Recommended Readings: Maria M. Mota PhD March 13, 2013

Posted on March 13, 2013 by Carol Feltes

Special Seminar Series

Malaria Infection, Superinfection and Co-infections: From Simple Models to Complex Interactions

Maria M. Mota, PH.D.

Unit Leader, Malaria Unit

Instituto de Medicina Molecular

Monday March 18, 2013

Recommended Readings:

Pinkevych, Mykola; Petravic, Janka; Chelimo, Kiprotich; et al. 2012. The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection. PLOS COMPUTATIONAL BIOLOGY. 8(10): e1002729 DOI: 10.1371/journal.pcbi.1002729

Klein, Eili Y.; Smith, David L.; Laxminarayan, Ramanan; et al. 2012. Superinfection and the evolution of resistance to antimalarial drugs. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 279( 1743):3834-3842 DOI: 10.1098/rspb.2012.1064

Portugal, Silvia; Drakesmith, Hal; Mota, Maria M. 2011. Superinfection in malaria: Plasmodium shows its iron will. EMBO REPORTS. 12(12):1233-1242 DOI: 10.1038/embor.2011.213

van Santen, Susanne; de Mast, Quirijn; Swinkels, Dorine W.; et al. 2011. Hepcidin in malaria superinfection: can findings be translated to humans? NATURE MEDICINE. 17(11):1341-1341 DOI: 10.1038/nm.2488

Portugal, Silvia; Carret, Celine; Recker, Mario; et al. 2011. Host-mediated regulation of superinfection in malaria. NATURE MEDICINE. 17(6):732-U126 DOI: 10.1038/nm.2368

Templeton, TJ; Keister, DB; Muratova, O; et al. 1998. Adherence of erythrocytes during exflagellation of Plasmodium falciparum microgametes is dependent on erythrocyte surface sialic acid and glycophorins. JOURNAL OF EXPERIMENTAL MEDICINE. 187(10 ):1599-1609 DOI: 10.1084/jem.187.10.1599

Recommended Readings: Michel C. Nussenzweig, M.D., Ph.D.

Posted on March 7, 2013 by Olga Nilova

Friday Lecture Series

Ph.D. Recruitment Lecture

The HIV Vaccine Problem

Michel C. Nussenzweig, M.D., Ph.D., Sherman Fairchild Professor,

senior physician, The Rockefeller University;

investigator, Howard Hughes Medical Institute

March 8, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Mouquet, H., Warncke, M., Scheid, J. F., Seaman, M. S., & Nussenzweig, M. C. (2012). Enhanced HIV-1 neutralization by antibody heteroligation. Proceedings of the National Academy of Sciences of the United States of America, 109(3), 875-880

Nchinda, G., Kuroiwa, J., Oks, M., Trumpfheller, C., Chae, G. P., Huang, Y., . . . Steinman, R. M. (2008). The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. Journal of Clinical Investigation, 118(4), 1427-1436

Scheid, J. F., Mouquet, H., Ueberheide, B., Diskin, R., Klein, F., Oliveira, T. Y. K., . . . Nussenzweig, M. C. (2011). Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science, 333(6049), 1633-1637

Trumpfheller, C., Finke, J. S., López, C. B., Moran, T. M., Moltedo, B., Soares, H., . . . Steinman, R. M. (2006). Intensified and protective CD4 + T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. Journal of Experimental Medicine, 203(3), 607-617

Zhou, T., Georgiev, I., Wu, X., Yang, Z. -., Dai, K., Finzi, A., . . . Kwong, P. D. (2010). Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science, 329(5993), 811-817

Recommended Readings: Beatrice H. Hahn, M.D.

Posted on January 23, 2013 by Olga Nilova

Friday Lecture Series

Maclyn McCarty Memorial Lecture

Great Ape Reservoirs of Human AIDS and Malaria

Beatrice H. Hahn, M.D., professor, departments of medicine and microbiology,

University of Pennsylvania

January 25, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Keele, B. F., J. H. Jones, K. A. Terio, J. D. Estes, R. S. Rudicell, M. L. Wilson, Y. Li, et al. 2009. “Increased Mortality and AIDS-Like Immunopathology in Wild Chimpanzees Infected with SIVcpz.” Nature 460 (7254): 515-519

Lee, H. Y., E. E. Giorgi, B. F. Keele, B. Gaschen, G. S. Athreya, J. F. Salazar-Gonzalez, K. T. Pham, et al. 2009. “Modeling Sequence Evolution in Acute HIV-1 Infection.” Journal of Theoretical Biology 261 (2): 341-360

Liu, J., B. F. Keele, H. Li, S. Keating, P. J. Norris, A. Carville, K. G. Mansfield, et al. 2010. “Low-Dose Mucosal Simian Immunodeficiency Virus Infection Restricts Early Replication Kinetics and Transmitted Virus Variants in Rhesus Monkeys.” Journal of Virology 84 (19): 10406-10412

