Recommended Readings: Alexander Rudensky, Ph.D. Friday December 7, 2018

Friday Lectures

Friday, December 7, 2018  3:45 p.m

Caspary Auditorium

Alexander Rudensky Ph.D.

Tri-institutional Professor and Chair

Immunology Program

Memorial Sloan Kettering Cancer Center

Faces and Functions of Regulatory T Cells

 

Recommended Readings:

Empirical Articles

Fan, Xiying; Moltedo, Bruno; Mendoza, Alejandra; et al. (2018). CD49b defines functionally mature Treg cells that survey skin and vascular tissues. JOURNAL OF EXPERIMENTAL MEDICINE. 215 (11): 2796-2814  

Levine, Andrew G.; Medoza, Alejandra; Hemmers, Saskia; et al. (2017). Stability and function of regulatory T cells expressing the transcription factor T-bet. NATURE. 546 (7658): 421-+

Plitas, George; Konopacki, Catherine; Wu, Kenmin; et al. (2016). Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer. IMMUNITY. 45 (5): 1122-1134

Chinen, Takatoshi; Kannan, Arun K.; Levine, Andrew G.; et al. (2016). An essential role for the IL-2 receptor in T-reg cell function. NATURE IMMUNOLOGY. 17 (11): 1322-1333

By: Feng, Yongqiang; Arvey, Aaron; Chinen, Takatoshi; et al. (2014). Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus. CELL. 158 (4): 749-763

Zheng, Ye; Josefowicz, Steven; Chaudhry, Ashutosh; et al. (2010). Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. NATURE. 463 (7282): 808-U120  

Review Paper

Li, Ming O.; Rudensky, Alexander Y. (2016). T cell receptor signalling in the control of regulatory T cell differentiation and function. NATURE REVIEWS IMMUNOLOGY. 16 (4): 220-233

Fan, Xiying; Rudensky, Alexander Y. (2016). Hallmarks of Tissue-Resident Lymphocytes. CELL. 164 (6): 1198-1211

Rudensky, Alexander Y. (2011). Regulatory T cells and Foxp3. IMMUNOLOGICAL REVIEWS. 241: 260-268

Book Chapter

Josefowicz, Steven Z.; Lu, Li-Fan; Rudensky, Alexander Y. (2012). Regulatory T Cells: Mechanisms of Differentiation and Function. ANNUAL REVIEW OF IMMUNOLOGY. 30: 531-564

 

Recommended Readings: Ruslan Medzhitov, Ph.D. Friday January 12th, 2018

Friday Lectures

Friday, January 12, 2018  3:45 p.m.

Caspary Auditorium

Ruslan Medzhitov, Ph.D.

Sterling Professor

Department of Immunobiology

Yale University

Evolutionary Perspectives on Health and Disease

 

Recommended Readings:

Science News

Ziba Kashef. May 8, 2017. Study pinpoints key pathway in inflammation and aging. YaleNews

Empirical Articles

Ip, W. K. Eddie; Hoshi, Namiko; Shouval, Dror S.; et al. (2017). Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. SCIENCE. 356 (6337): 513-519

Kotas, Maya E.; Medzhitov, Ruslan (2015). Homeostasis, Inflammation, and Disease Susceptibility. CELL. (5): 816-827

Iwasaki, Akiko; Medzhitov, Ruslan (2015). Control of adaptive immunity by the innate immune system. NATURE IMMUNOLOGY. 16 (4): 343-353

Palm, Noah W.; Rosenstein, Rachel K.; Medzhitov, Ruslan (2012). Allergic host defences. NATURE. 484 (7395): 465-472

Review Papers

Medzhitov, Ruslan; Schneider, David S.; Soares, Miguel P. (2012). Disease Tolerance as a Defense Strategy. SCIENCE. 335 (6071): 936-941

Okin, Daniel; Medzhitov, Ruslan (2012). Evolution of Inflammatory Diseases. CURRENT BIOLOGY. 22 (17): R733-R740

Iwasaki, Akiko; Medzhitov, Ruslan (2010). Regulation of Adaptive Immunity by the Innate Immune System. SCIENCE. 327 (5963): 291-295

Recommended Readings: Erika Pearce, Ph.D., Wednesday September 20th, 2017

Special Seminar Series

Wednesday, September 20, 2017  4:00 p.m.

Carson Family Auditorium

Erika Pearce, Ph.D.

Senior Group Leader and Director

Department of Immunometabolism

Max Planck Institute of Immunobiology and Epigenetics

Mitochondrial Shapeshifting in the T Cell Response

Recommended Readings:

Erika Pearce. (2017). The Influence of Metabolism on the Function of T Cell Types. Latest Thinking.

Pan, Youdong; Tian, Tian; Park, Chang Ook; et al. (2017). Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. NATURE. 543 (7644): 252-+  

Man, Kevin; Kutyavin, Vassily I.; Chawla, Ajay. (2017). Tissue immunometabolism: development, physiology, and pathobiology. CELL METABOLISM. 25 (1): 11-26

Buck, Michael D.; O’Sullivan, David; Geltink, Ramon I. Klein; et al. (2016). Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. CELL. 66 (1): 63-76

Liesa, Marc; Shirihai, Orian S. (2016). Mitochondrial Networking in T Cell Memory. CELL. 166 (1): 9-10

Peng, Min; Yin, Na; Chhangawala, Sagar; et al. (2016). Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. SCIENCE. 354 (6311): 481-484

Newton, Ryan; Priyadharshini, Bhavana; Turka, Laurence A. (2016). Immunometabolism of regulatory T cells. NATURE IMMUNOLOGY. 17 (6): 618-625

Jang, Kyoung-Jin; Mano, Hiroto; Aoki, Koji; et al. (2015). Mitochondrial function provides instructive signals for activation-induced B-cell fates. NATURE COMMUNICATIONS. 6: 6750

Pearce, Erika L.; Pearce, Edward J. (2013). Metabolic Pathways in Immune Cell Activation and Quiescence. IMMUNITY. 38 (4): 633-643