Recommended Readings: Joseph Schlessinger, Ph.D., May 13

Friday Lecture Series
Friday, May 13, 2016
3:45 p.m., Caspary Auditorium

Joseph Schlessinger, Ph.D.
William H. Prusoff Professor and Chair,
Department of Pharmacology,
Yale School of Medicine

Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy

Recommended Readings:

Empirical Articles

Bae, J. H., Lew, E. D., Yuzawa, S., Tomé, F., Lax, I., & Schlessinger, J. (2009). The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell, 138(3), 514-524. doi: 10.1016/j.cell.2009.05.028.

Chung, I., Akita, R., Vandlen, R., Toomre, D., Schlessinger, J., & Mellman, I. (2010). Spatial control of EGF receptor activation by reversible dimerization on living cells. Nature, 464(7289), 783-787. doi: 10.1038/nature08827.

Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., & Schlessinger, J. (2007). Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor. Cell, 130(2), 323-334.

Review Papers

Lemmon, M. A., & Schlessinger, J. (2010). Cell signaling by receptor tyrosine kinases. Cell, 141(7), 1117-1134. doi: 10.1016/j.cell.2010.06.011.

Schlessinger, J. (2014). Receptor tyrosine kinases: legacy of the first two decades. Cold Spring Harbor Perspectives in Biology, 6(3), a008912. doi: 10.1101/cshperspect.a008912.

Recommended Readings: Tony Hunter, Ph.D., April 29

Friday Lecture Series
Friday, April 29, 2016
3:45 p.m., Caspary Auditorium

Tony Hunter, Ph.D.
Director, Molecular and Cell Biology Laboratory,
Renato Dulbecco Chair in Cancer Research,
American Cancer Society Professor,
Salk Institute for Biological Studies

Post-translational regulation of cell signaling

Recommended Readings

Hunter, T. (2014). The genesis of tyrosine phosphorylation. Cold Spring Harbor Perspectives in Biology, 6(5), a020644. doi: 10.1101/cshperspect.a020644

Hunter, T. (2015). Discovering the first tyrosine kinase. Proceedings of the National Academy of Sciences, 112(26), 7877–7882. doi: 10.1073/pnas.1508223112

Recommended Readings: Pietro De Camilli, M.D., February 13

Friday Lecture Series
Friday, February 13, 2015
3:45 p.m., Caspary Auditorium

Pietro De Camilli, M.D.
John Klingenstein Professor of Neuroscience,
Professor of Cell Biology,
Director, Program in Cellular Neuroscience, Neurodegeneration, and Repair,
Yale University School of Medicine
Investigator, Howard Hughes Medical Institute

Lipid Signaling in the Control of Membrane Dynamics and Interactions

Recommended Readings

Empirical Articles

Giordano, F., Saheki, Y., Idevall-Hagren, O., Colombo, S. F., Pirruccello, M., Milosevic, I., … De Camilli, P. (2013). PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell, 153(7), 1494–1509. doi:10.1016/j.cell.2013.05.026

Schauder, C. M., Wu, X., Saheki, Y., Narayanaswamy, P., Torta, F., Wenk, M. R., … Reinisch, K. M. (2014). Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature, 510(7506), 552–555. doi:10.1038/nature13269

Wu, X., Chi, R., Baskin, J., Lucast, L., Burd, C., DeCamilli, P., & Reinisch, K. (2014). Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Developmental Cell, 28(1), 19–29. doi:10.1016/j.devcel.2013.11.012

Review Paper

Idevell-Hagren, O., & De Camilli, P. (In Press). Detection and manipulation of phosphoinositides. Biochimica et Biophysica Acta Journal. doi:10.1016/j.bbalip.2014.12.008

Recommended Readings: Jorge E. Galán, Ph.D., DVM, February 6

Friday Lecture Series
Friday, February 6, 2015
3:45 p.m., Caspary Auditorium

Jorge E. Galán, Ph.D., DVM
Lucille P. Markey Professor of Microbial Pathogenesis,
Professor of Cell Biology,
Chair, Department of Microbial Pathogenesis,
Yale University School of Medicine

Typhoid fever: new insight into the pathogenesis of an old disease

Recommended Readings

Empirical Articles

Lefebre, M. D., & Galán, J. E. (2014). The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Proceedings of the National Academy of Sciences, 111(2), 817–822. doi:10.1073/pnas.1319698111

Song, J., Gao, X., & Galán, J. E. (2013). Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature, 499(7458), 350–354. doi:10.1038/nature12377

Spanò, S., & Galán, J. E. (2012). A Rab32-dependent pathway contributes to Salmonella typhi host restriction. Science, 338(6109), 960–963. doi:10.1126/science.1229224

Review Papers

Hicks, S. W., & Galán, J. E. (2013). Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Nature Reviews Microbiology, 11(5), 316–326. doi:10.1038/nrmicro3009

Recommended Readings: Hidde Ploegh, Ph.D.

