Recommended Readings: Mandë Holford, Ph.D., Thursday April 25th, 2019

Special Seminar Series

Thursday, April 25, 2019  4:00 p.m.

Carson Family Auditorium

Mandë Holford, Ph.D.

Associate Professor

Department of Chemistry and Biology

The City University of New York – Hunter College & Graduate Center

 

 

The Transformative Power of Venom in Evolution and Biomedical Applications

Recommended Readings:

Science News

Emily Driscoll and Luke Groskin. (2017, Nov 2). Breakthrough: The Killer Snail Chemist. Science Friday

Empirical Articles

Eriksson, Anders; Anand, Prachi; Gorson, Juliette; et al. (2018). Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity. SCIENTIFIC REPORTS. 8

Leffler, Abba E.; Kuryatov, Alexander; Zebroski, Henry A.; et al. (2017). Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. PNAS. 114 (38): E8100-E8109

Kelly, Patrick; Anand, Prachi; Uvaydov, Alexander; et al. (2015). Developing a Dissociative Nanocontainer for Peptide Drug Delivery. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 12 (10): 12543-12555

Gorson, Juliette; Ramrattan, Girish; Verdes, Aida; et al. (2015). Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails. GENOME BIOLOGY AND EVOLUTION. 7 (6): 1761-1778

Anand, Prachi; Grigoryan, Alexandre; Bhuiyan, Mohammed H.; et al. (2014). Sample Limited Characterization of a Novel Disulfide-Rich Venom Peptide Toxin from Terebrid Marine Snail Terebra variegate. PLOS ONE. 9 (4)

Review Papers

Napolitano, Tanya; Holford, Mande. (2018). Breakthroughs in Venom Peptide Screening Methods to Advance Future Drug Discovery. PROTEIN AND PEPTIDE LETTERS. 25 (12): 1137-1148. PLEASE REQUEST FROM MARKUS LIBRARY.

Verdes, Aida; Anand, Prachi; Gorson, Juliette; et al. (2016). From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins. TOXINS. 8 (4)

Book Chapters

Verdes, Aida; Holford, Mande. (2018). Beach to Bench to Bedside: Marine Invertebrate Biochemical Adaptations and Their Applications in Biotechnology and Biomedicine. Marine Organisms as Model Systems in Biology and Medicine. RESULTS AND PROBLEMS IN CELL DIFFERENTIATION Book Series. 65. PLEASE REQUEST FROM MARKUS LIBRARY.

Fry, Bryan G.; Koludarov, Ivan; Jackson, Timothy N. W.; et al. (2015). Seeing the Woods for the Trees: Understanding Venom Evolution as a Guide for Biodiscovery. VENOMS TO DRUGS: VENOM AS A SOURCE FOR THE DEVELOPMENT OF HUMAN THERAPEUTICS. 42: 1-36. PLEASE REQUEST FROM MARKUS LIBRARY.

Recommended Readings: Christopher Chang, Ph.D. Wednesday March 6, 2019

Special Seminar Series

Wednesday, March 6, 2019  4:00 p.m.

Carson Family Auditorium

Christopher Chang, Ph.D.

Chair Professor

Department of Chemistry and Molecular and Cell Biology

University of California, Berkeley

Deciphering Transition Metal Signaling with Activity-Based Sensing

 

Recommended Readings:

Empirical Articles

Su TA, Shihadih DS, Cao W, Detomasi TC, Heffern MC, Jia S, Stahl A, Chang CJ. (2018). A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 140 (42): 13764–13774

Xiao, T.; Ackerman, C. M.; Carroll, E. C.; Jia, S.; et al. (2018). Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. NATURE CHEMICAL BIOLOGY. 14: 655-663

Smith, P. T.; Benke, B. P.; Cao, Z.; Kim, et al. (2018). Iron Porphyrins Embedded into a Supramolecular Porous Organic Cage for Electrochemical CO2 Reduction in Water. ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 57: 9684-9688

Aron, Allegra T.; Loehr, Morten O.; Bogena, Jana; et al. (2016). An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 138 (43): 14338-14346

Dodani, Sheel C.; Firl, Alana; Chan, Jefferson; et al. (2014). Copper is an endogenous modulator of neural circuit spontaneous activity. PNAS. 11 (46): 16280-16285

Dodani, Sheel C.; Domaille, Dylan W.; Nam, Christine I.; et al. (2011). Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy. PNAS. 108 (15): 5980-5985

Review Papers

Chang CJ. (2017). Bioinorganic Life and Neural Activity: Toward a Chemistry of Consciousness? ACCOUNTS OF CHEMICAL RESEARCH. 50 (3): 535-538

