Recommended Readings: Susan Kaech, Ph.D., September 14th

Monday Lecture Series
Monday, September 14th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Susan Kaech, Ph.D.
Associate Professor of Immunobiology,
Yale School of Medicine
Early Career Scientist,
Howard Hughes Medical Institute

PEPing Up T Cell-mediated Immunity to Viruses and Cancer

Recommended Readings

Empirical Articles

Cui, G., Staron, M. M., Gray, S. M., Ho, P. C., Amezquita, R. A., Wu, J., & Kaech, S. M. (2015). IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell, 161(4), 750-761. doi:10.1016/j.cell.2015.03.021.

Laidlaw, B. J., Cui, W., Amezquita, R. A., Gray, S. M., Guan, T., Lu, Y., … & Kaech, S. M. (2015). Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells. Nature Immunology, 16(8), 871-879. doi:10.1038/ni.3224

Laidlaw, B. J., Zhang, N., Marshall, H. D., Staron, M. M., Guan, T., Hu, Y., … & Kaech, S. M. (2014). CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity, 41(4), 633-645. doi:10.1016/j.immuni.2014.09.007.

Slütter, B., Pewe, L. L., Kaech, S. M., & Harty, J. T. (2013). Lung airway-surveilling CXCR3 hi memory CD8+ T cells are critical for protection against influenza A virus. Immunity, 39(5), 939-948. doi:10.1016/j.immuni.2013.09.013.

Review Paper

Gray, S. M., Kaech, S. M., & Staron, M. M. (2014). The interface between transcriptional and epigenetic control of effector and memory CD8+ T‐cell differentiation. Immunological Reviews, 261(1), 157-168. doi:10.1111/imr.12205.

Kaech, S. M., & Cui, W. (2012). Transcriptional control of effector and memory CD8+ T cell differentiation. Nature Reviews Immunology, 12(11), 749-761. doi:10.1038/nri3307.

Recommended Readings: Carl H. June, M.D., May 22nd

Friday Lecture Series
Friday, May 22, 2015
3:45 p.m., Caspary Auditorium

Carl H. June, M.D.
Director, Translational Research Program,
Abramson Family Cancer Research Institute
Richard W. Vague Professor in Immunotherapy,
Perelman School of Medicine,
University of Pennsylvania

Adoptive Cell Therapy with Engineered T Cells

Recommended Readings

Empirical Articles

Grupp, S. A., Kalos, M., Barrett, D., Aplenc, R., Porter, D. L., Rheingold, S. R., … & June, C. H. (2013). Chimeric antigen receptor–modified T cells for acute lymphoid leukemia. New England Journal of Medicine, 368(16), 1509-1518.  doi:10.1056/NEJMoa1215134

Kalos, M., Levine, B. L., Porter, D. L., Katz, S., Grupp, S. A., Bagg, A., & June, C. H. (2011). T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science Translational Medicine, 3(95), 95ra73-95ra73. doi:10.1126/scitranslmed.3002842

Porter, D. L., Levine, B. L., Kalos, M., Bagg, A., & June, C. H. (2011). Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia. New England Journal of Medicine, 365(8), 725-733. doi:10.1056/NEJMoa1103849

Review Papers

June, C. H., Maus, M. V., Plesa, G., Johnson, L. A., Zhao, Y., Levine, B. L., … & Porter, D. L. (2014). Engineered T cells for cancer therapy. Cancer Immunology, Immunotherapy, 63(9), 969-975. doi:10.1007/s00262-014-1568-1

Maus, M. V., Fraietta, J. A., Levine, B. L., Kalos, M., Zhao, Y., & June, C. H. (2014). Adoptive immunotherapy for cancer or viruses. Annual Review of Immunology, 32, 189-225. doi:10.1146/annurev-immunol-032713-120136

Recommended Readings: Gabriel Victora, Ph.D., March 9

Special Lecture
Monday, March 9, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gabriel Victora, Ph.D.
Principal Investigator,
Whitehead Fellow,
Whitehead Institute for Biomedical Research