Friday Lecture Series

Host-pathogen Interactions: A Biochemist’s Perspective

Hidde Ploegh, Ph.D., professor of biology and member,

Whitehead Institute for Biomedical Research

March 28, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Carette, J. E., Guimaraes, C. P., Varadarajan, M., Park, A. S., Wuethrich, I., Godarova, A., . . . Brummelkamp, T. R. (2009). Haploid genetic screens in human cells identify host factors used by pathogens. Science, 326(5957), 1231-1235

Dougan, S. K., Hu, C. -. A., Paquet, M. -., Greenblatt, M. B., Kim, J., Lilley, B. N., . . . Ploegh, H. L. (2011). Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and Cellular Biology, 31(6), 1145-1159

Loureiro, J., & Ploegh, H. L. (2006). Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Advances in Immunology, 92, 225-305

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., . . . Sabatini, D. M. (2013). A CREB3-ARF4 signalling pathway mediates the response to golgi stress and susceptibility to pathogens. Nature Cell Biology, 15(12), 1473-1485

Tafesse, F. G., Sanyal, S., Ashour, J., Guimaraes, C. P., Hermansson, M., Somerharju, P., & Ploegh, H. L. (2013). Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6406-6411

Vyas, J. M., Van Der Veen, A. G., & Ploegh, H. L. (2008). The known unknowns of antigen processing and presentation. Nature Reviews Immunology, 8(8), 607-618

 

Recommended Readings: Martin Kampmann Ph.D. Monday, January 27

SPECIAL SEMINAR
Monday, January 27, 2014
4:00 p.m., Carson Family Auditorium

Martin Kampmann, Ph.D.
Postdoctoral Scholar
University of San Francisco

Toward a Systematic Understanding of the Mammalian Proteostasis Network and its Therapeutic Potential

Recommended Readings:

Empirical Papers

Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., … Weissman, J. S. (2013). A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell, 152(4), 909–922. doi:10.1016/j.cell.2013.01.030

Kampmann, M., Bassik, M. C., & Weissman, J. S. (2013). Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 110(25), E2317–2326. doi:10.1073/pnas.1307002110

Review Articles

Balch, W. E., Morimoto, R. I., Dillin, A., & Kelly, J. W. (2008). Adapting proteostasis for disease intervention. Science, 319(5865), 916–919. doi:10.1126/science.1141448

Hartl, F. U., Bracher, A., & Hayer-Hartl, M. (2011). Molecular chaperones in protein folding and proteostasis. Nature, 475(7356), 324–332. doi:10.1038/nature10317

Recommended Readings: Juleen R. Zierath, Ph.D.

Friday Lecture Series

Nicholson Lecture

Molecular Mechanisms for the Health-promoting Effects of Exercise: Why Muscle Matters!

Juleen R. Zierath, Ph.D., professor of physiology, department of molecular

medicine and surgery, Section for Integrative Physiology, Karolinska Institutet;

professor of integrative physiology and scientific director,

Novo Nordisk Foundation Center for Basic Metabolic Research,

Copenhagen University

October 25, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., . . . Zierath, J. R. (2012). Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metabolism, 15(3), 405-411

Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., . . . Auwerx, J. (2010). Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metabolism, 11(3), 213-219

Egan, B., Carson, B. P., Garcia-Roves, P. M., Chibalin, A. V., Sarsfield, F. M., Barron, N., . . . O’Gorman, D. J. (2010). Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor γ coactivator-1α mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. Journal of Physiology, 588(10), 1779-1790

Egan, B., O’Connor, P. L., Zierath, J. R., & O’Gorman, D. J. (2013). Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS ONE, 8(9)

Egan, B., & Zierath, J. R. (2013). Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metabolism, 17(2), 162-184

Russell, A. P., Lamon, S., Boon, H., Wada, S., Güller, I., Brown, E. L., . . . Akimoto, T. (2013). Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. Journal of Physiology, 591(18), 4637-4653

Szekeres, F., Chadt, A., Tom, R. Z., Deshmukh, A. S., Chibalin, A. V., Björnholm, M., . . . Zierath, J. R. (2012). The rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism. American Journal of Physiology – Endocrinology and Metabolism, 303(4), E524-E533

 

Recommended Readings: Hironori Funabiki, Ph.D.

