Recommended Readings: Eric N. Olson Ph.D. Friday December 2, 2016

Friday Lecture Series

 December 2, 2016

3:45 p.m. (refreshments 3:15)  Caspary Auditorium

Eric N. Olson, Ph.D.

Founding Chair, Department of Molecular Biology.

University of Texas Southwestern Medical Center

The Molecules and Mechanisms of Muscle Development,

Disease and Regeneration

Recommended Readings:

Shadrin, I. Y.; Khodabukus, A.; Bursac, N.   Striated muscle function, regeneration, and repair.  CELLULAR AND MOLECULAR LIFE SCIENCES.    73(22):4175-4202   NOV 2016

McCullagh, Karl J. A.; Perlingeiro, Rita C. R.  Coaxing stem cells for skeletal muscle repair.  ADVANCED DRUG DELIVERY REVIEWS    84: 198-207   APR 2015  REQUEST FROM MARKUS LIBRARY

Juhas, Mark; Bursac, Nenad   Engineering skeletal muscle repair.  CURRENT OPINION IN BIOTECHNOLOGY    24(5): 880-886    OCT 2013

Garbern, Jessica C.; Lee, Richard T.    Cardiac Stem Cell Therapy and the Promise of Heart Regeneration.  CELL STEM CELL  12(6): 689-698   JUN 6 2013 

Xin, Mei; Olson, Eric N.; Bassel-Duby, Rhonda   Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.  NATURE REVIEWS MOLECULAR CELL BIOLOGY     14(8): 529-541    AUG 2013

Nicklas, Sarah; Otto, Anthony; Wu, Xiaoli; et al.   TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration.  PLOS ONE   7 (1): e30445    JAN 27 2012  

Recommended Readings: Elaine Fuchs PhD October 24, 2016

Monday Lecture Series

Monday October 24, 2016   3:45 p.m.

Caspary Auditorium

Elaine Fuchs, Ph.D.

Rebecca Lancefield Professor

Laboratory of Mammalian Cell Biology and Development

Skin Stem Cells in Silence, Action and Cancer

Recommended Readings:

Quist, S. R.; Eckardt, M.; Kriesche, A.; et al.  Expression of epidermal stem cell markers in skin and adnexal malignancies. BRITISH JOURNAL OF DERMATOLOGY   175(3):520-530     SEP 2016

 Holland, Jane D.; Klaus, Alexandra; Garratt, Alistair N.; et al.  Wnt signaling in stem and cancer stem cells.  CURRENT OPINION IN CELL BIOLOGY    25(2):254-264  APR 2013

Arwert, Esther N.; Hoste, Esther; Watt, Fiona M.    Epithelial stem cells, wound healing and cancer.  NATURE REVIEWS CANCER   12(3):170-180   MAR 2012

Blanpain, Cedric; Fuchs, Elaine  STEM CELL PLASTICITY Plasticity of epithelial stem cells in tissue regeneration.  SCIENCE   344(6189):1243-+  ( Article Number: 1242281)  JUN 13 2014

Hsu, Ya-Chieh; Li, Lishi; Fuchs, Elaine  Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration. CELL   157(4):935-949     MAY 8 2014

Fuchs, Elaine; Chen, Ting  A matter of life and death: self-renewal in stem cells.  EMBO REPORTS   14 (1): 39-48   JAN 2013 

Oshimori, Naoki; Fuchs, Elaine   The Harmonies Played by TGF-beta in Stem Cell Biology.    CELL STEM CELL   11(6):751-764    DEC 7 2012

Recommended Readings: Irving Weissman, M.D.

Friday Lecture Series

The Philip Levine Memorial Lecture

Normal and Neoplastic Stem Cells

Irving Weissman, M.D., director,

Institute of Stem Cell Biology and Regenerative Medicine;

V&D Ludwig Professor of Clinical Cancer Research; and professor, departments of

developmental biology, pathology and neurosurgery and biology,

Stanford University School of Medicine

November 1, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Chao, M. P., Majeti, R., & Weissman, I. L. (2012). Programmed cell removal: A new obstacle in the road to developing cancer. Nature Reviews Cancer, 12(1), 58-67

Jan, M., Snyder, T. M., Corces-Zimmerman, M. R., Vyas, P., Weissman, I. L., Quake, S. R., & Majeti, R. (2012). Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Science Translational Medicine, 4(149)

Lu, R., Neff, N. F., Quake, S. R., & Weissman, I. L. (2011). Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nature Biotechnology, 29(10), 928-934

Pang, W. W., Pluvinage, J. V., Price, E. A., Sridhar, K., Arber, D. A., Greenberg, P. L., . . . Weissman, I. L. (2013). Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proceedings of the National Academy of Sciences of the United States of America, 110(8), 3011-3016

Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., . . . Weissman, I. L. (2011). Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proceedings of the National Academy of Sciences of the United States of America, 108(50), 20012-20017

Uchida, N., Chen, K., Dohse, M., Hansen, K. D., Dean, J., Buser, J. R., . . . Back, S. A. (2012). Human neural stem cells induce functional myelination in mice with severe dysmyelination. Science Translational Medicine, 4(155)

Weissman, I. (2012). Stem cell therapies could change medicine… if they get the chance. Cell Stem Cell, 10(6), 663-665

 

Recommended Readings: George Q. Daley, M.D., Ph.D.

