Structural Biology Lecture Series
The Structural Basis of Decoding by the Ribosome
Dr. Venki Ramakrishnan
2009 Nobelist
Medical Research Council Laboratory of Molecular Biology
Wednesday September 28, 11 am, Caspary Hall
Recommended Readings:
Voorhees RM; Schmeing TM; Kelley AC; Ramakrishnan V. 2010. The mechanism for activation of GTP hydrolysis on the ribosome. Science 330:835-838.
Schmeing TM; Voorhees RM; Kelley AC; et al. 2009. The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA. Science 326(5953):688-694.
Gao Y-G; Selmer M; Dunham CM; Weixlbaumer A; Kelley AC; Ramakrishnan V. 2009. The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science 326:694-699.
Weixlbaumer A; Hong J; Neubauer C; Voorhees RM; Sabine P; Kelley AC; Ramakrishnan V. 2008. Insights into translational termination from the structure of RF2 bound to the ribosome. Science 322:953-956.
Selmer M; Duham CM; Murphy FV; Weixlbaumer A; Sabine P; Kelley AC; Weir JR; Ramakrishnan V. 2006. Science 313:1935-1942.
Petry S; Brodeson DE; Murphy FV; et al. 2005. Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon. Cell 123(7):1255-1266.
Ogle, JM; Murphy FV; Tarry MJ; et al. 2002. Selection of tRNA by the ribosome requires a transition from an open to a closed form. Cell 111(5):721-732.
Wimberly BT; Brodeson DE; Clemons WM; et al. Structure of the ribosomal subunit. 2000. NATURE 407(6802): 327-339.
Carter AP; Clemons WM; Broderson DE; et al. 2000. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. NATURE 407(6802):340-348.