Recommended Readings: Jonas Frisén, M.D., Ph.D., October 16th

Friday Lecture Series
Friday, October 16, 2015
3:45 p.m., Caspary Auditorium

Jonas Frisén, M.D., Ph.D.
Tobias Foundation Professor of Stem Cell Research,
Department of Cell and Molecular Biology,
Karolinska Institutet, Stockholm, Sweden

Cellular Plasticity in the Intact and Injured Central Nervous System

Recommended Readings

Empirical Articles

Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., … & Frisén, J. (2014). Neurogenesis in the striatum of the adult human brain. Cell, 156(5), 1072-1083. doi: 10.1016/j.cell.2014.01.044

Magnusson, J. P., Göritz, C., Tatarishvili, J., Dias, D. O., Smith, E. M., Lindvall, O., … & Frisén, J. (2014). A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science, 346(6206), 237-241. doi: 10.1126/science.346.6206.237.

Sabelström, H., Stenudd, M., Réu, P., Dias, D. O., Elfineh, M., Zdunek, S., … & Frisén, J. (2013). Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Science, 342(6158), 637-640. doi: 10.1126/science.1242576

Review Paper

Bergmann, O., Spalding, K. L., & Frisén, J. (2015). Adult neurogenesis in humans. Cold Spring Harbor Perspectives in Biology, 7(7), a018994. doi: 10.1101/cshperspect.a018994

Recommended Readings: Gulcin Pekkurnaz, Ph.D., September 21

Special Lecture
Monday, September 21, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Gulcin Pekkurnaz, Ph.D.,
Postdoctoral Fellow,
Department of Neurobiology,
Harvard Medical School
Boston Children’s Hospital

Metabolic Regulation of Mitochondrial Function in the Nervous System

Recommended Readings

Empirical Articles

Pekkurnaz, G., Trinidad, J. C., Wang, X., Kong, D., & Schwarz, T. L. (2014). Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell, 158(1), 54-68. doi: 10.1016/j.cell.2014.06.007

Teodoro, R. O., Pekkurnaz, G., Nasser, A., Higashi‐Kovtun, M. E., Balakireva, M., McLachlan, I. G., … & Schwarz, T. L. (2013). Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst. The EMBO Journal, 32(14), 2039-2055. doi: 10.1038/emboj.2013.147

Review Papers

Schwarz, T. L. (2013). Mitochondrial trafficking in neurons. Cold Spring Harbor Perspectives in Biology, 5(6), a011304. doi: 10.1101/cshperspect.a011304

Recommended Readings: Pietro De Camilli, M.D., February 13

Friday Lecture Series
Friday, February 13, 2015
3:45 p.m., Caspary Auditorium

Pietro De Camilli, M.D.
John Klingenstein Professor of Neuroscience,
Professor of Cell Biology,
Director, Program in Cellular Neuroscience, Neurodegeneration, and Repair,
Yale University School of Medicine
Investigator, Howard Hughes Medical Institute

Lipid Signaling in the Control of Membrane Dynamics and Interactions

Recommended Readings

Empirical Articles

Giordano, F., Saheki, Y., Idevall-Hagren, O., Colombo, S. F., Pirruccello, M., Milosevic, I., … De Camilli, P. (2013). PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell, 153(7), 1494–1509. doi:10.1016/j.cell.2013.05.026

Schauder, C. M., Wu, X., Saheki, Y., Narayanaswamy, P., Torta, F., Wenk, M. R., … Reinisch, K. M. (2014). Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature, 510(7506), 552–555. doi:10.1038/nature13269

Wu, X., Chi, R., Baskin, J., Lucast, L., Burd, C., DeCamilli, P., & Reinisch, K. (2014). Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Developmental Cell, 28(1), 19–29. doi:10.1016/j.devcel.2013.11.012

Review Paper

Idevell-Hagren, O., & De Camilli, P. (In Press). Detection and manipulation of phosphoinositides. Biochimica et Biophysica Acta Journal. doi:10.1016/j.bbalip.2014.12.008

Was the Cerebellum the Center of Evolutionary Change That Makes Us Human?

When we search for the seat of humanity, are we looking at the wrong part of the brain? Most neuroscientists assume that the neocortex, the brain’s distinctive folded outer layer, is the thing that makes us uniquely human. But a new study suggests that another part of the brain, the cerebellum, grew much faster in our ape ancestors.

Read more on this new research in Current Biology.


Recommended Readings: Susan L. Ackerman, Ph.D. May 2

Friday Lecture Series
Friday, April 25, 2014
3:45 p.m., Caspary Auditorium

Susan L. Ackerman, Ph.D.
Professor, The Jackson Laboratory
Investigator, Howard Hughes Medical Institute

Multicopy Genes Encoding Functional RNAs and Their Role in the CNS

Recommended Readings:

Empirical Articles

Jia, Y., Mu, J. C., & Ackerman, S. L. (2012). Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration. Cell, 148(1-2), 296–308. doi:10.1016/j.cell.2011.11.057

Liu, Y., Zaun, H. C., Orlowski, J., & Ackerman, S. L. (2013). CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis. The Journal of Neuroscience, 33(31), 12656–12669. doi:10.1523/JNEUROSCI.0406-13.2013

Zhao, L., Longo-Guess, C., Harris, B. S., Lee, J.-W., & Ackerman, S. L. (2005). Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP. Nature Genetics, 37(9), 974–979. doi:10.1038/ng1620

Review Papers

Cooper, T. A, Wan, L., & Dreyfuss, G. (2009). RNA and disease. Cell, 136(4), 777–793. doi:10.1016/j.cell.2009.02.011

Lemmens, R., Moore, M. J., Al-Chalabi, A., Brown, R. H., & Robberecht, W. (2010). RNA metabolism and the pathogenesis of motor neuron diseases. Trends in Neurosciences, 33(5), 249–258. doi:10.1016/j.tins.2010.02.003