Friday Lecture Series

Spindle or Envelope: Building Right on Chromosomes in Mitosis

Hironori Funabiki, Ph.D.,

associate professor, Laboratory of Chromosome and Cell Biology,

The Rockefeller University

October 4, 2013

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Carmena, M., Wheelock, M., Funabiki, H., & Earnshaw, W. C. (2012). The chromosomal passenger complex (CPC): From easy rider to the godfather of mitosis. Nature Reviews Molecular Cell Biology, 13(12), 789-803

Funabiki, H., & Murray, A. W. (2000). The xenopus chromokinesin xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell, 102(4), 411-424

Kelly, A. E., Ghenoiu, C., Xue, J. Z., Zierhut, C., Kimura, H., & Funabiki, H. (2010). Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase aurora B. Science, 330(6001), 235-239

Rivera, T., Ghenoiu, C., Rodríguez-Corsino, M., Mochida, S., Funabiki, H., & Losada, A. (2012). Xenopus shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO Journal, 31(6), 1467-1479

Sampath, S. C., Ohi, R., Leismann, O., Salic, A., Pozniakovski, A., & Funabiki, H. (2004). The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell, 118(2), 187-202

Tseng, B. S., Tan, L., Kapoor, T. M., & Funabiki, H. (2010). Dual detection of chromosomes and microtubules by the chromosomal passenger complex drives spindle assembly. Developmental Cell, 18(6), 903-91

 

Recommended Readings: Alexander Varshavsky, Ph.D.

Friday Lecture Series

William H. Stein Memorial Lecture

Recent Discoveries about the Ubiquitin System and the N-end Rule Pathway

Alexander Varshavsky, Ph.D.,

Howard and Gwen Laurie Smits Professor of Cell Biology,

California Institute of Technology

April 26, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Graciet, E., Walter, F., Maoiléidigh, D. Ó., Pollmann, S., Meyerowitz, E. M., Varshavsky, A., & Wellmer, F. (2009). The N-end rule pathway controls multiple functions during arabidopsis shoot and leaf development. Proceedings of the National Academy of Sciences of the United States of America, 106(32), 13618-13623

Hwang, C. -., Shemorry, A., Auerbach, D., & Varshavsky, A. (2010). The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases. Nature Cell Biology, 12(12), 1177-1185

Hwang, C. -., Shemorry, A., & Varshavsky, A. (2010). N-terminal acetylation of cellular proteins creates specific degradation signals. Science, 327(5968), 973-977

Hwang, C. -., Shemorry, A., & Varshavsky, A. (2009). Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase. Proceedings of the National Academy of Sciences of the United States of America, 106(7), 2142-2147

Varshavsky, A. (2006). The early history of the ubiquitin field. Protein Science, 15(3), 647-654

Varshavsky, A. (2011). The N-end rule pathway and regulation by proteolysis. Protein Science, 20(8), 1298-1345

Xia, Z., Webster, A., Du, F., Piatkov, K., Ghislain, M., & Varshavsky, A. (2008). Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway. Journal of Biological Chemistry, 283(35), 24011-24028

 

Recommended Readings: Maurice Swanson, Ph.D.

Friday Lecture Series

RNA-mediated Pathways to Disease

Maurice Swanson, Ph.D., associate director, Center for NeuroGenetics,

and professor of molecular genetics and microbiology,

University of Florida College of Medicine

 February 15, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Daughters, R. S., Tuttle, D. L., Gao, W., Ikeda, Y., Moseley, M. L., Ebner, T. J., . . . Ranum, L. P. W. (2009). RNA gain-of-function in spinocerebellar ataxia type 8. PLoS Genetics, 5(8)

Ho, T. H., Savkur, R. S., Poulos, M. G., Mancini, M. A., Swanson, M. S., & Cooper, T. A. (2005). Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy. Journal of Cell Science, 118(13), 2923-2933

Kanadia, R. N., Shin, J., Yuan, Y., Beattie, S. G., Wheeler, T. M., Thornton, C. A., & Swanson, M. S. (2006). Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 103(31), 11748-11753

Osborne, R. J., Lin, X., Welle, S., Sobczak, K., O’Rourke, J. R., Swanson, M. S., & Thornton, C. A. (2009). Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy. Human Molecular Genetics, 18(8), 1471-1481

Shin, J., Charizanis, K., & Swanson, M. S. (2009). Pathogenic RNAs in microsatellite expansion disease. Neuroscience Letters, 466(2), 99-102

Yuan, Y., Compton, S. A., Sobczak, K., Stenberg, M. G., Thornton, C. A., Griffith, J. D., & Swanson, M. S. (2007). Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs. Nucleic Acids Research, 35(16), 5474-5486