Recommended Readings: Winrich Freiwald, Ph.D., October 30th

Friday Lecture Series
Friday, October 30, 2015
3:45 p.m., Carson Family Auditorium (CRC)

Winrich Freiwald, Ph.D.
Assistant Professor,
Laboratory of Neural Systems,
The Rockefeller University

Face to Face: New Vistas on the Neural Mechanisms of Social Cognition

Recommended Readings

Empirical Articles

Fisher, C., & Freiwald, W. A. (2015). Contrasting specializations for facial motion within the macaque face-processing system. Current Biology, 25(2), 261-266. doi:10.1016/j.cub.2014.11.038.

Meyers, E. M., Borzello, M., Freiwald, W. A., & Tsao, D. (2015). Intelligent information loss: The coding of facial identity, head pose, and non-face information in the Macaque face patch system. The Journal of Neuroscience, 35(18), 7069-7081. doi:10.1523/JNEUROSCI.3086-14.2015.

Polosecki, P., Moeller, S., Schweers, N., Romanski, L. M., Tsao, D. Y., & Freiwald, W. A. (2013). Faces in motion: selectivity of macaque and human face processing areas for dynamic stimuli. The Journal of Neuroscience, 33(29), 11768-11773. doi: 10.1523/JNEUROSCI.5402-11.2013.

Schwiedrzik, C. M., Zarco, W., Everling, S., & Freiwald, W. A. (2015). Face patch resting state networks link face processing to social cognition. PLoS Biology, 13(9), e1002245. doi:10.1371/journal.pbio.1002245

Review Papers

Brecht, M., & Freiwald, W. A. (2012). The many facets of facial interactions in mammals. Current Opinion in Neurobiology, 22(2), 259-266. doi:10.1371/journal.pbio.1002245.

Recommended Readings: David Kingsley, Ph.D.

Friday Lecture Series

The Fairfield Osborn Memorial Lecture

Fishing for the Secrets of Vertebrate Evolution

David Kingsley, Ph.D., professor, developmental biology, Stanford University;

investigator, Howard Hughes Medical Institute

April 18, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

han, Y. F., Marks, M. E., Jones, F. C., Villarreal Jr., G., Shapiro, M. D., Brady, S. D., . . . Kingsley, D. M. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a pitxl enhancer. Science, 327(5963), 302-305

Haussler, D., O’Brien, S. J., Ryder, O. A., Keith Barker, F., Clamp, M., Crawford, A. J., . . . Turner, S. (2009). Genome 10K: A proposal to obtain whole-genome sequence for 10000 vertebrate species. Journal of Heredity, 100(6), 659-674

Jones, F. C., Grabherr, M. G., Chan, Y. F., Russell, P., Mauceli, E., Johnson, J., . . . Kingsley, D. M. (2012). The genomic basis of adaptive evolution in threespine sticklebacks. Nature, 484(7392), 55-61

Kingsley, D. M., Zhu, B., Osoegawa, K., De Jong, P. J., Schein, J., Marra, M., . . . Myers, R. (2004). New genomic tools for molecular studies of evolutionary change in threespine sticklebacks. Behaviour, 141(11-12), 1331-1344

Lowe, C. B., Kellis, M., Siepel, A., Raney, B. J., Clamp, M., Salama, S. R., . . . Haussler, D. (2011). Three periods of regulatory innovation during vertebrate evolution. Science, 333(6045), 1019-1024

Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006). Parallel genetic origins of pelvic reduction in vertebrates. Proceedings of the National Academy of Sciences of the United States of America, 103(37), 13753-13758


Recommended Readings: Wiley Prize in Biomedical Sciences

Friday Lecture Series

Wiley Prize in Biomedical Sciences

Deborah E. Wiley, chair, The Wiley Foundation, Welcome

Gunter Blobel, Ph.D., chair, Wiley Prize Jury, Award Presentation and Introduction of Award Lecture

William G. Kaelin, Jr., M.D., professor, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School; investigator, Howard Hughes Medical Institute, Lessons from von Hippel-Lindau Disease