Darwin in Miniature: Antibody Evolution in Germinal Centers

Recommended Readings

Empirical Articles

Schwickert, T. a, Victora, G. D., Fooksman, D. R., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., … Nussenzweig, M. C. (2011). A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. The Journal of Experimental Medicine, 208(6), 1243–1252. doi:10.1084/jem.20102477

Shulman, Z., Gitlin, A. D., Targ, S., Jankovic, M., Pasqual, G., Nussenzweig, M. C., & Victora, G. D. (2013). T follicular helper cell dynamics in germinal centers. Science, 341(6146), 673–677. doi:10.1126/science.1241680

Victora, G. D., Dominguez-sola, D., Holmes, A. B., Deroubaix, S., Dalla-favera, R., & Nussenzweig, M. C. (2012). Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood, 120(11), 2240–2248. doi:10.1182/blood-2012-03-415380.

Victora, G. D., Schwickert, T. a., Fooksman, D. R., Kamphorst, A. O., Meyer-Hermann, M., Dustin, M. L., & Nussenzweig, M. C. (2010). Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell, 143(4), 592–605. doi:10.1016/j.cell.2010.10.032

Review Papers

Victora, G. D., & Mesin, L. (2014). Clonal and cellular dynamics in germinal centers. Current Opinion in Immunology, 28, 90-96. doi:10.1016/j.coi.2014.02.010

Victora, G. D., & Nussenzweig, M. C. (2012). Germinal Centers. Annual Review of Immunology, 30, 429-457. doi:10.1146/annurev-immunol-020711-075032

Recommended Readings: Jean-Laurent Casanova, M.D., Ph.D., March 6

Friday Lecture Series / Ph.D. Recruitment Lecture
Friday, March 6, 2015
3:45 p.m., Caspary Auditorium

Jean-Laurent Casanova, M.D., Ph.D.,
Senior Attending Physician, Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Infectious Diseases of Childhood: Inborn Errors of Immunity?

Recommended Readings

Empirical Articles

Casrouge, A., Zhang, S.-Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., … Casanova, J.-L. (2006). Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314(5797), 308–312. doi:10.1126/science.1128346

Taramasso, L., Boisson-Dupuis, S., Garre, M. L., Bondi, E., Cama, a, Nozza, P., … Marazzi, M. G. (2014). Pineal germinoma in a child with interferon-gamma receptor 1 deficiency. case report and literature review. Journal of Clinical Immunology, 34(8), 922–927. doi:10.1007/s10875-014-0098-0

Von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C.-L., … Casanova, J.-L. (2008). Pyogenic bacterial infections in humans with MyD88 deficiency. Science, 321(5889), 691–696. doi:10.1126/science.1158298

Review Papers

Casanova, J.-L., & Abel, L. (2002). Genetic dissection of immunity to mycobacteria: the human model. Annual Review of Immunology, 20, 581–620. doi:10.1146/annurev.immunol.20.081501.125851

Casanova, J.-L., & Abel, L. (2013). The genetic theory of infectious diseases: a brief history and selected illustrations. Annual Review of Genomics and Human Genetics, 14, 215–243. doi:10.1146/annurev-genom-091212-153448

Conley, M. E., & Casanova, J. L. (2014). Discovery of single-gene inborn errors of immunity by next generation sequencing. Current Opinion in Immunology, 30, 17–23. doi:10.1016/j.coi.2014.05.004

Recommended Readings: Stephen C. Harrison, Ph.D. November 21

Friday Lecture Series
Friday, November 21, 2014,
3:45 p.m., Caspary Auditorium

Stephen C. Harrison, Ph.D.
Giovanni Armenise-Harvard Professor of Basic Medical Sciences,
Professor of Biological Chemistry and Molecular Pharmacology,
Professor of Pediatrics,
Director of the Center for Molecular and Cellular Dynamics,
Harvard Medical School
Head of the Laboratory of Molecular Medicine,
Children’s Hospital, Boston
Investigator,
Howard Hughes Medical Institute

