Raghavan AS, Hang HC . 2009 Seeing small molecules in action with bioorthogonal chemistry . 2009. DRUG DISCOVERY TODAY 14(3-4): 178-184 Request from Markus Library.
Doring O; Luthje S. 2001. Inhibition of trans-membrane hexacyanoferrate III reductase activity and proton secretion of maize (Zea mays L.) roots by thenoyltrifluoroacetone . PROTOPLASMA 217(1-3): 3-8 Request from Markus Library.
Howard Hughes Medical Institute, The Rockefeller University
May 10, 2010
3:45 p.m.-5:00 p.m. Welch Hall Level two
Recommended Articles:
Simon, C; Daniel, R. 2009. Achievements and new knowledge unraveled by metagenomic approaches. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 85(2): 265-276 Request from Markus Library.
McAlpine, J. B. 2009. Advances in the Understanding and Use of the Genomic Base of Microbial Secondary Metabolite Biosynthesis for the Discovery of New Natural Products. JOURNAL OF NATURAL PRODUCTS, 72(3, Sp. Iss. SI): 566-572 Request from Markus Library.
Brady S.F; Simmons L; Kim J.H. et al. 2009. Metagenomic approaches to natural products from free-living and symbiotic organisms . NATURAL PRODUCT REPORTS. 26(11): 1488-1503 Request from Markus Library.
Sharma P; Kumari, H; Kumar, M; Verna, M; KUmariu K; Malhotra, S; Kurana, J; Lal, R. 2008. From bacterial genomics to metagenomics: concept, tools and recent advances. Indian Journal of Microbiology. 48(2);173-194. Requesst from Markus Library.
A study published online March 4, 2010 in Science Expressreports the discovery that gut microbes may alter behavior and promote obesity and metabolic syndrome. HHMI investigator Rob Knight at the University of Colorado did the analysis that led to this conclusion. His study also showed that these bacteria may be transmissible between people.
Miyashita M, Miyagawa H. 2008. Plant pathogen recognition as a natural, original and simple model for chemogenomics: A brief overview of cell-based assays to screen for peptides acting as plant defense activators. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 11(8): 647-652 Request from Markus Library
Bustamante, J., S. Boisson-Dupuis, E. Jouanguy, C. Picard, A. Puel, L. Abel, and J. -L Casanova. 2008. Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases. Current opinion in immunology 20, (1): 39-48
Casanova, J. -L, and L. Abel. 2007. Primary immunodeficiencies: A field in its infancy. Science 317, (5838): 617-619
Quintana-Murci, L., A. Alcaïs, L. Abel, and J. -L Casanova. 2007. Immunology in natura: Clinical, epidemiological and evolutionary genetics of infectious diseases. Nature immunology 8, (11): 1165-1171
Von Bernuth, H., C. Picard, Z. Jin, R. Pankla, H. Xiao, C. -L Ku, M. Chrabieh, et al. 2008. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 321, (5889): 691-696
Research published August 27 in Chemistry & Biology demonstrates the viability of the NAD(P) biosynthesis pathway in bacterial pathogens as an antibiotic target for new broad spectrum antibiotics.
Magarvey NA, Fortin PD, Thomas PM, et al. 2008. Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. ACS CHEMICAL BIOLOGY 3(9):542-554
Roege KE, Kelly WL. 2009. Biosynthetic Origins of the Ionophore Antibiotic Indanomycin. ORGANIC LETTERS 11(2): 297-300
Bumpus SB, Kelleher NL.2008.Accessing natural product biosynthetic processes by mass spectrometry. CURRENT OPINION IN CHEMICAL BIOLOGY . 12(5): 475-482
Watanabe K.2008.Exploring the Biosynthesis of Natural Products and Their Inherent Suitability for the Rational Design of Desirable Compounds through Genetic Engineering. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72(10):2491-2506
Howard-Jones AR, Kruger RG, Lu W, et al.. 2007.Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(33):10082-+
La Clair JJ .2006.Cellular routines in the synthesis of cyclic peptide probes. TETRAHEDRON 62(22):5347-5354
Gruenewald S, Mootz HD, Stehmeier P, et al. 2004.In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 70(6): 3282-3291
New research demonstrates that cancer stem cells or “tumor-initiating cells,” when targeted with a reprogrammed herpes virus, can be prevented from turning malignant and re-initiating disease. The finding bolsters the theory that cancer harbors its own secret cache of stem cells that are resistant to conventional therapies and responsible for tumor re-emergence. This type of virus-against-cancer therapy may be the next generation of anti-cancer treatments. The study was published online Jan. 21 in the journal PLoS (Public Library of Science) One.
