Recommended Readings: Tom Maniatis, Ph.D., Friday October 6th, 2017

Friday Lectures

Friday, October 06, 2017  3:45 p.m.

Caspary Auditorium

Tom Maniatis, Ph.D.

Isidore S. Edelman Professor and Chair

Department of Biochemistry and Molecular Biophysics

Columbia University Medical Center

The Generation and Function of Protocadherin Cell Surface Diversity in Mammalian Neural Circuit Assembly

Recommended Readings:

Technology Networks Wrong Wiring Causes Depression. Apr 28, 2017

Rubinstein, Rotem; Goodman, Kerry Marie; Maniatis, Tom; et al. (2017). Structural origins of clustered protocadherin-mediated neuronal barcoding. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 69 (SI): 140-150. PLEASE REQUEST FROM MARKUS LIBRARY.

Chen, Weisheng V.; Nwakeze, Chiamaka L.; Denny, Christine A.; et al. (2017). Pcdh alpha c2 is required for axonal tiling and assembly of serotonergic circuitries in mice. SCIENCE. 356 (6336): 406-410

Mountoufaris, George; Chen, Weisheng V.; Hirabayashi, Yusuke; et al. (2017). Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. SCIENCE. 356 (6336): 411-413  

Goodman, Kerry Marie; Rubinstein, Rotem; Thu, Chan Aye; et al. (2016). gamma-Protocadherin structural diversity and functional implications. ELIFE. 5: e20930  

Chen, Weisheng V.; Maniatis, Tom (2013). Clustered protocadherins. DEVELOPMENT. 140 (16): 3297-3302

Lefebvre, Julie L.; Kostadinov, Dimitar; Chen, Weisheng V.; et al. (2012). Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. NATURE. 488 (7412): 517-+

Recommended Readings: Jack W. Szostak, Ph.D., Friday April 24, 2017

Friday Lectures

Friday, April 28, 2017   3:45 p.m.

Caspary Auditorium

Jack W. Szostak, Ph.D.

Professor of Genetics, Chemistry and Chemical Biology

Harvard University

Distinguished Investigator

Department of Molecular Biology and Center for Computational and Integrative Biology

Massachusetts General Hospital

The Surprising Chemistry of Nonenzymatic RNA Replication

Recommended Readings:

Li, Li; Prywes, Noam; Tam, Chun Pong; et al. (2017). Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 139(5): 1810-1813

Prywes, Noam; Blain, J. Craig; Del Frate, Francesca; et al. (2016). Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. ELIFE.  Article Number: e17756


Adamala, Katarzyna; Szostak, Jack W. (2013). Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells. SCIENCE. 342(6162): 1098-1100

Jack W Szostak. (2012). The eightfold path to non-enzymatic RNA replication. Journal of systems chemistry. 3(2) DOI: 10.1186/1759-2208-3-2

Wochner, Aniela; Attwater, James; Coulson, Alan; et al. (2011). Ribozyme-Catalyzed Transcription of an Active Ribozyme. SCIENCE. 332(6026): 209-212