Steven McKnight, Ph.D., professor and chairman, department of biochemistry, University of Texas Southwestern Medical Center, Hitting the Bullseye of HIF2a, the Kidney Cancer Oncoprotein

Peter J. Ratcliffe, M.D., professor and head, Nuffield Department of Medicine, University of Oxford, From Epo to Oxygen: Elucidation of Hypoxia Sensing in Animals

Gregg L. Semenza, M.D., Ph.D., professor and director, vascular program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Regulation of Oxygen Homeostasis by Hypoxia-inducible Factors

April 11, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Beckmann, R., Spahn, C. M. T., Eswar, N., Helmers, J., Penczek, P. A., Sali, A., . . . Blobel, G. (2001). Architecture of the protein-conducting channel associated with the translating 80S ribosome. Cell, 107(3), 361-372

Kaelin Jr., W. G., & McKnight, S. L. (2013). Influence of metabolism on epigenetics and disease. Cell, 153(1), 56-69

McKnight, S. L. (2010). On getting there from here. Science, 330(6009), 1338-1339

Ratcliffe, P. J. (2013). Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer. Journal of Physiology, 591(8), 2027-2042

Semenza, G. L. (2013). Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene, 32(35), 4057-4063



Recommended Readings: David Ginty, Ph.D.

Friday Lecture Series

The Sensory Neurons of Touch

David Ginty, Ph.D., Edward R. and Anne G. Lefler Professor,

department of neurobiology, Harvard Medical School;

investigator, Howard Hughes Medical Institute

April 4, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Abraira, V., & Ginty, D. (2013). The sensory neurons of touch. Neuron, 79(4), 618-639

Deppmann, C. D., Mihalas, S., Sharma, N., Lonze, B. E., Niebur, E., & Ginty, D. D. (2008). A model for neuronal competition during development. Science, 320(5874), 369-373

Li, L., Rutlin, M., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., . . . Ginty, D. D. (2011). The functional organization of cutaneous low-threshold mechanosensory neurons. Cell, 147(7), 1615-1627

Luo, W., Wickramasinghe, S. R., Savitt, J. M., Griffin, J. W., Dawson, T. M., & Ginty, D. D. (2007). A hierarchical NGF signaling cascade controls ret-dependent and ret-independent events during development of nonpeptidergic DRG neurons. Neuron, 54(5), 739-754

Riccio, A., Alvania, R. S., Lonze, B. E., Ramanan, N., Kim, T., Huang, Y., . . . Ginty, D. D. (2006). A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Molecular Cell, 21(2), 283-294

Wickramasinghe, S. R., Alvania, R. S., Ramanan, N., Wood, J. N., Mandai, K., & Ginty, D. D. (2008). Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron, 58(4), 532-545


Recommended Readings: Hidde Ploegh, Ph.D.

Friday Lecture Series

Host-pathogen Interactions: A Biochemist’s Perspective

Hidde Ploegh, Ph.D., professor of biology and member,

Whitehead Institute for Biomedical Research

March 28, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Carette, J. E., Guimaraes, C. P., Varadarajan, M., Park, A. S., Wuethrich, I., Godarova, A., . . . Brummelkamp, T. R. (2009). Haploid genetic screens in human cells identify host factors used by pathogens. Science, 326(5957), 1231-1235

Dougan, S. K., Hu, C. -. A., Paquet, M. -., Greenblatt, M. B., Kim, J., Lilley, B. N., . . . Ploegh, H. L. (2011). Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and Cellular Biology, 31(6), 1145-1159

Loureiro, J., & Ploegh, H. L. (2006). Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions. Advances in Immunology, 92, 225-305

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., . . . Sabatini, D. M. (2013). A CREB3-ARF4 signalling pathway mediates the response to golgi stress and susceptibility to pathogens. Nature Cell Biology, 15(12), 1473-1485

Tafesse, F. G., Sanyal, S., Ashour, J., Guimaraes, C. P., Hermansson, M., Somerharju, P., & Ploegh, H. L. (2013). Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6406-6411

Vyas, J. M., Van Der Veen, A. G., & Ploegh, H. L. (2008). The known unknowns of antigen processing and presentation. Nature Reviews Immunology, 8(8), 607-618


Recommended Readings: Diane Mathis, Ph.D.

