Recommended Readings: Beth Stevens, Ph.D. Friday May 4, 2018

Friday Lectures

Friday, May 4, 2018  3:45 p.m.

Caspary Auditorium

Beth Stevens Ph.D.

Associate Professor

Department of Neurology

Harvard Medical School – Boston Children’s Hospital

How the Immune System Sculpts Brain Circuitry

Recommended Readings:

Science News

Beth Stevens and Todd E. Golden. Deciphering neurodegeneration: Inflammation, immune response, and Alzheimer’s. (Webinar – February 7, 2018). Science

Empirical Articles

Shi, Qiaoqiao; Chowdhury, Saba; Ma, Rong; et al. (2017). Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. SCIENCE TRANSLATIONAL MEDICINE. 9 (392)

Hong, Soyon; Beja-Glasser, Victoria F.; Nfonoyim, Bianca M.; et al. (2016). Complement and microglia mediate early synapse loss in Alzheimer mouse models. SCIENCE. 352 (6286): 712-716

Vasek, Michael J.; Garber, Charise; Dorsey, Denise; et al. (2016). A complement-microglial axis drives synapse loss during virus-induced memory impairment. NATURE. 534 (7608): 538-+

Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; et al. (2016). Schizophrenia risk from complex variation of complement component 4. NATURE. 530 (7589): 177-+

Schafer, Dorothy P.; Lehrman, Emily K.; Heller, Christopher T.; et al. (2014). An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 88

Schafer, Dorothy P.; Lehrman, Emily K.; Kautzman, Amanda G.; et al. (2012). Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner. NEURON. 74 (4): 691-705

Review Paper

Salter, Michael W.; Stevens, Beth. (2017). Microglia emerge as central players in brain disease. NATURE MEDICINE. 23 (9): 1018-1027

Hong, Soyon; Dissing-Olesen, Lasse; Stevens, Beth. (2016). New insights on the role of microglia in synaptic pruning in health and disease. CURRENT OPINION IN NEUROBIOLOGY. 36: 128-134  

Bilimoria, Parizad M.; Stevens, Beth. (2015). Microglia function during brain development: New insights from animal models. BRAIN RESEARCH. 1617: 7-17  

Book Chapter

Stephan, Alexander H.; Barres, Ben A.; Stevens, Beth. (2012). The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease.  ANNUAL REVIEW OF NEUROSCIENCE. 35: 369-389

Recommended Readings: Michael Greenberg, Ph.D. Friday March 9th, 2018

Friday Lectures

Friday, March 9th, 2018  3:45 p.m.

Caspary Auditorium

Michael Greenberg, Ph.D.

Department Chair and Nathan Marsh Pusey Professor

Department of Neurobiology

Harvard Medical School

How Nature and Nurture Conspire to Control Brain Development and Function

Recommended Readings:

Empirical Articles

Kalish, Brian T.; Cheadle, Lucas; Hrvatin, Sinisa; et al. (2018). Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement. PNAS. 115 (5): E1051-E1060

Hrvatin, Sinisa; Hochbaum, Daniel R.; Nagy, M. Aurel; et al. (2018). Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. NATURE NEUROSCIENCE. 21 (1): 120-+

Gabel, Harrison W.; Kinde, Benyam; Stroud, Hume; et al. (2015). Disruption of DNA-methylation-dependent long gene repression in Rett syndrome. NATURE. 522 (7554): 89-U221

Malik, Athar N.; Vierbuchen, Thomas; Hemberg, Martin; et al. (2014). Genome-wide identification and characterization of functional neuronal activity-dependent enhancers. NATURE NEUROSCIENCE. 17 (10): 1330-1339

West, Anne E.; Greenberg, Michael E. (2011). Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 3 (6)

Greer, Paul L.; Hanayama, Rikinari; Bloodgood, Brenda L.; et al. (2010). The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc. CELL. 140 (5): 704-716

Review Papers

Hardingham, Giles E.; Pruunsild, Priit; Greenberg, Michael E.; et al. (2018). Lineage divergence of activity-driven transcription and evolution of cognitive ability. NATURE REVIEWS NEUROSCIENCE. 19 (1): 9-15

Ebert, Daniel H.; Greenberg, Michael E. (2013). Activity-dependent neuronal signalling and autism spectrum disorder. NATURE. 493 (7432): 327-337

Book Chapter

Flavell, Steven W.; Greenberg, Michael E. (2008). Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. ANNUAL REVIEW OF NEUROSCIENCE. 31: 563-590

 

Recommended Readings: Rachel Wilson, Ph.D. Friday December 15th, 2017

Friday Lectures

Friday, December 15, 2017  3:45 p.m.

Caspary Auditorium

Rachel Wilson, Ph.D.

