Recommended Readings: Kivanç Birsoy, Ph.D. Monday May 20, 2019

Monday Lectures

Monday, May 20, 2019  4:00 p.m.

Carson Family Auditorium

Kivanç Birsoy, Ph.D.

Chapman Perelman Assistant Professor and Head

Laboratory of Metabolic Regulation and Genetics

The Rockefeller University

Metabolic Limitations of Cancer Cell Proliferation

  

Recommended Readings:

Science News

Oxygen-Starved Cancer Cells Languish without Aspartate. Jun 25, 2018. Genetic Engineering & Biotechnology News

Empirical Articles

Garcia-Bermudez, Javier; Baudrier, Lou; Bayraktar, Erol Can; et al. (2019). Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. NATURE. 567 (7746): 118-+

Phillips, Richard E.; Yang, Yanhong; Smith, Ryan C.; et al. (2019). Target identification reveals lanosterol synthase as a vulnerability in glioma. PNAS. 116 (16): 7957-7962

Bayraktar, Erol C.; Baudrier, Lou; Ozerdem, Ceren; et al. (2019). MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. PNAS. 116  (1) : 303-312

Garcia-Bermudez, Javier; Baudrier, Lou; La, Konnor; et al. (2018). Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. NATURE CELL BIOLOGY. 20 (7): 775-+

Peng, Xinxin; Chen, Zhongyuan; Farshidfar, Farshad; et al. (2018). Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. CELL REPORTS. 23 (1): 255-+

Reczek, Colleen R.; Birsoy, Kivanc; Kong, Hyewon; et al. (2017). A CRISPR screen identifies a pathway required for paraquat-induced cell death. NATURE CHEMICAL BIOLOGY. 13 (12): 1274-+

Chen, Walter W.; Freinkman, Elizaveta; Wang, Tim; et al. (2016). Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. CELL. 166 (5): 1324-+

Recommended Readings: George R. Stark, Ph.D. Friday May 10, 2019

Friday Lectures

Friday, May 10, 2019  3:45 p.m

Caspary Auditorium

George R. Stark Ph.D.

Distinguished Scientist

Department of Cancer Biology

Lerner Research Institute, Cleveland Clinic

 

Complex Regulation of Interferon-dependent Signaling in Cancer and Infectious Disease

 

Recommended Readings:

Science News

Promising New Combination Drug Therapy Treats Several Models of Lethal Lung Cancer. March 1, 2018. Cleveland Clinic

Empirical Articles

Banerjee, Shuvojit; Gusho, Elona; Gaughan, Christina; et al. (2019). OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug. PNAS. 116 (11): 5071-5076

Nan, Jing; Wang, Yuxin; Yang, Jinbo; et al. (2018). IRF9 and unphosphorylated STAT2 cooperate with NF-kappa B to drive IL6 expression. PNAS. 115 (15): 3906-3911

Stark, George R.; Cheon, HyeonJoo; Wang, Yuxin. (2018). Responses to Cytokines and Interferons that Depend upon JAKs and STATs. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 10 (1)

Wang, Yuxin; Nan, Jing; Willard, Belinda; et al. (2017). Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387. EMBO JOURNAL. 36 (2): 202-212

Cheon, HyeonJoo; Holvey-Bates, Elise G.; Schoggins, John W.; et al. (2013). IFN beta-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. EMBO JOURNAL. 32 (20): 2751-2763

Review Papers

Cheon, HyeonJoo; Borden, Ernest C.; Stark, George R. (2014). Interferons and Their Stimulated Genes in the Tumor Microenvironment. SEMINARS IN ONCOLOGY. 41 (2): 156-173

Stark, George R.; Darnell, James E., Jr. (2012). The JAK-STAT Pathway at Twenty. IMMUNITY. 36 (4): 503-514

Cheon, HyeonJoo; Yang, Jinbo; Stark, George R. (2011). The Functions of Signal Transducers and Activators of Transcriptions 1 and 3 as Cytokine-Inducible Proteins. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 31 (1): 33-40

Book Chapter

Lu, Tao; Stark, George R. (2015). Using Sequential Immunoprecipitation and Mass Spectrometry to Identify Methylation of NF-kappa B. NF-KAPPA B: METHODS AND PROTOCOLS. 1280: 383-393

 

Recommended Readings: Paul Bieniasz, Ph.D. Monday April 1, 2019

Monday Lectures

Monday, April 1, 2019  4:00 p.m.

