Recommended Readings: Kenneth Zaret, Ph.D., Friday May 26th, 2017

Friday Lectures

Friday, May 26, 2017  3:45 p.m.

Caspary Auditorium

Kenneth Zaret, Ph.D.

Joseph Leidy Professor, Department of Cell and Developmental Biology

Director, Institute for Regenerative Medicine

Perelman School of Medicine, University of Pennsylvania

Overcoming Chromatin Barriers to Control Cell Fate

Recommended Readings:

Zaret, Kenneth S.; Lerner, Jonathan; Iwafuchi-Doi, Makiko (2016). Chromatin Scanning by Dynamic Binding of Pioneer Factors. MOLECULAR CELL. 62 (5): 665-667

Zaret, Kenneth S.; Mango, Susan E. (2016). Pioneer transcription factors, chromatin dynamics, and cell fate control. CURRENT OPINION IN GENETICS & DEVELOPMENT. 37: 76-81

Iwafuchi-Doi, Makiko; Donahue, Greg; Kakumanu, Akshay; et al. (2016). The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation. MOLECULAR CELL. 62(1): 79-91

Soufi, Abdenour; Garcia, Meilin Fernandez; Jaroszewicz, Artur; et al. (2015). Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming. CELL. 161(3): 555-568

Zaret, Kenneth S.; Carroll, Jason S. (2011). Pioneer transcription factors: establishing competence for gene expression. GENES & DEVELOPMENT. 25 (21): 2227-2241


Recommended Readings: Edith Heard, Ph.D., Friday, April 21, 2017

Friday Lectures

Friday, April 21, 2017   3:45 p.m.

Caspary Auditorium

Edith Heard, Ph.D.

Professor and Chair, Epigenetics and Cellular Memory, Collège de France

Director, Department of Genetics and Developmental Biology

Institut Curie

The Epigenetic Dynamics of X-chromosome Inactivation: Fine-tuning Gene Dosage during Development

Recommended Readings:

da Rocha, Simao T.; Heard, Edith (2017). Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 24(3): 197-204

Borensztein, Maud; Syx, Laurene; Ancelin, Katia; et al. (2017). Xist-dependent imprinted X inactivation and the early developmental consequences of its failure. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 24(3): 226-+

Giorgetti, Luca; Lajoie, Bryan R.; Carter, Ava C.; et al. (2016). Structural organization of the inactive X chromosome in the mouse. NATURE. 535(7613): 575-+

Wu, Hao; Luo, Junjie; Yu, Huimin; et al. (2014). Cellular Resolution Maps of X Chromosome Inactivation: Implications for Neural Development, Function, and Disease. NEURON. 81(1): 103-119

Gendrel, Anne-Valerie; Heard, Edith (2014). Noncoding RNAs and Epigenetic Mechanisms During X-Chromosome Inactivation.  ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 30: 561-580

Nora, Elphege P.; Lajoie, Bryan R.; Schulz, Edda G.; et al. (2012). Spatial partitioning of the regulatory landscape of the X-inactivation centre. NATURE. 485(7398): 381-385