Friday Lecture Series

Maclyn McCarty Memorial Lecture

Reprogramming Cell Identity

George Q. Daley, M.D., Ph.D., Samuel E. Lux, IV Professor of Hematology and

director,Stem Cell Transplantation Program, Boston Children’s Hospital;

investigator, Howard Hughes Medical Institute

October 18, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Cherry, A. B. C., & Daley, G. Q. (2012). Reprogramming cellular identity for regenerative medicine. Cell, 148(6), 1110-1122

Morris, S. A., & Daley, G. Q. (2013). A blueprint for engineering cell fate: Current technologies to reprogram cell identity. Cell Research, 23(1), 33-48

Müller, L. U. W., Milsom, M. D., Harris, C. E., Vyas, R., Brumme, K. M., Parmar, K., . . . Williams, D. A. (2012). Overcoming reprogramming resistance of fanconi anemia cells. Blood, 119(23), 5449-5457

Onder, T. T., Kara, N., Cherry, A., Sinha, A. U., Zhu, N., Bernt, K. M., . . . Daley, G. Q. (2012). Chromatin-modifying enzymes as modulators of reprogramming. Nature, 483(7391), 598-602

Robinton, D. A., & Daley, G. Q. (2012). The promise of induced pluripotent stem cells in research and therapy. Nature, 481(7381), 295-305

Zhang, J., Nuebel, E., Daley, G. Q., Koehler, C. M., & Teitell, M. A. (2012). Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell, 11(5), 589-595

 

Recommended Readings: Leonard Zon, M.D.

SPECIAL SEMINAR
Monday, November 4, 2013
4:00 p.m., Carson Family Auditorium

Leonard Zon, M.D.
Director of the Stem Cell Program at Children’s Hospital Boston
Grousbeck Professor of Pediatric Medicine, Harvard Medical School
Investigator, Howard Hughes Medical Institute

Pathways that Stimulate Stem Cell Development and Self-Renewal

Recommended Readings:

Review Papers

De Jong, J. L. O., & Zon, L. I. (2005). Use of the zebrafish system to study primitive and definitive hematopoiesis. Annual Review of Genetics, 39, 481–501. doi:10.1146/annurev.genet.39.073003.095931

Orkin, S. H., & Zon, L. I. (2008). Hematopoiesis: an evolving paradigm for stem cell biologyCell132(4), 631–644. doi:10.1016/j.cell.2008.01.025

White, R., Rose, K., & Zon, L. (2013). Zebrafish cancer: the state of the art and the path forward. Nature Reviews Cancer, 13(9), 624–636. doi:10.1038/nrc3589

Zon, L. I. (2008). Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature, 453(7193), 306–313. doi:10.1038/nature07038

Empirical Articles

Goessling, W., North, T. E., Loewer, S., Lord, A. M., Lee, S., Stoick-Cooper, C. L., … Zon, L. I. (2009). Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell, 136(6), 1136–1147. doi:10.1016/j.cell.2009.01.015

Lengerke, C., Schmitt, S., Bowman, T. V, Jang, I. H., Maouche-Chretien, L., McKinney-Freeman, S., … Daley, G. Q. (2008). BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell, 2(1), 72–82. doi:10.1016/j.stem.2007.10.022

North, T. E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A. M., … Zon, L. I. (2009). Hematopoietic stem cell development is dependent on blood flow. Cell, 137(4), 736–748. doi:10.1016/j.cell.2009.04.023

North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., … Zon, L. I. (2007). Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature, 447(7147), 1007–1011. doi:10.1038/nature05883

New Blood-vessel-generating Stem Cell with Therapeutic Potential

Researchers at the University of Helsinki, Finland, believe they have discovered stem cells that play a decisive role in new blood vessel growth. If researchers learn to isolate and efficiently produce these stem cells found in blood vessel walls, the cells offer new opportunities in the treatment of cardiovascular diseases, cancer and many other diseases. The study is published in the PLOS Biology journal on 16 October 2012.

Recommended Readings: Elaine Fuchs, Ph.D.