Carson Family Auditorium

Paul Bieniasz, Ph.D.

Professor and Head

Laboratory of Retrovirology

The Rockefeller University

Virus and host discrimination of self and non-self RNA in HIV-1 infection

Recommended Readings:

Empirical Articles

Takata MA, Soll SJ, Emery A, Blanco-Melo D, Swanstrom R, Bieniasz PD. (2018). Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication. PLOS  PATHOGENS.14 (1)

Takata MA, Gonçalves-Carneiro D, Zang TM, Soll SJ, et al. (2017). CG dinucleotide suppression enables antiviral defence targeting non-self RNA. NATURE. 550 (7674): 124-127

Kessl, Jacques J.; Kutluay, Sebla B.; Townsend, Dana; et al. (2016). HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis. CELL. 166 (5): 1257

Review Paper

Bieniasz, Paul D.; Kutluay, Sebla B. (2018). CLIP-related methodologies and their application to retrovirology. RETROVIROLOGY. 15 (1)

Bieniasz, Paul D. (2012). An overview of intracellular interactions between immunodeficiency viruses and their hosts. AIDS. 26 (10): 1243-1254

Blanco-Melo, Daniel; Venkatesh, Siddarth; Bieniasz, Paul D. (2012). Intrinsic Cellular Defenses against Human Immunodeficiency Viruses. IMMUNITY. 37 (3): 399-411

Book Chapter

Bieniasz, Paul; Telesnitsky, Alice. (2018). Multiple, Switchable Protein: RNA Interactions Regulate Human Immunodeficiency Virus Type 1 Assembly. ANNUAL REVIEW OF VIROLOGY. 5: 165-183

Kutluay, Sebla B.; Bieniasz, Paul D. (2016). Analysis of HIV-1 Gag-RNA Interactions in Cells and Virions by CLIP-seq. HIV PROTOCOLS. 1354: 119-131

 

Recommended Readings: Howard C. Hang, Ph.D. Monday February 25, 2019

Monday Lectures

Monday, February 25, 2019  4:00 p.m.

Carson Family Auditorium

Howard C. Hang Ph.D.

Richard E. Salomon Family Associate Professor and Head

Laboratory of Chemical Biology and Microbial Pathogenesis

The Rockefeller University

Microbiota Modulation of Host Immunity, the SagA continues

Recommended Readings:

Empirical Articles

Liu W, Zhou Y, Peng T, Zhou P, Ding X, Li Z, Zhong H, Xu Y, Chen S, Hang HC, Shao F. (2018). Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. NATURE MICROBIOLOGY. 3 (9): 996-1009

Thinon, Emmanuelle; Fernandez, Joseph P.; Molina, Henrik; et al. (2018). Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. JOURNAL OF PROTEOME RESEARCH. 17 (5): 1907-1922

Rangan, Kavita J.; Pedicord, Virginia A.; Wang, Yen-Chih; et al. (2016). A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. SCIENCE. 353 (6306): 1434-1437

Pedicord, Virginia A.; Lockhart, Ainsley A. K.; Rangan, Kavita J.; et al. (2016). Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance. SCIENCE IMMUNOLOGY. 1 (3)    

Review Paper

Rangan, Kavita J.; Hang, Howard C. (2017). Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria. TRENDS IN BIOCHEMICAL SCIENCES. 42 (11): 887-898

Westcott, Nathan P.; Hang, Howard C. (2014). Chemical reporters for exploring ADP-ribosylation and AMPylation at the host-pathogen interface.  CURRENT OPINION IN CHEMICAL BIOLOGY. 23: 56-62

Grammel, Markus; Hang, Howard C. (2013). Chemical reporters for biological discovery. NATURE CHEMICAL BIOLOGY. 9 (8): 475-484

Recommended Readings: Tom Muir, Ph.D. Friday January 25, 2019

Friday Lectures

Friday, January 25, 2019  3:45 p.m

Caspary Auditorium

Tom Muir Ph.D.