Martin Family Professor

Department of Neurobiology

Harvard Medical School

Neural Correlates of Orienting Behaviors and Latent Action Biases

 

Recommended Readings:

Empirical Articles

Azevedo, Anthony W.; Wilson, Rachel I. (2017). Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons. NEURON. 96 (2): 446-+

Tobin, William F.; Wilson, Rachel I.; Lee, Wei-Chung Allen (2017). Wiring variations that enable and constrain neural computation in a sensory microcircuit. ELIFE. 6: e24838

Tuthill, John C.; Wilson, Rachel I. (2016). Parallel Transformation of Tactile Signals in Central Circuits of Drosophila. CELL. 164 (5): 1046-1059

Chang, Allison E. B.; Vaughan, Alex G.; Wilson, Rachel I. (2016). A Mechanosensory Circuit that Mixes Opponent Channels to Produce Selectivity for Complex Stimulus Features. NEURON. 92 (4): 888-901  

Jeanne, James M.; Wilson, Rachel I. (2015). Convergence, Divergence, and Reconvergence in a Feedforward Network Improves Neural Speed and Accuracy. NEURON. 88 (5)

Olsen, Shawn R.; Wilson, Rachel I. (2008). Lateral presynaptic inhibition mediates gain control in an olfactory circuit. NATURE. 452 (7190): 956-U3

Review Papers

Tuthill, John C.; Wilson, Rachel I. (2016). Mechanosensation and Adaptive Motor Control in Insects. CURRENT BIOLOGY. 26 (20): R1022-R1038

Olsen, Shawn R.; Wilson, Rachel I. (2008). Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. TRENDS IN NEUROSCIENCES. 31(10): 512-520

Book Chapter

Wilson, Rachel I. (2013). Early Olfactory Processing in Drosophila: Mechanisms and Principles. ANNUAL REVIEW OF NEUROSCIENCE. Book Series: Annual Review of Neuroscience. 36: 217-241

 

 

 

 

Recommended Readings: Leslie B. Vosshall, Ph.D. March 3, 2017

Friday Lectures

Friday, March 03, 2017   3:45 p.m.

Caspary Auditorium

Leslie B. Vosshall, Ph.D.

Robin Chemers Neustein Professor and Head,

Laboratory of Neurogenetics and Behavior,

The Rockefeller University

NEUROBIOLOGY OF THE WORLD’S MOST DANGEROUS ANIMAL

Recommended Readings:

Bezzina A. Malaria infection smells irresistible to mosquitoes. Cosmos. Feb 9 2017

Hurd H. Afraid of malaria? Get a chicken. BMC Blogs Network (blog). Aug 16 2016

Matthews, Benjamin J.; McBride, Carolyn S.; DeGennaro, Matthew; et al. (2016). The neurotranscriptome of the Aedes aegypti mosquito. BMC GENOMICS. 17(32)

Kistler, Kathryn E.; Vosshall, Leslie B.; Matthews, Benjamin J. (2015). Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti. CELL REPORTS. 11(1): 51-60

McBride, Carolyn S.; Baier, Felix; Omondi, Aman B.; et al. (2014). Evolution of mosquito preference for humans linked to an odorant receptor. NATURE. 515(7526): 222-U151

McMeniman, Conor J.; Corfas, Roman A.; Matthews, Benjamin J.; et al. (2014). Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans. CELL. 156(5): 1060-1071  

Takken, Willem; Verhulst, Niels O. (2013). Host Preferences of Blood-Feeding Mosquitoes.
ANNUAL REVIEW OF ENTOMOLOGY. 58: 433-453

Recommended Readings: Edward S. Boyden Ph.D. Friday February 17, 2017

Friday Lectures

Friday, February 17, 2017   3:45 p.m.

Caspary Auditorium

Edward S. Boyden,  Ph.D.

Associate Professor

MIT Media Lab

Optical Tools for Analyzing and Repairing

Complex Biological Systems

Recommended Readings:

Boyden, Edward S. (2015). Optogenetics and the future of neuroscience. NATURE NEUROSCIENCE. 18(12): 1862-1862

Chen, Fei; Tillberg, Paul W.; Boyden, Edward S. (2015). Expansion microscopy. SCIENCE. 347(6221): 543-548   

Madisen, Linda; Mao, Tianyi; Koch, Henner; et al. (2012). A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. NATURE NEUROSCIENCE. 15(5): 793-802

Bernstein, Jacob G.; Garrity, Paul A.; Boyden, Edward S.  (2012). Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits. CURRENT OPINION IN NEUROBIOLOGY.   22(1): 61-71

 

 

Recommended Readings: Marcello Magnasco Ph.D. Monday October 31, 2016

Monday Lectures

Monday October 31, 2016   3:45 p.m.

Caspary Auditorium

Marcello Magnasco, Ph.D.

