Recommended Readings: Luciano Marraffini, Ph.D., Friday October 20th, 2017

Friday Lectures

Friday, October 20, 2017  3:45 p.m.

Caspary Auditorium

Luciano Marraffini, Ph.D.

Associate Professor and Head

Laboratory of Bacteriology

The Rockefeller University

CRISPR-Cas, Acquired Immunity in Prokaryotes

 

Recommended Readings:

Niewoehner, Ole; Garcia-Doval, Carmela; Rostol, Jakob T.; et al. (2017). Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.  NATURE. 548 (7669): 543-+

Modell, Joshua W.; Jiang, Wenyan; Marraffini, Luciano A. (2017). CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity. NATURE. 544 (7648): 101-+  

Marraffini, Luciano A. (2017). Sensing danger. PNAS. 114 (1): 15-16

Heler, Robert; Wright, Addison V.; Vucelja, Marija; et al. (2017). Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. MOLECULAR CELL. 65 (1): 168-175

Marraffini, Luciano A. (2015). CRISPR-Cas immunity in prokaryotes. NATURE. 526 (7571): 55-61

McGinn, Jon; Marraffini, Luciano A. (2016). CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration. MOLECULAR CELL. 64 (3): 616-623

Barrangou, Rodolphe; Marraffini, Luciano A. (2014). CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity. MOLECULAR CELL. 54 (2): 234-244

Cong, Le; Ran, F. Ann; Cox, David; et al. (2013). Multiplex Genome Engineering Using CRISPR/Cas Systems.  SCIENCE. 339 (6121): 819-823

 

 

Recommended Readings: James P. Allison, Ph.D., Friday May 12th, 2017

Friday Lectures

Friday, May 2, 2017  3:45 p.m.

Caspary Auditorium

James P. Allison, Ph.D.

Professor and Vivian L. Smith Distinguished Chair of Immunology,

Executive Director of the Immunotherapy Platform

The University of Texas MD Anderson Cancer Center

Immune Checkpoint Blockade in Cancer Therapy: New Insights, Opportunities, and Prospects for a Cure

Recommended Readings:

http://thetartan.org/2017/5/1/scitech/immunotherapy

Hazarika M; Chuk MK; Theoret MR; et al. (2017). U.S. FDA Approval Summary: Nivolumab for Treatment of Unresectable or Metastatic Melanoma Following Progression on Ipilimumab.CLINICAL CANCER RESEARCH. doi: 10.1158/1078-0432

Medina, Patrick J.; Adams, Val R. (2016). PD-1 Pathway Inhibitors: Immuno-Oncology Agents for Restoring Antitumor Immune Responses. PHARMACOTHERAPY. 36(3): 317-334

Sharma, Padmanee; Allison, James P. (2015). Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential. CELL. 161(2): 205-214

Robert, Caroline; Schachter, Jacob; Long, Georgina V.; et al. (2015). Pembrolizumab versus Ipilimumab in Advanced Melanoma. NEW ENGLAND JOURNAL OF MEDICINE    372(26): 2521-2532

Sharma, Padmanee; Allison, James P. (2015). The future of immune checkpoint therapy. SCIENCE. 348(6230): 56-61

Gubin, Matthew M.; Zhang, Xiuli; Schuster, Heiko; et al. (2014). Checkpoint blockage cancer immunotherapy targets tumour-specific mutant antigens. NATURE. 515(7528): 577-+

Lipson, Evan J.; Drake, Charles G. (2011). Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma. CLINICAL CANCER RESEARCH. 17(22): 6958-6962

 

Recommended Readings: Vincent A. Fischetti, Ph.D. April 24, 2017

Monday Lectures

Monday, April 17, 2017  3:45 p.m.

Carson Family Auditorium

Vincent A. Fischetti, Ph.D.

Professor and Head,

Laboratory of Bacterial Pathogenesis and Immunology

The Rockefeller University

Exploiting phage evolution for the development of novel therapeutics

Recommended Readings:

David Bautz. March 20th 2017. CFRX: Phase 2 Trial of CF-301 to Initiate in mid-2017.