Professor of Chemistry and Chair

Department of Chemistry

Princeton University

Painting Chromatin with Synthetic Protein Chemistry

 

Recommended Readings:

Empirical Articles

Nacev, B.A., Feng, L., Bagert, J.D. Lemiesz, A., et al. (2019). The expanding landscape of ‘oncohistone’ mutations in human cancers. NATURE, in press

Wojcik, Felix; Dann, Geoffrey P.; Beh, Leslie Y.; et al. (2018). Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. NATURE COMMUNICATIONS. 9

Lu, Chao; Jain, Siddhant U.; Hoelper, Dominik; et al. (2016). Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. SCIENCE. 352 (6287): 844-849

Nguyen, Uyen T. T.; Bittoval, Lenka; Mueller, Manuel M.; et al. (2014). Accelerated chromatin biochemistry using DNA-barcoded nucteosome libraries. NATURE METHODS. 11 (8): 834-840

Fierz, Beat; Kilic, Sinan; Hieb, Aaron R.; et al. (2012). Stability of Nucleosomes Containing Homogenously Ubiquitylated H2A and H2B Prepared Using Semisynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 134 (48): 19548-19551

Review Paper

David, Yael; Muir, Tom W. (2017). Emerging Chemistry Strategies for Engineering Native Chromatin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 139 (27): 9090-9096

Mueller, Manuel M.; Muir, Tom W. (2015). Histones: At the Crossroads of Peptide and Protein Chemistry. CHEMICAL REVIEWS. 115 (6): 2296-2349

Chatterjee, Champak; Muir, Tom W. (2010). Chemical Approaches for Studying Histone Modifications. JOURNAL OF BIOLOGICAL CHEMISTRY. 285 (15): 11045-11050

Book Chapter

Holt, Matthew; Muir, Tom (2015). Application of the Protein Semisynthesis Strategy to the Generation of Modified Chromatin. ANNUAL REVIEW OF BIOCHEMISTRY. 84: 265-290

McGinty, Robert K.; Chatterjee, Champak; Muir, Tom W. (2009). Semisynthesis of Ubiquitylated Proteins. METHODS IN ENZYMOLOGY: NON-NATURAL AMINO ACIDS. 462: 225-243

Recommended Readings: Howard C. Hang, Ph.D. Friday October 19, 2018

Friday Lectures

Friday, October 19, 2018  3:45 p.m.

Caspary Auditorium

Howard C. Hang Ph.D.

Richard E. Salomon Family Associate Professor and Head

Laboratory of Chemical Biology and Microbial Pathogenesis

The Rockefeller University

Chemical Dissection of Host-Microbe Interactions

Recommended Readings:

Empirical Articles

Liu W, Zhou Y, Peng T, Zhou P, Ding X, Li Z, Zhong H, Xu Y, Chen S, Hang HC, Shao F. (2018). Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. NATURE MICROBIOLOGY. 3 (9): 996-1009

Thinon, Emmanuelle; Fernandez, Joseph P.; Molina, Henrik; et al. (2018). Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. JOURNAL OF PROTEOME RESEARCH. 17 (5): 1907-1922

Westcott N, Fernandez JP, Molina H, Hang HC. (2017). Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress. NATURE CHEMICAL BIOLOGY. 13 (3): 302-308

Peng T, Hang HC. (2016). Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 138 (43): 14423-14433

Rangan, Kavita J.; Pedicord, Virginia A.; Wang, Yen-Chih; et al. (2016). A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. SCIENCE. 353 (6306): 1434-1437

Percher, Avital; Ramakrishnan, Srinivasan; Thinon, Emmanuelle; et al. (2016). Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation. PNAS. 113 (16): 4302-7

Review Paper

Peng, Tao; Thinon, Emmanuelle; Hang, Howard C. (2016). Proteomic analysis of fatty-acylated proteins. CURRENT OPINION IN CHEMICAL BIOLOGY. 30: 77-86

Westcott, Nathan P.; Hang, Howard C. (2014). Chemical reporters for exploring ADP-ribosylation and AMPylation at the host-pathogen interface.  CURRENT OPINION IN CHEMICAL BIOLOGY. 23: 56-62

Grammel, Markus; Hang, Howard C. (2013). Chemical reporters for biological discovery. NATURE CHEMICAL BIOLOGY. 9 (8): 475-484

Recommended Readings: Titia de Lange, Ph.D., Monday October 15, 2018

Monday Lectures

Monday, October 15, 2018  4:00 p.m.

Carson Family Auditorium

Titia de Lange, Ph.D.