Friday Lecture Series

The Ernst A.H. Friedheim Memorial Lecture

Aire, a Transcriptional Regulator Critical for Immunological Tolerance

Diane Mathis, Ph.D., professor, division of immunology,

department of microbiology and immunobiology, Harvard Medical School

March 21, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Abramson, J., Giraud, M., Benoist, C., & Mathis, D. (2010). Aire’s partners in the molecular control of immunological tolerance. Cell, 140(1), 123-135

Burzyn, D., Benoist, C., & Mathis, D. (2013). Regulatory T cells in nonlymphoid tissues. Nature Immunology, 14(10), 1007-1013

D’Alise, A. M., Ergun, A., Hill, J. A., Mathis, D., & Benoist, C. (2011). A cluster of coregulated genes determines TGF-β – induced regulatory T-cell (treg) dysfunction in NOD mice. Proceedings of the National Academy of Sciences of the United States of America, 108(21), 8737-8742

Fu, W., Ergun, A., Lu, T., Hill, J. A., Haxhinasto, S., Fassett, M. S., . . . Benoist, C. (2012). A multiply redundant genetic switch ‘locks in’ the transcriptional signature of regulatory T cells. Nature Immunology, 13(10), 972-980

Giraud, M., Yoshid, H., Abramson, J., Rahl, P. B., Young, R. A., Mathis, D., & Benoist, C. (2012). Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proceedings of the National Academy of Sciences of the United States of America, 109(2), 535-540

Koh, A. S., Kingston, R. E., Benoist, C., & Mathis, D. (2010). Global relevance of aire binding to hypomethylated lysine-4 of histone-3. Proceedings of the National Academy of Sciences of the United States of America, 107(29), 13016-13021

Yang, S., Bansal, K., Lopes, J., Benoist, C., & Mathis, D. (2013). Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proceedings of the National Academy of Sciences of the United States of America, 110(5), 1833-1838


Recommended Readings: Titia de Lange, Ph.D.

Friday Lecture Series

Breaking Bad: How Telomeres Hide from the DNA Damage Response

Titia de Lange, Ph.D., Leon Hess Professor, Head of the Laboratory of Cell Biology and Genetics, The Rockefeller University

February 28, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Davoli, T., Denchi, E. L., & de Lange, T. (2010). Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell, 141(1), 81-93

Hockemeyer, D., Sfeir, A. J., Shay, J. W., Wright, W. E., & De Lange, T. (2005). POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO Journal, 24(14), 2667-2678

Jacobs, J. J. L., & De Lange, T. (2005). p16INK4a as a second effector of the telomere damage pathway. Cell Cycle, 4(10), 1364-1368

Konishi, A., & De Lange, T. (2008). Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes and Development, 22(9), 1221-1230

Sfeir, A., & De Lange, T. (2012). Removal of shelterin reveals the telomere end-protection problem. Science, 336(6081), 593-597

Sfeir, A., Kabir, S., Van Overbeek, M., Celli, G. B., & De Lange, T. (2010). Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science, 327(5973), 1657-1661

Wu, P., Takai, H., & De Lange, T. (2012). Telomeric 3′ overhangs derive from resection by Exo1 and apollo and fill-in by POT1b-associated CST. Cell, 150(1), 39-52


Recommended Readings: Michael Strand, Ph.D.