Czaplewski, Lloyd; Bax, Richard; Clokie, Martha; et al. (2016). Alternatives to antibiotics-a pipeline portfolio review. LANCET INFECTIOUS DISEASES. 16(2): 239-251

Diez-Martinez, Roberto; De Paz, Hector D.; Garcia-Fernandez, Esther; et al. (2015). A novel chimeric phage lysin with high in vitro and in vivo bactericidal activity against Streptococcus pneumoniae. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 70(6): 1763-1773

Bikard, David; Euler, Chad W.; Jiang, Wenyan; et al. (2014). Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. NATURE BIOTECHNOLOGY. 32(11): 1146-1150

Schuch, Raymond; Lee, Han M.; Schneider, Brent C.; et al. (2014). Combination Therapy With Lysin CF-301 and Antibiotic Is Superior to Antibiotic Alone for Treating Methicillin-Resistant Staphylococcus aureus-Induced Murine Bacteremia. JOURNAL OF INFECTIOUS DISEASES. 209(9): 1469-1478

Pastagia, Mina; Schuch, Raymond; Fischetti, Vincent A.; et al. (2013). Lysins: the arrival of pathogen-directed anti-infectives. JOURNAL OF MEDICAL MICROBIOLOGY. 62:1506-1516

Gilmer, Daniel B.; Schmitz, Jonathan E.; Euler, Chad W.; et al. (2013). Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 57(6): 2743-2750

 
 

Recommended Readings: Ian A. Wilson D. Phil., D. Sci., Friday February 10, 2017

Friday Lectures

Friday, February 10, 2017   3:45 p.m.

Caspary Auditorium

Ian A. Wilson  D. Phil., D.Sci.

Hansen Professor of Structural Biology, and

Chair, Dept. of Integrative Structural and Computational Biology

The Scripps Research Institute

Broad Neutralization of Influenza Viruses and

Implications for a Universal Vaccine and Therapy

Recommended Readings:

Dreyfus, Cyrille; Laursen, Nick S.; Kwaks, Ted; et al.  (2012). Highly Conserved Protective Epitopes on Influenza B Viruses.  SCIENCE, 337(6100): 1343-1348 

Walker, Laura M.; Huber, Michael; Doores, Katie J.; et al. (2011).  Broad neutralization coverage of HIV by multiple highly potent antibodiesNATURE , 477(7365): 466-U117

Ekiert, Damian C.; Friesen, Robert H. E.; Bhabha, Gira; et al. (2011).  A Highly Conserved Neutralizing Epitope on Group 2 Influenza A VirusesSCIENCE,  333(6044): 843-850 

Gottlieb, Tanya; Ben-Yedidia, Tamar.  (2014)  Epitope-based approaches to a universal influenza vaccine.  JOURNAL OF AUTOIMMUNITY.  54 (Special Issue: SI ):15-20 

He, Fang; Prabakaran, Mookkan; Kumar, Subaschandrabose Rajesh; et al. (2011), Monovalent H5 vaccine based on epitope-chimeric HA provides broad cross-clade protection against variant H5N1 viruses in miceANTIVIRAL RESEARCH,  105: 143-151 

Li, Zhuo; Gabbard, Jon D.; Mooney, Alaina; et al. (2013). Single-Dose Vaccination of a Recombinant Parainfluenza Virus 5 Expressing NP from H5N1 Virus Provides Broad Immunity against Influenza A Viruses.  JOURNAL OF VIROLOGY,  87(10): 5985-5993

Huber, Victor C.; Thomas, Paul G.; McCullers, Jonathan A. (2009).  A multi-valent vaccine approach that elicits broad immunity within an influenza subtypeVACCINE,  27(8): 1192-1200

Recommended Readings: Elena Gallo MacFarlane, Ph.D., February 8

Special Seminar
Wednesday, February 8, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Elena Gallo MacFarlane, Ph.D.
Postdoctoral and Research Fellow,
Institute of Genetic Medicine,
Johns Hopkins University School of Medicine

The Vessel Wall as a Paracrine Engine in TGF-Beta-Driven Vasculopathies

Recommended Reading:

Chetaille, P., Preuss, C., Burkhard, S., Côté, J. M., Houde, C., Castilloux, J., … & Thibeault, M. (2014). Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature Genetics, 46(11), 1245-1249. doi: 10.1038/ng.3113.

Gallo, E. M., Loch, D. C., Habashi, J. P., Calderon, J. F., Chen, Y., Bedja, D., … & Judge, D. P. (2014). Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. The Journal of Clinical Investigation, 124(1), 448-460. doi: 10.1172/JCI69666.