Molecular Mechanisms of Membrane Penetration When Viruses Enter Cells

Recommended Readings

Empirical Articles

Abdelhakim, A. H., Salgado, E. N., Fu, X., Pasham, M., Nicastro, D., Kirchhausen, T., & Harrison, S. C. (2014). Structural correlates of rotavirus cell entry. PLoS Pathogens, 10(9), e1004355. doi:10.1371/journal.ppat.1004355

Ivanovic, T., Choi, J. L., Whelan, S. P., van Oijen, A. M., & Harrison, S. C. (2013). Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. eLife, 2(1), e00333. doi:10.7554/eLife.00333

Schmidt, A. G., Xu, H., Khan, A. R., O’Donnell, T., Khurana, S., King, L. R., … Harrison, S. C. (2013). Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences, 110(1), 264–269. doi:10.1073/pnas.1218256109

Review Article

Harrison, S. C. (2008). Viral membrane fusion. Nature Structural & Molecular Biology, 15(7), 690–698. doi:10.1038/nsmb.1456

The Much Maligned Tick: Key to a New Class of Antibiotics?

Yale researchers have discovered a glycoprotein in ticks (Ixodidae) that kicks in during winter to protect them from the cold also fights infection.  This protein may be the key to a new class of an antibiotics to help  in the battle against dangers pathogens such as MRSA.
Read more at: http://phys.org/news/2014-10-protein-infection.html#jCp

Recommended Readings: Diane Mathis, Ph.D.

Friday Lecture Series

The Ernst A.H. Friedheim Memorial Lecture

Aire, a Transcriptional Regulator Critical for Immunological Tolerance

Diane Mathis, Ph.D., professor, division of immunology,

department of microbiology and immunobiology, Harvard Medical School

March 21, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Abramson, J., Giraud, M., Benoist, C., & Mathis, D. (2010). Aire’s partners in the molecular control of immunological tolerance. Cell, 140(1), 123-135

Burzyn, D., Benoist, C., & Mathis, D. (2013). Regulatory T cells in nonlymphoid tissues. Nature Immunology, 14(10), 1007-1013

D’Alise, A. M., Ergun, A., Hill, J. A., Mathis, D., & Benoist, C. (2011). A cluster of coregulated genes determines TGF-β – induced regulatory T-cell (treg) dysfunction in NOD mice. Proceedings of the National Academy of Sciences of the United States of America, 108(21), 8737-8742

Fu, W., Ergun, A., Lu, T., Hill, J. A., Haxhinasto, S., Fassett, M. S., . . . Benoist, C. (2012). A multiply redundant genetic switch ‘locks in’ the transcriptional signature of regulatory T cells. Nature Immunology, 13(10), 972-980

Giraud, M., Yoshid, H., Abramson, J., Rahl, P. B., Young, R. A., Mathis, D., & Benoist, C. (2012). Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 535-540

Koh, A. S., Kingston, R. E., Benoist, C., & Mathis, D. (2010). Global relevance of aire binding to hypomethylated lysine-4 of histone-3. Proceedings of the National Academy of Sciences of the United States of America, 107(29), 13016-13021

Yang, S., Bansal, K., Lopes, J., Benoist, C., & Mathis, D. (2013). Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proceedings of the National Academy of Sciences of the United States of America, 110(5), 1833-1838

 

Recommended Readings: Michael Strand, Ph.D.