Professor, Mathematical Physics

The Rockefeller University

Recommended Readings:

Janik VM, and Slater PJB.  Vocal Learning in Mammals.  Advances in the Study of Behavior,   26:59-99     1997    Request through Markus Library at librequest@rockefeller.edu

Reiss D, and McCowan B.  Spontaneous Vocal Mimicry and Production by Bottle-nosed Dolphins (Tursiops truncatus) – evidence for vocal learning.   Journal of Comparative Psychology   107(3):301-312    Sept  1997

McCowan B, Hanser SF, and Doyle LR.  Quantitative Tools for Comparing Animal Communication Systems: information theory applied to bottlenose dolphin whistle repertoires.  Animal Behavior.  57:409-419    Feb 1999

Janik VM.  Cetacean Vocal Learning and Communication.  Current Opinion in Neurobiology.  28:60-65    Oct 2014

Luis AR, Couchinho MN, and dos Santos ME.   Quantitative Analysis of Pulsed Signals Emitted by Wild Bottlenose Dolphins.  PLoS One   11(7):e0157781      July 2016

Gruden P, White PR, Oswald JN, Barkley Y, Cerchio S, Lammers M,and  Baumann-Pickering S.   Differences in Oscillatory Whistles Produced by Spinner (Stenella longirostris) and Pantropical Spotted (Stenella attenuata) Dolphins.   Marine Mammal Science  32:520-534    April 2016

Recommended Readings: Gaby Maimon, Ph.D., Sept 23, 2016

Friday Lecture Series

Head shot of Gaby Maimon

Gaby Maimon, Ph.D.

Assistant Professor
Laboratory of Integrative Brain Function

Quantitative Neural Computations in Behaving Drosophila

Recommended Readings:

Kim, A.J. et al. Cellular evidence for efference copy in Drosophila visuomotor processing. Nature Neuroscience. 18, 1247–1255 (2015).

Rien, D.; kern, R. and R. Kurtz.  Octopaminergic modulation of a fly visual motion-sensitive neuron during stimulation with naturalistic optic flow.  Frontiers in Bahavioral Neuroscience. 7, 155 (2013)

Maimon, G. Modulation of visual physiology by behavioral state in monkeys, mice, and flies. Current Opinions in Neurobiology. 21, 559–564 (2011).

Rosner, R. and A. K. Warzecha.  Relating neuronal to behavioral performance: variability of optomotor responses in the blowflyPLoS One.   6, 10:e26886 (2011)

Recommended Readings: Mary Hynes, Ph.D., May 23

Monday Lecture Series
Monday, May 23, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Mary Hynes, Ph.D.
Research Associate Professor,
Laboratory of Neural Specification and Development,
The Rockefeller University

Widespread Differential Expression of 3’ UTR and Cognate Coding Region Sequences in Neurons and Other Tissues

Recommended Readings:

Heiman, M., Kulicke, R., Fenster, R. J., Greengard, P., & Heintz, N. (2014). Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP). Nature Protocols, 9(6), 1282-1291. doi: 10.1038/nprot.2014.085.

Kocabas, A., Duarte, T., Kumar, S., & Hynes, M. A. (2015). Widespread differential expression of coding region and 3′ UTR sequences in neurons and other tissues. Neuron, 88(6), 1149-1156. doi: 10.1016/j.neuron.2015.10.048.

Recommended Readings: Mary Jeanne Kreek, M.D., May 2

Monday Lecture Series
Monday, May 2, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Mary Jeanne Kreek, M.D.
Senior Attending Physician,
The Rockefeller University Hospital
Patrick E. and Beatrice M. Haggerty Professor and Head,
Laboratory of the Biology of Addictive Diseases,
The Rockefeller University

50th Anniversary of First Research Paper on Methadone Maintenance Treatment: Update on Molecular, Neurobiological, Behavioral, and Genetic Research

Recommended Readings:

Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., … & Tischfield, J. A. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction. Proceedings of the National Academy of Sciences, 95(16), 9608-9613.

Butelman, E. R., Yuferov, V., & Kreek, M. J. (2012). κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends in Neurosciences, 35(10), 587-596. doi:10.1016/j.tins.2012.05.005.

Dole, V. P., Nyswander, M. E., & Kreek, M. J. (1966). Narcotic blockade. Archives of Internal Medicine, 118(4), 304-309. doi:10.1001/archinte.1966.00290160004002

Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8(11), 1450-1457. doi:10.1038/nn1583

Reed, B., Butelman, E. R., Yuferov, V., Randesi, M., & Kreek, M. J. (2014). Genetics of opiate addiction. Current Psychiatry Reports, 16(11), 1-12. doi:10.1007/s11920-014-0504-6.

Recommended Readings: Lindsay Schwarz, Ph.D., March 7

Special Seminar
Monday, March 7
4:00 p.m., Carson Family Auditorium (CRC)

Lindsay Schwarz, Ph.D.
Postdoctoral Fellow,
Department of Biology,
Stanford University

New Approaches for Uncovering Norepinephrine Circuit Organization and Function

Recommended Readings

Schwarz, L. A., & Luo, L. (2015). Organization of the locus coeruleus-norepinephrine system. Current Biology, 25(21), R1051-R1056. doi: 10.1016/j.cub.2015.09.039.

Schwarz, L. A., Miyamichi, K., Gao, X. J., Beier, K. T., Weissbourd, B., DeLoach, K. E., … & Luo, L. (2015). Viral-genetic tracing of the input-output organization of a central noradrenaline circuit. Nature, 524(7563), 88-92. doi: 10.1038/nature14600.