Gerber, E. E., Gallo, E. M., Fontana, S. C., Davis, E. C., Wigley, F. M., Huso, D. L., & Dietz, H. C. (2013). Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma. Nature, 503(7474), 126-130. doi: 10.1038/nature12614.
Chicago

Lindsay, M. E., Schepers, D., Bolar, N. A., Doyle, J. J., Gallo, E., Fert-Bober, J., … & Bjeda, D. (2012). Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm. Nature Genetics, 44(8), 922-927. doi: 10.1038/ng.2349

Recommended Readings: Michael Lenardo, M.D., October 23rd

Friday Lecture Series
Friday, October 23, 2015
3:45 p.m., Caspary Auditorium

Michael Lenardo, M.D.
Chief, Molecular Development Section,
Laboratory of Immunology,
Director, NIAID Clinical Genomics Program,
National Institute of Allergy and Infectious Diseases,
National Institutes of Health

Genomic Approaches to Solving Primary Immune Disorders

Recommended Readings

Empirical Articles

Kuehn, H. S., Ouyang, W., Lo, B., Deenick, E. K., Niemela, J. E., Avery, D. T., … & Uzel, G. (2014). Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science, 345(6204), 1623-1627. doi:10.1126/science.1255904.

Lo, B., Zhang, K., Lu, W., Zheng, L., Zhang, Q., Kanellopoulou, C., … & Jordan, M. B. (2015). Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science, 349(6246), 436-440. doi:10.1126/science.aaa1663.

Lucas, C. L., Zhang, Y., Venida, A., Wang, Y., Hughes, J., McElwee, J., … & Lenardo, M. J. (2014). Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K. The Journal of Experimental Medicine, 211(13), 2537-2547. doi:10.1084/jem.20141759.

Review Papers

Grönholm, J., & Lenardo, M. J. (2015). Novel diagnostic and therapeutic approaches for autoimmune diabetes- A prime time to treat insulitis as a disease. Clinical Immunology, 156(2), 109-118. doi:10.1016/j.clim.2014.11.007.

Zhang, Y., Su, H. C., & Lenardo, M. J. (2015). Genomics is rapidly advancing precision medicine for immunological disorders. Nature Immunology, 16(10), 1001-1004. doi:10.1038/ni.3275

Recommended Readings: Susan Kaech, Ph.D., September 14th

Monday Lecture Series
Monday, September 14th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Susan Kaech, Ph.D.
Associate Professor of Immunobiology,
Yale School of Medicine
Early Career Scientist,
Howard Hughes Medical Institute

PEPing Up T Cell-mediated Immunity to Viruses and Cancer

Recommended Readings

Empirical Articles

Cui, G., Staron, M. M., Gray, S. M., Ho, P. C., Amezquita, R. A., Wu, J., & Kaech, S. M. (2015). IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell, 161(4), 750-761. doi:10.1016/j.cell.2015.03.021.

Laidlaw, B. J., Cui, W., Amezquita, R. A., Gray, S. M., Guan, T., Lu, Y., … & Kaech, S. M. (2015). Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells. Nature Immunology, 16(8), 871-879. doi:10.1038/ni.3224

Laidlaw, B. J., Zhang, N., Marshall, H. D., Staron, M. M., Guan, T., Hu, Y., … & Kaech, S. M. (2014). CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity, 41(4), 633-645. doi:10.1016/j.immuni.2014.09.007.

Slütter, B., Pewe, L. L., Kaech, S. M., & Harty, J. T. (2013). Lung airway-surveilling CXCR3 hi memory CD8+ T cells are critical for protection against influenza A virus. Immunity, 39(5), 939-948. doi:10.1016/j.immuni.2013.09.013.

Review Paper

Gray, S. M., Kaech, S. M., & Staron, M. M. (2014). The interface between transcriptional and epigenetic control of effector and memory CD8+ T‐cell differentiation. Immunological Reviews, 261(1), 157-168. doi:10.1111/imr.12205.

Kaech, S. M., & Cui, W. (2012). Transcriptional control of effector and memory CD8+ T cell differentiation. Nature Reviews Immunology, 12(11), 749-761. doi:10.1038/nri3307.

Recommended Readings: Carl H. June, M.D., May 22nd

Friday Lecture Series
Friday, May 22, 2015
3:45 p.m., Caspary Auditorium

Carl H. June, M.D.
Director, Translational Research Program,
Abramson Family Cancer Research Institute
Richard W. Vague Professor in Immunotherapy,
Perelman School of Medicine,
University of Pennsylvania

Adoptive Cell Therapy with Engineered T Cells

Recommended Readings

Empirical Articles

Grupp, S. A., Kalos, M., Barrett, D., Aplenc, R., Porter, D. L., Rheingold, S. R., … & June, C. H. (2013). Chimeric antigen receptor–modified T cells for acute lymphoid leukemia. New England Journal of Medicine, 368(16), 1509-1518.  doi:10.1056/NEJMoa1215134