Leon Hess Professor and Head

Laboratory of Cell Biology and Genetics

The Rockefeller University

 

Understanding DSB Repair: How Telomeres Gave Us a Break(through)

 

Recommended Readings:

Science News

Scientists discover a mechanism of drug resistance in breast and ovarian cancer. July 18, 2018. ScienceDaily 

Empirical Articles

Mirman Z, Lottersberger F, Takai H, Kibe T. et al. (2018). 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. NATURE. 560 (7716): 112-116

Gong, Yi; Handa, Naofumi; Kowalczykowski, Stephen C.; et al. (2017). PHF11 promotes DSB resection, ATR signaling, and HR. GENES AND DEVELOPMENT. 31 (1): 46-58

Doksani, Ylli; de Lange, Titia. (2016). Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining. CELL REPORTS. 17 (6)1646-1656

Lottersberger, Francisca; Karssemeijer, Roos Anna; Dimitrova, Nadya; et al. (2015). 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair. CELL. 163 (4):  880-893 

Doksani Y, de Lange T. (2014). The role of double-strand break repair pathways at functional and dysfunctional telomeres. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 6 (12)

Zimmermann, Michal; Lottersberger, Francisca; Buonomo, Sara B.; et al. (2013). 53BP1 Regulates DSB Repair Using Rif1 to Control 5 ‘ End Resection. SCIENCE. 339 (6120): 700-704

Lottersberger, Francisca; Bothmer, Anne; Robbiani, Davide F.; et al. (2013). Role of 53BP1 oligomerization in regulating double-strand break repair. PNAS. 110 (6): 2146-2151

Review Papers

Maciejowski, John; de lange, Titia. (2017). Telomeres in cancer: tumour suppression and genome instability. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 18 (3): 175-186

Zimmerman, Michal; de Lange, Titia. (2014). 53BP1: pro choice in DNA repair. TRENDS IN CELL BIOLOGY. 24 (2)108-117 

Recommended Readings: Michael W. Young, Ph.D., Monday October 8, 2018

Monday Lectures

Monday, October 8, 2018  4:00 p.m.

Carson Family Auditorium

Michael W. Young, Ph.D.

Richard and Jeanne Fisher Professor and Head

Laboratory of Genetics

The Rockefeller University

Genes Controlling Sleep and Circadian Rhythms

Recommended Readings:

Science News

Rosemary Braun. A Simple Blood Test Could Tell You the Time Inside Your Body. September 12, 2018. Discover Magazine

Empirical Articles

Young, Michael W. (2018). Time Travels: A 40-Year Journey from Drosophila’s Clock Mutants to Human Circadian Disorders (Nobel Lecture).  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57 (36): 11532-11539

Top, Deniz; Young, Michael W. (2018). Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 10 (7)

Lin, Changfan; Top, Deniz; Manahan, Craig C.; et al. (2018). Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction. PNAS. 115 (15): 3822-3827

Top, Deniz; O’Neil, Jenna L.; Merz, Gregory E.; et al. (2018). CK1/Doubletime activity delays transcription activation in the circadian clock. ELIFE. 7

Patke, Alina; Murphy, Patricia J.; Onat, Onur Emre; et al. (2017). Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. CELL.  169 (2): 203-215

Rogulja, Dragana; Young, Michael W. (2012). Control of Sleep by Cyclin A and Its Regulator. SCIENCE. 335 (6076): 1617-1621  

Zoltowski, Brian D.; Vaidya, Anand T.; Top, Deniz; et al. (2011). Structure of full-length Drosophila cryptochrome. NATURE. 480 (7377): 396-U156

Review Papers

Wijnen, Herman; Naef, Felix; Boothroyd, Catharine; et al. (2006). Control of daily transcript oscillations in Drosophila by light and the circadian clock. PLOS GENETICS. 2 (3): 326-343

Book Chapter

Axelrod, Sofia; Saez, Lino; Young, Michael W. (2015). Studying Circadian Rhythm and Sleep Using Genetic Screens in Drosophila. METHODS IN ENZIMOLOGY. 551: 3-27  

Crane, Brian R.; Young, Michael W. (2014). Interactive Features of Proteins Composing Eukaryotic Circadian Clocks. ANNUAL REVIEW OF BIOCHEMISTRY. 83: 191-219

Recommended Readings: Peter Reddien, Ph.D. Friday September 28, 2018

Friday Lectures

Friday, September 28, 2018  3:45 p.m.

Caspary Auditorium

Peter Reddien Ph.D.

