Recommended Readings: Anja Groth, Ph.D., Friday October 13th, 2017

Friday Lectures

Friday, October 13, 2017  3:45 p.m.

Caspary Auditorium

Anja Groth, Ph.D.

Professor and Group Leader

Biotech Research and Innovation Centre (BRIC)

 University of Copenhagen

Chromatin Replication and Epigenome Maintenance

 

Recommended Readings:

Hammond, Colin M.; Stromme, Caroline B.; Huang, Hongda; et al. (2017). Histone chaperone networks shaping chromatin function. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 18 (3): 141-158

Saredi, Giulia; Huang, Hongda; Hammond, Colin M.; et al. (2016). H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. NATURE. 534 (7609): 714-+   

Alabert, Constance; Barth, Teresa K.; Reveron-Gomez, Nazaret; et al. (2015). Two distinct modes for propagation of histone PTMs across the cell cycle. GENES & DEVELOPMENT 29 (6): 585-590

Huang, Hongda; Stromme, Caroline B.; Saredi, Giulia; et al. (2015). A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 22 (8): 618-626

Alabert, Constance; Bukowski-Wills, Jimi-Carlo; Lee, Sung-Bau; et al. (2014). Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.  NATURE CELL BIOLOGY. 16 (3): 281-+

Alabert, Constance; Groth, Anja (2012). Chromatin replication and epigenome maintenance. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 13 (3): 153-167

 

 

Recommended Readings: Erika Pearce, Ph.D., Wednesday September 20th, 2017

Special Seminar Series

Wednesday, September 20, 2017  4:00 p.m.

Carson Family Auditorium

Erika Pearce, Ph.D.

Senior Group Leader and Director

Department of Immunometabolism

Max Planck Institute of Immunobiology and Epigenetics

Mitochondrial Shapeshifting in the T Cell Response

Recommended Readings:

Erika Pearce. (2017). The Influence of Metabolism on the Function of T Cell Types. Latest Thinking.

Pan, Youdong; Tian, Tian; Park, Chang Ook; et al. (2017). Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. NATURE. 543 (7644): 252-+  

Man, Kevin; Kutyavin, Vassily I.; Chawla, Ajay. (2017). Tissue immunometabolism: development, physiology, and pathobiology. CELL METABOLISM. 25 (1): 11-26

Buck, Michael D.; O’Sullivan, David; Geltink, Ramon I. Klein; et al. (2016). Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. CELL. 66 (1): 63-76

Liesa, Marc; Shirihai, Orian S. (2016). Mitochondrial Networking in T Cell Memory. CELL. 166 (1): 9-10

Peng, Min; Yin, Na; Chhangawala, Sagar; et al. (2016). Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. SCIENCE. 354 (6311): 481-484

Newton, Ryan; Priyadharshini, Bhavana; Turka, Laurence A. (2016). Immunometabolism of regulatory T cells. NATURE IMMUNOLOGY. 17 (6): 618-625

Jang, Kyoung-Jin; Mano, Hiroto; Aoki, Koji; et al. (2015). Mitochondrial function provides instructive signals for activation-induced B-cell fates. NATURE COMMUNICATIONS. 6: 6750

Pearce, Erika L.; Pearce, Edward J. (2013). Metabolic Pathways in Immune Cell Activation and Quiescence. IMMUNITY. 38 (4): 633-643 

 

Recommended Readings: Kenneth Zaret, Ph.D., Friday May 26th, 2017

Friday Lectures

Friday, May 26, 2017  3:45 p.m.

Caspary Auditorium

Kenneth Zaret, Ph.D.

Joseph Leidy Professor, Department of Cell and Developmental Biology

Director, Institute for Regenerative Medicine

Perelman School of Medicine, University of Pennsylvania

Overcoming Chromatin Barriers to Control Cell Fate

Recommended Readings:

Zaret, Kenneth S.; Lerner, Jonathan; Iwafuchi-Doi, Makiko (2016). Chromatin Scanning by Dynamic Binding of Pioneer Factors. MOLECULAR CELL. 62 (5): 665-667

Zaret, Kenneth S.; Mango, Susan E. (2016). Pioneer transcription factors, chromatin dynamics, and cell fate control. CURRENT OPINION IN GENETICS & DEVELOPMENT. 37: 76-81

Iwafuchi-Doi, Makiko; Donahue, Greg; Kakumanu, Akshay; et al. (2016). The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation. MOLECULAR CELL. 62(1): 79-91

Soufi, Abdenour; Garcia, Meilin Fernandez; Jaroszewicz, Artur; et al. (2015). Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming. CELL. 161(3): 555-568

Zaret, Kenneth S.; Carroll, Jason S. (2011). Pioneer transcription factors: establishing competence for gene expression. GENES & DEVELOPMENT. 25 (21): 2227-2241

 
 

Recommended Readings: Edith Heard, Ph.D., Friday, April 21, 2017

Friday Lectures

Friday, April 21, 2017   3:45 p.m.

Caspary Auditorium

Edith Heard, Ph.D.

Professor and Chair, Epigenetics and Cellular Memory, Collège de France

Director, Department of Genetics and Developmental Biology

Institut Curie

The Epigenetic Dynamics of X-chromosome Inactivation: Fine-tuning Gene Dosage during Development

Recommended Readings:

https://www.sciencedaily.com/releases/2017/04/170417114752.htm

da Rocha, Simao T.; Heard, Edith (2017). Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 24(3): 197-204

Borensztein, Maud; Syx, Laurene; Ancelin, Katia; et al. (2017). Xist-dependent imprinted X inactivation and the early developmental consequences of its failure. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 24(3): 226-+

Giorgetti, Luca; Lajoie, Bryan R.; Carter, Ava C.; et al. (2016). Structural organization of the inactive X chromosome in the mouse. NATURE. 535(7613): 575-+

Wu, Hao; Luo, Junjie; Yu, Huimin; et al. (2014). Cellular Resolution Maps of X Chromosome Inactivation: Implications for Neural Development, Function, and Disease. NEURON. 81(1): 103-119

Gendrel, Anne-Valerie; Heard, Edith (2014). Noncoding RNAs and Epigenetic Mechanisms During X-Chromosome Inactivation.  ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 30: 561-580

Nora, Elphege P.; Lajoie, Bryan R.; Schulz, Edda G.; et al. (2012). Spatial partitioning of the regulatory landscape of the X-inactivation centre. NATURE. 485(7398): 381-385