Kalos, M., Levine, B. L., Porter, D. L., Katz, S., Grupp, S. A., Bagg, A., & June, C. H. (2011). T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science Translational Medicine, 3(95), 95ra73-95ra73. doi:10.1126/scitranslmed.3002842

Porter, D. L., Levine, B. L., Kalos, M., Bagg, A., & June, C. H. (2011). Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia. New England Journal of Medicine, 365(8), 725-733. doi:10.1056/NEJMoa1103849

Review Papers

June, C. H., Maus, M. V., Plesa, G., Johnson, L. A., Zhao, Y., Levine, B. L., … & Porter, D. L. (2014). Engineered T cells for cancer therapy. Cancer Immunology, Immunotherapy, 63(9), 969-975. doi:10.1007/s00262-014-1568-1

Maus, M. V., Fraietta, J. A., Levine, B. L., Kalos, M., Zhao, Y., & June, C. H. (2014). Adoptive immunotherapy for cancer or viruses. Annual Review of Immunology, 32, 189-225. doi:10.1146/annurev-immunol-032713-120136

Recommended Readings: Gabriel Victora, Ph.D., March 9

Special Lecture
Monday, March 9, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gabriel Victora, Ph.D.
Principal Investigator,
Whitehead Fellow,
Whitehead Institute for Biomedical Research

Darwin in Miniature: Antibody Evolution in Germinal Centers

Recommended Readings

Empirical Articles

Schwickert, T. a, Victora, G. D., Fooksman, D. R., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., … Nussenzweig, M. C. (2011). A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. The Journal of Experimental Medicine, 208(6), 1243–1252. doi:10.1084/jem.20102477

Shulman, Z., Gitlin, A. D., Targ, S., Jankovic, M., Pasqual, G., Nussenzweig, M. C., & Victora, G. D. (2013). T follicular helper cell dynamics in germinal centers. Science, 341(6146), 673–677. doi:10.1126/science.1241680

Victora, G. D., Dominguez-sola, D., Holmes, A. B., Deroubaix, S., Dalla-favera, R., & Nussenzweig, M. C. (2012). Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood, 120(11), 2240–2248. doi:10.1182/blood-2012-03-415380.

Victora, G. D., Schwickert, T. a., Fooksman, D. R., Kamphorst, A. O., Meyer-Hermann, M., Dustin, M. L., & Nussenzweig, M. C. (2010). Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell, 143(4), 592–605. doi:10.1016/j.cell.2010.10.032

Review Papers

Victora, G. D., & Mesin, L. (2014). Clonal and cellular dynamics in germinal centers. Current Opinion in Immunology, 28, 90-96. doi:10.1016/j.coi.2014.02.010

Victora, G. D., & Nussenzweig, M. C. (2012). Germinal Centers. Annual Review of Immunology, 30, 429-457. doi:10.1146/annurev-immunol-020711-075032

Recommended Readings: Jean-Laurent Casanova, M.D., Ph.D., March 6

Friday Lecture Series / Ph.D. Recruitment Lecture
Friday, March 6, 2015
3:45 p.m., Caspary Auditorium

Jean-Laurent Casanova, M.D., Ph.D.,
Senior Attending Physician, Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Infectious Diseases of Childhood: Inborn Errors of Immunity?

Recommended Readings

Empirical Articles

Casrouge, A., Zhang, S.-Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., … Casanova, J.-L. (2006). Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314(5797), 308–312. doi:10.1126/science.1128346

Taramasso, L., Boisson-Dupuis, S., Garre, M. L., Bondi, E., Cama, a, Nozza, P., … Marazzi, M. G. (2014). Pineal germinoma in a child with interferon-gamma receptor 1 deficiency. case report and literature review. Journal of Clinical Immunology, 34(8), 922–927. doi:10.1007/s10875-014-0098-0

Von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C.-L., … Casanova, J.-L. (2008). Pyogenic bacterial infections in humans with MyD88 deficiency. Science, 321(5889), 691–696. doi:10.1126/science.1158298

Review Papers

Casanova, J.-L., & Abel, L. (2002). Genetic dissection of immunity to mycobacteria: the human model. Annual Review of Immunology, 20, 581–620. doi:10.1146/annurev.immunol.20.081501.125851

Casanova, J.-L., & Abel, L. (2013). The genetic theory of infectious diseases: a brief history and selected illustrations. Annual Review of Genomics and Human Genetics, 14, 215–243. doi:10.1146/annurev-genom-091212-153448

Conley, M. E., & Casanova, J. L. (2014). Discovery of single-gene inborn errors of immunity by next generation sequencing. Current Opinion in Immunology, 30, 17–23. doi:10.1016/j.coi.2014.05.004