Professor and Associate Department Head

Department of Biology

Massachusetts Institute of Technology

How Stem Cells and Positional Information Lead to Planarian Regeneration

Recommended Readings:

Science News

Lisa Girard. A blueprint for regeneration. March 15, 2018. MIT News

Empirical Articles

Fincher, Christopher T.; Wurtzel, Omri; de Hoog, Thom; et al. (2018). Cell type transcriptome atlas for the planarian Schmidtea mediterranea. SCIENCE.  360 (6391): 874-+

Atabay KD, LoCascio SA, de Hoog T, Reddien PW. (2018). Self-organization and progenitor targeting generate stable patterns in planarian regeneration. SCIENCE. 360 (6387):404-409

Scimone, M. Lucila; Cote, Lauren E.; Reddien, Peter W. (2017). Orthogonal muscle fibres have different instructive roles in planarian regeneration. NATURE. 551 (7682): 623-+  

Raz, Amelie A.; Srivastava, Mansi; Salvamoser, Ranja; et al. (2017). Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning. NATURE COMMUNCATIONS. 8

Wurtzel, Omri; Oderberg, Isaac M.; Reddien, Peter W. (2017). Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity. DEVELOPMENTAL CELL. 40 (5): 491-504  

Scimone, M. Lucila; Kravarik, Kellie M.; Lapan, Sylvain W.; et al. (2014). Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea. STEM CELLS REPORTS. 3 (2): 339-352

van Wolfswinkel, Josien C.; Wagner, Daniel E.; Reddien, Peter W. (2014). Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment. CELL STEM CELL. 15 (3): 326-339

Wagner, Daniel E.; Wang, Irving E.; Reddien, Peter W. (2011). Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration. SCIENCE. 332 (6031): 811-816  

Review Paper

Tanaka, Elly M.; Reddien, Peter W. (2011). The Cellular Basis for Animal Regeneration. DEVELOPMENTAL CELL. 21 (1): 172-185

Reddien, Peter W. (2011). Constitutive gene expression and the specification of tissue identity in adult planarian biology.  TRENDS IN GENETICS. 27 (7): 277-285  

Book Chapter

Wang IE, Wagner DE, Reddien PW. (2018). Clonal Analysis of Planarian Stem Cells by Subtotal Irradiation and Single-Cell Transplantation. Planarian Regeneration. 1774:479-495

Recommended Readings: David Pellman, M.D. Friday June 1, 2018

Friday Lectures

Friday, June 1, 2018  3:45 p.m.

Caspary Auditorium

David Pellman M.D.

Margaret M. Dyson Professor

Department of Cell Biology

Harvard Medical School

Mechanisms of Rapid Genome Evolution

Recommended Readings:

Science News

Dana-Farber Cancer Institute. Researchers identify origin of chromosomal oddity in some cancer cells. May 27, 2015. EurekAlert

Empirical Articles

Marteil, Gaelle; Guerrero, Adan; Vieira, Andre F.; et al. (2018). Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. NATURE COMMUNICATIONS. 9    

Zhang, Cheng-Zhong; Spektor, Alexander; Cornils, Hauke; et al. (2015). Chromothripsis from DNA damage in micronuclei. NATURE. 522 (7555): 179-+

Selmecki, Anna M.; Maruvka, Yosef E.; Richmond, Phillip A.; et al. (2015). Polyploidy can drive rapid adaptation in yeast. NATURE. 519 (7543): 349-+

Crasta, Karen; Ganem, Neil J.; Dagher, Regina; et al. (2012). DNA breaks and chromosome pulverization from errors in mitosis. NATURE. 482 (7383): 53-U70

Carter, Scott L.; Cibulskis, Kristian; Helman, Elena; et al. (2012). Absolute quantification of somatic DNA alterations in human cancer. NATURE BIOTECHNOLOGY. 30 (5): 413-+

Ganem, Neil J.; Godinho, Susana A.; Pellman, David. (2009). A mechanism linking extra centrosomes to chromosomal instability. NATURE. 460 (7252): 278-U146

Review Paper

Zhang, Cheng-Zhong; Leibowitz, Mitchell L.; Pellman, David. (2013). Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. GENES AND DEVELOPMENT. 27 (23): 2513-2530   

Gordon, David J.; Resio, Benjamin; Pellman, David. (2012). Causes and consequences of aneuploidy in cancer. NATURE REVIEWS GENETICS. 13 (3): 189-203

Book Chapter

Leibowitz, Mitchell L.; Zhang, Cheng-Zhong; Pellman, David. (2015). Chromothripsis: A New Mechanism for Rapid Karyotype Evolution. ANNUAL REVIEW OF GENETICS. 49: 183-211