (2013). Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl. STEM CELL REPORTS. 1(1): 90-103

Simon, Andras; Tanaka, Elly M. (2013). Limb regeneration.  WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY. 2(2): 291-300

Recommended Readings: Frederick Cross Ph.D. Monday December 5, 2016

Monday Lectures

 December 5, 2016

4:00 p.m.  Carson Family Auditorium  CRC

Frederick Cross  Ph.D.

Professor,  Laboratory of Cell Cycle Genetics

The Rockefeller University

Evolution of Cell Cycle Control:

Branches and a Green Microbe

Recommended Readings:

Tulin, Frej; Cross, Frederick R.  Patching Holes in the Chlamydomonas Genome.  G3-GENES GENOMES GENETICS   6(7): 1899-1910   JUL 1 2016

Onishi, Masayuki; Pringle, John R.; Cross, Frederick R.   Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas.  GENETICS    202(30): 977-+  MAR 2016

Tulin, Frej; Cross, Frederick R.   A Microbial Avenue to Cell Cycle Control in the Plant Superkingdom.   PLANT CELL   26(10): 4019-4038     OCT 2014

Cross, Frederick R.; Umen, James G.  The Chlamydomonas cell cycle   PLANT JOURNAL   82(3): 370-392   MAY 2015

Recommended Readings: Nicole King Ph.D. October 7 2016

Friday Lecture Series

Friday October 7, 2016   3:45 p.m.

The Fairfield Osborn Memorial Lecture

Caspary Auditorium

Nicole King

Professor, and HHMI Investigator

Dept.of Molecular and Cell Biology, Division of Genetics, Genomics and Development

University of California Berkeley

Bacteria as Master Regulators and Aphrodisiacs

Recommended Readings:

Anderson, Douglas P.; Whitney, Dustin S.; Hanson-Smith, Victor; et al.  Evolution of an ancient protein function involved in organized multicellularity in animals. ELIFE                   5: e10147    JAN 7 2016

Alegado, Rosanna A.; King, Nicole  Bacterial Influences on Animal OriginsCOLD SPRING HARBOR PERSPECTIVES IN BIOLOGY    6(11): a016162  NOV 2014

King, Nicole.  Evolutionary Transitions to Multicellular Life Principles and Mechanisms Forrward.  EVOLUTIONARY TRANSITIONS TO MULTICELLULAR LIFE: PRINCIPLES AND MECHANISMS   Book Series:Advances in Marine Genomics   Volume: 2   Pages: V-VI    2015

King, Nicole; Mueller, Susann.  Environmental microbiology: Revisiting the physiology of microorganisms on the single cell scale. CURRENT OPINION IN MICROBIOLOGY     Volume: 25   Pages: V-VI   Published: JUN 2015

Recommended Readings: Uri Alon Ph.D. October 28 2016

Friday Lecture Series

Friday  October 28  2016    3:45  p.m.

Caspary Auditorium

Uri Alon

Professor, Department of Molecular Cell Biology

Weizmann Institute of Science

Evolutionary Trade Offs and the Geometry of Phenotype Space

Recommended Readings:

Keren, Leeat; Hausser, Jean; Lotan-Pompan, Maya; et al. Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness. CELL    166(5):1282-+  AUG 25 2016

Korem, Yael; Szekely, Pablo; Hart, Yuval; et al. Geometry of the Gene Expression Space of Individual Cells. PLOS COMPUTATIONAL BIOLOGY    11(7):e1004224   JUL 2015

Tendler, Avichai; Mayo, Avraham; Alon, Uri  Evolutionary tradeoffs, Pareto optimality and the morphology of ammonite shells. BMC SYSTEMS BIOLOGY  V 9: article number: 12   MAR 7 2015

Szekely, Pablo; Sheftel, Hila; Mayo, Avi; et al. Evolutionary Tradeoffs between Economy and Effectiveness in Biological Homeostasis Systems.  PLOS COMPUTATIONAL BIOLOGY.   9(8): e1003163    AUG 2013

Sheftel, Hila; Shoval, Oren; Mayo, Avi; et al. The geometry of the Pareto front in biological phenotype space. ECOLOGY AND EVOLUTION.   3(6):1471-1483    JUN 2013

Recommended Readings: Michael Levine Ph.D. Sept 30, 2016

Friday Lecture Series

Norton Zinder Lecture

Michael Levine, Ph.D.

Director, Lewis-Sigler Institute for Integrative Genomics, Princeton Univ.

Anthony B. Evnin Professor, Dept Molecular Biology, Princeton Univ.

Visualization and evolution of transcriptional enhancers

Recommended Readings:

Bothma, J.P., Garcia, H.G., Ng, S., Perry, M.W., Gregor, T., and Levine, M. (2015). Enhancer additivity and nonadditivity are determined by enhancer strength in the Drosophila embryo. eLife 4, 07956.

Farley, E.K., Olson, K.M., Zhang, W., Brandt, A.J., Rokhsar, D.S., and Levine, M. (2015). Suboptimization of developmental enhancers. Science 350, 325-328.

Fukaya, T., Lim, B., and Levine, M. 2016. Enhancer control of transcriptional bursting. Cell 166, 358-368.

Bothma, J., Garcia, H., Gavin, S., Esposito, E., Gregor, T., and Levine, M. (2014). Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophila embryos. PNAS 111, 10598-10603.

Evans, Nicole C.; Swanson, Christina I.; Barolo, Scott.  Sparkling Insights into Enhancer Structure, Function, and Evolution.  TRANSCRIPTIONAL SWITCHES DURING DEVELOPMENT   Book Series: Current Topics in Developmental Biology .  98: 97-120   2012

Gordon, Kacy L.; Ruvinsky, Ilya.  Tempo and Mode in Evolution of Transcriptional Regulation.  PLOS GENETICS.   8(1): e1002432    2012