Ackerman, Cheri M.; Lee, Sumin; Chang, Christopher J. (2017). Analytical Methods for Imaging Metals in Biology: From Transition Metal Metabolism to Transition Metal Signaling. ANALYTICAL CHEMISTRY. 89 (1): 22-41

Cotruvo, Joseph A., Jr.; Aron, Allegra T.; Ramos-Torres, Karla M. et al. (2015). Synthetic fluorescent probes for studying copper in biological systems. CHEMICAL SOCIETY REVIEWS. 44 (13): 4400-4414

 

Recommended Readings: Tom Muir, Ph.D. Friday January 25, 2019

Friday Lectures

Friday, January 25, 2019  3:45 p.m

Caspary Auditorium

Tom Muir Ph.D.

Professor of Chemistry and Chair

Department of Chemistry

Princeton University

Painting Chromatin with Synthetic Protein Chemistry

 

Recommended Readings:

Empirical Articles

Nacev, B.A., Feng, L., Bagert, J.D. Lemiesz, A., et al. (2019). The expanding landscape of ‘oncohistone’ mutations in human cancers. NATURE, in press

Wojcik, Felix; Dann, Geoffrey P.; Beh, Leslie Y.; et al. (2018). Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. NATURE COMMUNICATIONS. 9

Lu, Chao; Jain, Siddhant U.; Hoelper, Dominik; et al. (2016). Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. SCIENCE. 352 (6287): 844-849

Nguyen, Uyen T. T.; Bittoval, Lenka; Mueller, Manuel M.; et al. (2014). Accelerated chromatin biochemistry using DNA-barcoded nucteosome libraries. NATURE METHODS. 11 (8): 834-840

Fierz, Beat; Kilic, Sinan; Hieb, Aaron R.; et al. (2012). Stability of Nucleosomes Containing Homogenously Ubiquitylated H2A and H2B Prepared Using Semisynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 134 (48): 19548-19551

Review Paper

David, Yael; Muir, Tom W. (2017). Emerging Chemistry Strategies for Engineering Native Chromatin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 139 (27): 9090-9096

Mueller, Manuel M.; Muir, Tom W. (2015). Histones: At the Crossroads of Peptide and Protein Chemistry. CHEMICAL REVIEWS. 115 (6): 2296-2349

Chatterjee, Champak; Muir, Tom W. (2010). Chemical Approaches for Studying Histone Modifications. JOURNAL OF BIOLOGICAL CHEMISTRY. 285 (15): 11045-11050

Book Chapter

Holt, Matthew; Muir, Tom (2015). Application of the Protein Semisynthesis Strategy to the Generation of Modified Chromatin. ANNUAL REVIEW OF BIOCHEMISTRY. 84: 265-290

McGinty, Robert K.; Chatterjee, Champak; Muir, Tom W. (2009). Semisynthesis of Ubiquitylated Proteins. METHODS IN ENZYMOLOGY: NON-NATURAL AMINO ACIDS. 462: 225-243

Recommended Readings: Jack W. Szostak, Ph.D., Friday April 24, 2017

Friday Lectures

Friday, April 28, 2017   3:45 p.m.

Caspary Auditorium

Jack W. Szostak, Ph.D.

Professor of Genetics, Chemistry and Chemical Biology

Harvard University

Distinguished Investigator

Department of Molecular Biology and Center for Computational and Integrative Biology

Massachusetts General Hospital

The Surprising Chemistry of Nonenzymatic RNA Replication

Recommended Readings:

https://pandasthumb.org/archives/2013/12/new-szostak-pro.html

Li, Li; Prywes, Noam; Tam, Chun Pong; et al. (2017). Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 139(5): 1810-1813

Prywes, Noam; Blain, J. Craig; Del Frate, Francesca; et al. (2016). Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides. ELIFE.  Article Number: e17756

Szostak, Jack W. (2016). ON THE ORIGIN OF LIFE. MEDICINA-BUENOS AIRES. 76(4): 199-203. PLEASE REQUEST FROM MARKUS LIBRARY

Adamala, Katarzyna; Szostak, Jack W. (2013). Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells. SCIENCE. 342(6162): 1098-1100

Jack W Szostak. (2012). The eightfold path to non-enzymatic RNA replication. Journal of systems chemistry. 3(2) DOI: 10.1186/1759-2208-3-2

Wochner, Aniela; Attwater, James; Coulson, Alan; et al. (2011). Ribozyme-Catalyzed Transcription of an Active Ribozyme. SCIENCE. 332(6026): 209-212