Liu, W., Y. Li, G. H. Learn, R. S. Rudicell, J. D. Robertson, B. F. Keele, J. -B N. Ndjango, et al. 2010. “Origin of the Human Malaria Parasite Plasmodium Falciparum in Gorillas.” Nature 467 (7314): 420-425

Rayner, J. C., W. Liu, M. Peeters, P. M. Sharp, and B. H. Hahn. 2011. “A Plethora of Plasmodium Species in Wild Apes: A Source of Human Infection?” Trends in Parasitology 27 (5): 222-229

Sharp, P. M. and B. H. Hahn. 2010. “The Evolution of HIV-1 and the Origin of AIDS.” Philosophical Transactions of the Royal Society B: Biological Sciences 365 (1552): 2487-2494

Recommended Readings: Yanick Crow, PhD September 17, 2012

Posted on September 6, 2012 by Carol Feltes

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Human Type I Interferonopathies

Yanick Crow PhD

Professor of Genetic Medicine

University of Manchester, UK

Monday, September 17, 2012

4 p.m. , Caspary Auditorium. Refreshments 3:45 p.m.

Recommended Review:

Banchereau, J; Pascual, V. 2006. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. IMMUNITY. 25( 3):383-392. DOI: 10.1016/j.immuni.2006.08.010

Recommended Readings:

Crow, Y. 2011. Type I interferonopathies: a novel set of inborn errors of immunity. Annals of the New York Academy of Sciences 1238: 91-98. DOI: 10.1111/j.1749-6632.2011.06220.x

Briggs, Tracy A.; Rice, Gillian I.; Daly, Sarah; et al. 2011. Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. NATURE GENETICS 43(2):127-U71. DOI: 10.1038/ng.748

Alcais, A; Quintana-Murci, L; Thaler, DS.; et al. 2010. Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity? Annals of the New York Academy of Sciences 1214:18-33. DOI: 10.1111/j.1749-6632.2010.05834.x

Crow, Yanick J. 2011. Lupus: How much “complexity” is really (just) genetic heterogeneity? ARTHRITIS AND RHEUMATISM. 63(12): 3661-3664 DOI: 10.1002/art.30603

Crow, Y.; Rehwinkel, J. 2009. Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity. HUMAN MOLECULAR GENETICS 18: R130-R136. DOI: 10.1093/hmg/ddp293

Baechler, EC; Batliwalla, FM; Karypis, G; et al. 2003. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100( 5):2610-2615. DOI: 10.1073/pnas.0337679100

Recommended Readings: Howard C Hang, PhD.

Posted on May 17, 2012 by Carol Feltes

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Chemical Reporters for Exploring Posttranslational

Modifications in Innate Immunity

Howard C Hang, Ph.D.

Laboratory of Chemical Biology and Microbial Pathogenesis

The Rockefeller University

4:00 p.m. Monday, June 4, 2012 Refreshments 3:45 Abby Lounge

Caspary Auditorium

Recommended Readings

Yount JS, Charron G, Hang HC. 2012. Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetis enzymes. Bioorganic & Medicinal Chemistry. 20(2, S1):650-654. DOI: 0.1016/j.bmc.2011.03.062

Lei YL, Xie K. et al. 2012. Chemistry-based functional proteomics to identify novel deubiquitylating enzymes involved in viral infection. Combinatorial Chemistry & High Throughput Screening. 15(4):316-327. Please request from Markus Library.

Grammel M, Dossa PD, Taylor-Salmon E, et al. 2012. II-selective labeling of bacterial proteomes with an orthogonal phenylalanine amino acid reporter. Chemical Communications. 48(10):1473-1474. DOI: 10.1039/c1cc14939c

Aguera-Gonzales S, Gross CC, Fernandez-Messina L, et al. 2011. Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding. European Journal of Immunology. 41(12):3667-3676. DOI: 10.1002/eji.20114165

Hao ZY, Hong SL, Chen X, et al. 2011. Introducing bioorthogonal functionalities into proteins in living cells. Accounts of Chemical Research 44(9, S1):742-751. DOI: 10.1021/ar200067r

Hang HC, Linder ME. 2011. Exploring protein lipidation with chemical biology. Chemical Reviews. 111(10):6341-6358. DOI: 10.1021/cr2001977

Yang YY, Hang HC. 2011. Chemical approaches for the detection and synthesis of acetylated proteins. Chembiochem. 12(2):314-322. DOI: 10.1002/cbc.201000558

Biologists Produce Malaria Vaccine From Algae

Posted on May 17, 2012 by Carol Feltes

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Biologists at the University of California, San Diego have succeeded in engineering algae to produce potential candidates for a vaccine that would prevent transmission of the parasite that causes malaria, an achievement that could pave the way for the development of an inexpensive way to protect billions of people from one of the world’s most prevalent and debilitating diseases. Initial proof-of-principle experiments suggest that such a vaccine could prevent malaria transmission. Read the report of their research in PLoS ONE.

Recommended Readings: Bruce Walker, M.D.