Friday Lecture Series

Skin Stem Cells: In Morphogenesis, Wound Repair and Cancer

Elaine Fuchs, Ph.D., Rebecca C. Lancefield Professor,

The Rockefeller University

March 2, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

 

Recommended Readings:

Blanpain, C., and E. Fuchs. 2009. Epidermal homeostasis: A balancing act of stem cells in the skin. Nature Reviews Molecular Cell Biology 10, (3): 207-217

Ezhkova, E., W. -H Lien, N. Stokes, H. A. Pasolli, J. M. Silva, and E. Fuchs. 2011. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes and Development 25, (5): 485-498

Fuchs, E. 2007. Scratching the surface of skin development. Nature 445, (7130): 834-842

Guasch, G., M. Schober, H. A. Pasolli, E. B. Conn, L. Polak, and E. Fuchs. 2007. Loss of TGFβ signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 12, (4): 313-327

Kobielak, A., and E. Fuchs. 2006. Links between α-catenin, NF-κB, and squamous cell carcinoma in skin. Proceedings of the National Academy of Sciences of the United States of America 103, (7): 2322-2327

Williams, S. E., S. Beronja, H. A. Pasolli, and E. Fuchs. 2011. Asymmetric cell divisions promote notch-dependent epidermal differentiation. Nature 470, (7334): 353-358

Yi, R., and E. Fuchs. 2010. MicroRNA-mediated control in the skin. Cell death and differentiation 17, (2): 229-235

Recommended Readings: Mitchell Guttman, Monday, February 27, 2012

Monday lecture Series

Functional Integration of Large ncRNAs in the Molecular

Circuitry Controlling Cell State

Mitchell Guttman

Graduate Fellow

Broad Institute of MIT and Harvard

   Massachusetts Institute of Technology

Monday, February 27, 2012

4 p.m, Caspary Auditorium.   Refreshments 3:45 p.m.

Recommended Readings:

Yang, LG; Lin CR; Rosebfeld MG. 2011.  A lincRNA switch for embryonic stem cell fate.  Cell Research  21(12):1646-1648.  DOI:10.1038/cr.2011.166

Guttman M; Donachey J; Carey BW; et al. 2011.  lincRNAs act in the circuitry controlling pluripotency and differentiation.  NATURE.  477(7364):295-U60.   DOI:10.1038/nature10398

Loewer S; Cabili MN; Guttman M: et al.  2010.  Large intergenic non-coding RNA-RoR modeulates reprogramming of human induced pluripotent stem cells.  NATURE Genetics.  42(12):1113-   DOI: 10.1038/ng.710

Huarte M; Guttman M; Feldser D; et al.  2010.  A large intergenic noncoding RNA induced by p53 mediates global gene repression in thep53 response. Cell.  142(3):409-419.   DOI:10.1016/j.cell.2010.06.040

Guttman, M; Garber M; Levin JZ; et al.  2010.  Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs.  NATURE Biotechnology.  28(5):503-U166.  DOI: 10.1038/nbt.1633

Khalil AM; Guttman M; Huarte M; et al.  2009.  Many human large intergenic noncoding RNAs associate with Chromatin-modifying complexes and affect gene expression.  PNAS.  106(28):11667-11672   DOI: 10.1073/pnas.0904715106

Guttman M; Amit I; Garber M; et al.  2009.  Chromatin signature reveals over a thousand highly conserved large no-coding RNAs in mammals.  NATURE.  458(7235):223-227.  DOI: 10.1038/nature07672

 

Stem Cells, Signaling Pathways Identified in Lung Repair

Researchers at National Jewish Health have identified cells and signaling molecules that trigger the repair of injured lungs. Stijn De Langhe, PhD, and his colleagues report October 10, 2011, online in the Journal of Clinical Investigation, that destruction of lung tissue in mice induces smooth muscle cells surrounding the airways to secrete a protein known as fibroblast growth factor 10 (FGF10), which induces surviving epithelial cells in the airways to revert to a stem-cell state, proliferate, repair and repopulate the lining of the lungs.

U.K. Establishes New Stem Cell Center

The British government has given its approval for the creation of a £30 million stem cell therapy center, part of a £220 million program to turn British stem cell researchers’ discoveries into “a new multimillion-pound industry to help drive Britain’s recovery,” reports the Guardian‘s Rupert Neate. The stem cell center, which is slated to open in April 2012, will take advantage of the UK’s leadership in stem cell research, Neate says. The researchers will work to manufacture therapies for everything from Parkinson’s disease to prostate cancer. A third of the money will come from the British government, another third from the European Union, and the rest from companies like Pfizer and AstraZeneca, which are contracting to use part of the site where the center will be located. “It will have a test manufacturing facility to help labs convert a couple of grams of potentially life-saving cells into kilos of the stuff that can be sold commercially,” David Bott, director of innovation at the Technology Strategy Board, tells Neate.