Friday Lecture Series

Polydnaviruses: Viral Mutualists and Nature’s Genetic Engineers

Michael Strand, Ph.D., Regents Professor, department of entomology,

University of Georgia

February 21, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Beck, M. H., & Strand, M. R. (2007). A novel polydnavirus protein inhibits the insect prophenoloxidase activation pathway. Proceedings of the National Academy of Sciences of the United States of America, 104(49), 19267-19272

Burke, G. R., Thomas, S. A., Eum, J. H., & Strand, M. R. (2013). Mutualistic polydnaviruses share essential replication gene functions with pathogenic ancestors. PLoS Pathogens, 9(5)

Strand, M. R., & Burke, G. R. (2012). Polydnaviruses as symbionts and gene delivery systems. PLoS Pathogens, 8(7), 5

Thoetkiattikul, H., Beck, M. H., & Strand, M. R. (2005). Inhibitor κB-like proteins from a polydnavirus inhibit NF-κB activation and suppress the insect immune response. Proceedings of the National Academy of Sciences of the United States of America, 102(32), 11426-11431

Webb, B. A., Strand, M. R., Dickey, S. E., Beck, M. H., Hilgarth, R. S., Barney, W. E., . . . Witherell, R. A. (2006). Polydnavirus genomes reflect their dual roles as mutualists and pathogens. Virology, 347(1), 160-174

 

Recommended Readings: Max Cooper, M.D.

Friday Lecture Series

How Did Our Adaptive Immune System Evolve?

Max Cooper, M.D., professor, Emory Vaccine Center and Emory Center for AIDS Research, Emory University School of Medicine

January 31, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Alder, M. N., Rogozin, I. B., Iyer, L. M., Glazko, G. V., Cooper, M. D., & Pancer, Z. (2005). Immunology: Diversity and function of adaptive immune receptors in a jawless vertebrate. Science, 310(5756), 1970-1973

Cooper, M. D. (2010). A life of adventure in immunobiology. Annual Review of Immunology 28, 11-19

Cooper, M. D., & Herrin, B. R. (2010). How did our complex immune system evolve? Nature Reviews Immunology, 10(1), 2-3

Guo, P., Hirano, M., Herrin, B. R., Li, J., Yu, C., Sadlonova, A., & Cooper, M. D. (2009). Dual nature of the adaptive immune system in lampreys. Nature, 459(7248), 796-801

Hirano, M., Das, S., Guo, P., & Cooper, M. D. (2011). The evolution of adaptive immunity in vertebrates. Advances in Immunology 109, pp. 125-157

Pancer, Z., & Cooper, M. D. (2006). The evolution of adaptive immunity. Annual Review of Immunology 24 , pp. 497-518

 

Recommended Readings: Poornima Parameswaran Ph.D. February 10

SPECIAL SEMINAR
Monday, February 10, 2014
4:00 p.m., Carson Family Auditorium

Poornima Parameswaran, Ph.D.

Postdoctoral Research Fellow
School of Public Health
University of California, Berkeley

Virome & Immunome Diversity in Dengue & other Infectious Diseases

Recommended Readings:

Empirical Papers

Parameswaran, P., Charlebois, P., Tellez, Y., Nunez, A., Ryan, E. M., Malboeuf, C. M., … Henn, M. R. (2012). Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity. Journal of Virology, 86(16), 8546–8558. doi:10.1128/JVI.00736-12

Parameswaran, P., Liu, Y., Roskin, K. M., Jackson, K. K. L., Dixit, V. P., Lee, J.-Y., … Fire, A. Z. (2013). Convergent antibody signatures in human dengue. Cell Host & Microbe, 13(6), 691–700. doi:10.1016/j.chom.2013.05.008

Parameswaran, P., Sklan, E., Wilkins, C., Burgon, T., Samuel, M. a, Lu, R., … Fire, A. Z. (2010). Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS pathogens, 6(2), e1000764. doi:10.1371/journal.ppat.1000764

Review Articles

Fontana, J. M., Alexander, E., & Salvatore, M. (2012). Translational research in infectious disease: current paradigms and challenges ahead. Translational Research, 159(6), 430–453. doi:10.1016/j.trsl.2011.12.009

Wylie, K. M., Weinstock, G. M., & Storch, G. a. (2012). Emerging view of the human virome. Translational Research, 160(4), 283–290. doi:10.1016/j.trsl.2012.03.006