Friday Lecture Series

Polydnaviruses: Viral Mutualists and Nature’s Genetic Engineers

Michael Strand, Ph.D., Regents Professor, department of entomology,

University of Georgia

February 21, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Beck, M. H., & Strand, M. R. (2007). A novel polydnavirus protein inhibits the insect prophenoloxidase activation pathway. Proceedings of the National Academy of Sciences of the United States of America, 104(49), 19267-19272

Burke, G. R., Thomas, S. A., Eum, J. H., & Strand, M. R. (2013). Mutualistic polydnaviruses share essential replication gene functions with pathogenic ancestors. PLoS Pathogens, 9(5)

Strand, M. R., & Burke, G. R. (2012). Polydnaviruses as symbionts and gene delivery systems. PLoS Pathogens, 8(7), 5

Thoetkiattikul, H., Beck, M. H., & Strand, M. R. (2005). Inhibitor κB-like proteins from a polydnavirus inhibit NF-κB activation and suppress the insect immune response. Proceedings of the National Academy of Sciences of the United States of America, 102(32), 11426-11431

Webb, B. A., Strand, M. R., Dickey, S. E., Beck, M. H., Hilgarth, R. S., Barney, W. E., . . . Witherell, R. A. (2006). Polydnavirus genomes reflect their dual roles as mutualists and pathogens. Virology, 347(1), 160-174


Recommended Readings: Ueli Schibler Ph.D. February 14

Friday Lecture Series
Friday, February 14, 2014
3:45 p.m., Caspary Auditorium

Ueli Schibler, PhD
University of Geneva
Department of Molecular Biology

The Mammalian Circadian Timing System: Communication Between Clocks

Recommended Readings:

Empirical Articles

Balsalobre, A., Brown, S.A., Marcacci, L., … Schibler, U. (2000). Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science, 289(5488), 2344–2347. doi:10.1126/science.289.5488.2344

Balsalobre, A., Damiola, F., & Schibler, U. (1998). A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell, 93(6), 929–937. doi:10.1016/S0092-8674(00)81199-X

Damiola, F., Le Minh, N., Preitner, N., … Schibler, U. (2000). Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes & Development, 14(23), 2950–2961. doi:10.1101/gad.183500

Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013). Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell, 152(3), 492–503. doi:10.1016/j.cell.2012.12.027

Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007). System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biology, 5(2), e34. doi:10.1371/journal.pbio.0050034

Review Papers

Dibner, C., Schibler, U., & Albrecht, U. (2010). The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annual Review of Physiology, 72, 517–549. doi:10.1146/annurev-physiol-021909-135821

Gachon, F., Nagoshi, E., Brown, S. a, Ripperger, J., & Schibler, U. (2004). The mammalian circadian timing system: from gene expression to physiology. Chromosoma, 113(3), 103–112. doi:10.1007/s00412-004-0296-2

Schibler, U., & Sassone-Corsi, P. (2002). A web of circadian pacemakers. Cell, 111(7), 919–922. doi:10.1016/S0092-8674(02)01225-4

Recommended Readings: Max Cooper, M.D.

Friday Lecture Series

How Did Our Adaptive Immune System Evolve?

Max Cooper, M.D., professor, Emory Vaccine Center and Emory Center for AIDS Research, Emory University School of Medicine

January 31, 2014

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Alder, M. N., Rogozin, I. B., Iyer, L. M., Glazko, G. V., Cooper, M. D., & Pancer, Z. (2005). Immunology: Diversity and function of adaptive immune receptors in a jawless vertebrate. Science, 310(5756), 1970-1973

Cooper, M. D. (2010). A life of adventure in immunobiology. Annual Review of Immunology 28, 11-19

Cooper, M. D., & Herrin, B. R. (2010). How did our complex immune system evolve? Nature Reviews Immunology, 10(1), 2-3

Guo, P., Hirano, M., Herrin, B. R., Li, J., Yu, C., Sadlonova, A., & Cooper, M. D. (2009). Dual nature of the adaptive immune system in lampreys. Nature, 459(7248), 796-801

Hirano, M., Das, S., Guo, P., & Cooper, M. D. (2011). The evolution of adaptive immunity in vertebrates. Advances in Immunology 109, pp. 125-157

Pancer, Z., & Cooper, M. D. (2006). The evolution of adaptive immunity. Annual Review of Immunology 24 , pp. 497-518