Posted on April 11, 2012 by Olga Nilova

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Friday Lecture Series

Immune Control and Immune Failure in HIV Infection

Bruce Walker, M.D., Principal Investigator,

Ragon Institute of MGH, MIT and Harvard

April 13, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Huang, J., P. S. Burke, T. D. H. Cung, F. Pereyra, I. Toth, B. D. Walker, L. Borges, M. Lichterfeld, and X. G. Yu. 2010. “Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers.” Journal of Virology 84 (18): 9463-9471

Kawashima, Y., K. Pfafferott, J. Frater, P. Matthews, R. Payne, M. Addo, H. Gatanaga, et al. 2009. “Adaptation of HIV-1 to Human Leukocyte Antigen Class I.” Nature 458 (7238): 641-645

Mahalanabis, M., P. Jayaraman, T. Miura, F. Pereyra, E. M. Chester, B. Richardson, B. Walker, and N. L. Haigwood. 2009. “Continuous Viral Escape and Selection by Autologous Neutralizing Antibodies in Drug-Naïve Human Immunodeficiency Virus Controllers.” Journal of Virology 83 (2): 662-672

Matthews, P. C., A. Prendergast, A. Leslie, H. Crawford, R. Payne, C. Rousseau, M. Rolland, et al. 2008. “Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point.” Journal of Virology 82 (17): 8548-8559

Pereyra, F., S. Palmer, T. Miura, B. L. Block, A. Wiegand, A. C. Rothchild, B. Baker, et al. 2009. “Persistent Low-Level Viremia in HIV-1 Elite Controllers and Relationship to Immunologic Parameters.” Journal of Infectious Diseases 200 (6): 984-990

Virgin, H. W. and B. D. Walker. 2010. “Immunology and the Elusive AIDS Vaccine.” Nature 464 (7286): 224-231

Recommended Readings: Jason Cyster, Ph.D.

Posted on March 14, 2012 by Olga Nilova

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Friday Lecture Series

Sphingolipids and Oxysterols in B Cell Immunity and Cancer

Jason Cyster, Ph.D., Professor, Department of Microbiology and Immunology,

University of California, San Francisco

March 16, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Cinamon, G., M. A. Zachariah, O. M. Lam, F. W. Foss Jr., and J. G. Cyster. 2008. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nature immunology 9, (1): 54-62

Cyster, J. G. 2005. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annual Review of Immunology 23 , pp. 127-159

Okada, T., and J. G. Cyster. 2006. B cell migration and interactions in the early phase of antibody responses. Current opinion in immunology 18, (3): 278-285

Pappu, R., S. R. Schwab, I. Cornelissen, J. P. Pereira, J. B. Regard, Y. Xu, E. Camerer, et al. 2007. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316, (5822): 295-298

Pham, T. H. M., P. Baluk, Y. Xu, I. Grigorova, A. J. Bankovich, R. Pappu, S. R. Coughlin, D. M. McDonald, S. R. Schwab, and J. G. Cyster. 2010. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. Journal of Experimental Medicine 207, (1): 17-27

Randall, K. L., T. Lambe, A. Johnson, B. Treanor, E. Kucharska, H. Domaschenz, B. Whittle, et al. 2009. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nature immunology 10, (12): 1283-1291

Recommended Readings: Jeffrey V. Ravetch, Ph. D.

Posted on March 8, 2012 by Olga Nilova

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Friday Lecture Series

The Paradox of Immunity

Jeffrey V. Ravetch, M.D., Ph.D., Theresa and Eugene M. Lang Professor and head,

Leonard Wagner Laboratory of Molecular Genetics and Immunology,

The Rockefeller University

March 9, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Anthony, R. M., F. Nimmerjahn, D. J. Ashline, V. N. Reinhold, J. C. Paulson, and J. V. Ravetch. 2008. Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG fc. Science 320, (5874): 373-376

Durandy, A., S. V. Kaveri, T. W. Kuijpers, M. Basta, S. Miescher, J. V. Ravetch, and R. Rieben. 2009. Intravenous immunoglobulins-understanding properties and mechanisms. Clinical and experimental immunology 158, (SUPPL. 1): 2-13

Nimmerjahn, F., and J. V. Ravetch. 2010. Antibody-mediated modulation of immune responses. Immunological reviews 236, (1): 265-275

Ravetch, J. 2010. In vivo veritas: The surprising roles of fc receptors in immunity. Nature immunology 11, (3): 183-185

Sazinsky, S. L., R. G. Ott, N. W. Silver, B. Tidor, J. V. Ravetch, and K. D. Wittrup. 2008. Aglycosylated immunoglobulin G1 variants productively engage activating fc receptors. Proceedings of the National Academy of Sciences of the United States of America 105, (51): 20167-20172

New Open Access Database: antibodypedia

Posted on February 16, 2012 by Carol Feltes

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Antibodypedia is a searchable, open-access resource reporting data and commentary on the efficacy of publicly available antibodies which detect human protein targets. The site features user and provider data for antibody efficacy in a range of biochemical and cell biological techniques.