Recommended Readings: Gaby Maimon, Ph.D., Sept 23, 2016

Friday Lecture Series

Head shot of Gaby Maimon

Gaby Maimon, Ph.D.

Assistant Professor
Laboratory of Integrative Brain Function

Quantitative Neural Computations in Behaving Drosophila

Recommended Readings:

Kim, A.J. et al. Cellular evidence for efference copy in Drosophila visuomotor processing. Nature Neuroscience. 18, 1247–1255 (2015).

Rien, D.; kern, R. and R. Kurtz.  Octopaminergic modulation of a fly visual motion-sensitive neuron during stimulation with naturalistic optic flow.  Frontiers in Bahavioral Neuroscience. 7, 155 (2013)

Maimon, G. Modulation of visual physiology by behavioral state in monkeys, mice, and flies. Current Opinions in Neurobiology. 21, 559–564 (2011).

Rosner, R. and A. K. Warzecha.  Relating neuronal to behavioral performance: variability of optomotor responses in the blowflyPLoS One.   6, 10:e26886 (2011)

Recommended Readings: Mary Jeanne Kreek, M.D., May 2

Monday Lecture Series
Monday, May 2, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Mary Jeanne Kreek, M.D.
Senior Attending Physician,
The Rockefeller University Hospital
Patrick E. and Beatrice M. Haggerty Professor and Head,
Laboratory of the Biology of Addictive Diseases,
The Rockefeller University

50th Anniversary of First Research Paper on Methadone Maintenance Treatment: Update on Molecular, Neurobiological, Behavioral, and Genetic Research

Recommended Readings:

Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., … & Tischfield, J. A. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction. Proceedings of the National Academy of Sciences, 95(16), 9608-9613.

Butelman, E. R., Yuferov, V., & Kreek, M. J. (2012). κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends in Neurosciences, 35(10), 587-596. doi:10.1016/j.tins.2012.05.005.

Dole, V. P., Nyswander, M. E., & Kreek, M. J. (1966). Narcotic blockade. Archives of Internal Medicine, 118(4), 304-309. doi:10.1001/archinte.1966.00290160004002

Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8(11), 1450-1457. doi:10.1038/nn1583

Reed, B., Butelman, E. R., Yuferov, V., Randesi, M., & Kreek, M. J. (2014). Genetics of opiate addiction. Current Psychiatry Reports, 16(11), 1-12. doi:10.1007/s11920-014-0504-6.

Recommended Readings: Lindsay Schwarz, Ph.D., March 7

Special Seminar
Monday, March 7
4:00 p.m., Carson Family Auditorium (CRC)

Lindsay Schwarz, Ph.D.
Postdoctoral Fellow,
Department of Biology,
Stanford University

New Approaches for Uncovering Norepinephrine Circuit Organization and Function

Recommended Readings

Schwarz, L. A., & Luo, L. (2015). Organization of the locus coeruleus-norepinephrine system. Current Biology, 25(21), R1051-R1056. doi: 10.1016/j.cub.2015.09.039.

Schwarz, L. A., Miyamichi, K., Gao, X. J., Beier, K. T., Weissbourd, B., DeLoach, K. E., … & Luo, L. (2015). Viral-genetic tracing of the input-output organization of a central noradrenaline circuit. Nature, 524(7563), 88-92. doi: 10.1038/nature14600.

Recommended Readings: David Schneider, Ph.D., March 14

Special Seminar
Friday, March 14
4:00 p.m., Carson Family Auditorium (CRC)

David Schneider, Ph.D.
Postdoctoral Fellow,
Department of Neurobiology,
Duke University

Sensory and Motor Circuits for Listening and Learning

Recommended Readings

Empirical Articles

Nelson, A., Schneider, D. M., Takatoh, J., Sakurai, K., Wang, F., & Mooney, R. (2013). A circuit for motor cortical modulation of auditory cortical activity. The Journal of Neuroscience, 33(36), 14342-14353. doi: 10.1523/JNEUROSCI.2275-13.2013.

Schneider, D. M., Nelson, A., & Mooney, R. (2014). A synaptic and circuit basis for corollary discharge in the auditory cortex. Nature, 513(7517), 189-194. doi: 10.1038/nature13724.

Schneider, D. M., & Woolley, S. M. (2013). Sparse and background-invariant coding of vocalizations in auditory scenes. Neuron, 79(1), 141-152. doi: 10.1016/j.neuron.2013.04.038.

Review Paper

Schneider, D. M., & Mooney, R. (2015). Motor-related signals in the auditory system for listening and learning. Current Opinion in Neurobiology, 33, 78-84. doi: 10.1016/j.conb.2015.03.004.

Recommended Readings: Talia Lerner, Ph.D., March 10

Special Lecture Series
Thursday, March 10, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Talia Lerner, Ph.D.
Postdoctoral Fellow,
Department of Bioengineering,
Stanford University

Distinct Information Encoding in Circuit-Defined Nigrostriatal Dopamine Neuron Subpopulations

Recommended Reading

Adhikari, A., Lerner, T. N., Finkelstein, J., Pak, S., Jennings, J. H., Davidson, T. J., … & Kim, S. Y. (2015). Basomedial amygdala mediates top-down control of anxiety and fear. Nature,  527(7577), 179-185. doi: 10.1038/nature15698

Lerner, T. N., Shilyansky, C., Davidson, T. J., Evans, K. E., Beier, K. T., Zalocusky, K. A., … & Deisseroth, K. (2015). Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits. Cell, 162(3), 635-647. doi: 10.1016/j.cell.2015.07.014.

Recommended Readings: Priya Rajasethupathy, M.D., Ph.D., January 25

Special Lecture
Monday, January 25, 2016
3:45 p.m., Carson Family Auditorium (CRC)

Priya Rajasethupathy, M.D., Ph.D.
Life Sciences Research Foundation Postdoctoral Fellow,
Department of Bioengineering,
Stanford University

Targeted Top-down Control of Memory Retrieval

Recommended Reading

Fiumara, F., Rajasethupathy, P., Antonov, I., Kosmidis, S., Sossin, W. S., & Kandel, E. R. (2015). MicroRNA-22 gates long-term heterosynaptic plasticity in Aplysia through presynaptic regulation of CPEB and downstream targets. Cell Reports, 11(12), 1866-1875. doi: 10.1016/j.celrep.2015.05.034.

Rajasethupathy, P., Antonov, I., Sheridan, R., Frey, S., Sander, C., Tuschl, T., & Kandel, E. R. (2012). A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity. Cell, 149(3), 693-707. doi: 10.1016/j.cell.2012.02.057.

Rajasethupathy, P., Sankaran, S., Marshel, J. H., Kim, C. K., Ferenczi, E., Lee, S. Y., … & Liston, C. (2015). Projections from neocortex mediate top-down control of memory retrieval. Nature, 526(7575), 653-659. doi: 10.1038/nature15389.

Recommended Readings: Jonas Frisén, M.D., Ph.D., October 16th

Friday Lecture Series
Friday, October 16, 2015
3:45 p.m., Caspary Auditorium

Jonas Frisén, M.D., Ph.D.
Tobias Foundation Professor of Stem Cell Research,
Department of Cell and Molecular Biology,
Karolinska Institutet, Stockholm, Sweden

Cellular Plasticity in the Intact and Injured Central Nervous System

Recommended Readings

Empirical Articles

Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., … & Frisén, J. (2014). Neurogenesis in the striatum of the adult human brain. Cell, 156(5), 1072-1083. doi: 10.1016/j.cell.2014.01.044

Magnusson, J. P., Göritz, C., Tatarishvili, J., Dias, D. O., Smith, E. M., Lindvall, O., … & Frisén, J. (2014). A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science, 346(6206), 237-241. doi: 10.1126/science.346.6206.237.

Sabelström, H., Stenudd, M., Réu, P., Dias, D. O., Elfineh, M., Zdunek, S., … & Frisén, J. (2013). Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Science, 342(6158), 637-640. doi: 10.1126/science.1242576

Review Paper

Bergmann, O., Spalding, K. L., & Frisén, J. (2015). Adult neurogenesis in humans. Cold Spring Harbor Perspectives in Biology, 7(7), a018994. doi: 10.1101/cshperspect.a018994

Recommended Readings: Gulcin Pekkurnaz, Ph.D., September 21

Special Lecture
Monday, September 21, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gulcin Pekkurnaz, Ph.D.,
Postdoctoral Fellow,
Department of Neurobiology,
Harvard Medical School
Boston Children’s Hospital

Metabolic Regulation of Mitochondrial Function in the Nervous System

Recommended Readings

Empirical Articles

Pekkurnaz, G., Trinidad, J. C., Wang, X., Kong, D., & Schwarz, T. L. (2014). Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell, 158(1), 54-68. doi: 10.1016/j.cell.2014.06.007

Teodoro, R. O., Pekkurnaz, G., Nasser, A., Higashi‐Kovtun, M. E., Balakireva, M., McLachlan, I. G., … & Schwarz, T. L. (2013). Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst. The EMBO Journal, 32(14), 2039-2055. doi: 10.1038/emboj.2013.147

Review Papers

Schwarz, T. L. (2013). Mitochondrial trafficking in neurons. Cold Spring Harbor Perspectives in Biology, 5(6), a011304. doi: 10.1101/cshperspect.a011304

Recommended Readings: Pietro De Camilli, M.D., February 13

Friday Lecture Series
Friday, February 13, 2015
3:45 p.m., Caspary Auditorium

Pietro De Camilli, M.D.
John Klingenstein Professor of Neuroscience,
Professor of Cell Biology,
Director, Program in Cellular Neuroscience, Neurodegeneration, and Repair,
Yale University School of Medicine
Investigator, Howard Hughes Medical Institute

Lipid Signaling in the Control of Membrane Dynamics and Interactions

Recommended Readings

Empirical Articles

Giordano, F., Saheki, Y., Idevall-Hagren, O., Colombo, S. F., Pirruccello, M., Milosevic, I., … De Camilli, P. (2013). PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell, 153(7), 1494–1509. doi:10.1016/j.cell.2013.05.026

Schauder, C. M., Wu, X., Saheki, Y., Narayanaswamy, P., Torta, F., Wenk, M. R., … Reinisch, K. M. (2014). Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature, 510(7506), 552–555. doi:10.1038/nature13269

Wu, X., Chi, R., Baskin, J., Lucast, L., Burd, C., DeCamilli, P., & Reinisch, K. (2014). Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Developmental Cell, 28(1), 19–29. doi:10.1016/j.devcel.2013.11.012

Review Paper

Idevell-Hagren, O., & De Camilli, P. (In Press). Detection and manipulation of phosphoinositides. Biochimica et Biophysica Acta Journal. doi:10.1016/j.bbalip.2014.12.008

Was the Cerebellum the Center of Evolutionary Change That Makes Us Human?

When we search for the seat of humanity, are we looking at the wrong part of the brain? Most neuroscientists assume that the neocortex, the brain’s distinctive folded outer layer, is the thing that makes us uniquely human. But a new study suggests that another part of the brain, the cerebellum, grew much faster in our ape ancestors.

Read more on this new research in Current Biology.