Recommended Readings: John Hardy, Ph.D. Friday September 7, 2018

Friday Lectures

Friday, September 7, 2018  3:45 p.m.

Caspary Auditorium

John Hardy Ph.D.

Head of the Department of Molecular Neuroscience

Chair of the Molecular Biology of Neurological Disease

University College London

Genomic Analysis of Alzheimer’s Disease and other Neurodegenerative Disorders

Recommended Readings:

Science News

Rebecca Hiscott. AT THE BENCH: John Hardy, PhD, on Unraveling the Genetics of Alzheimer’s Disease and Attending the ‘Oscars of Science’. January 7, 2016. Neurology Today

Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk. November 14, 2012. ALZFORUM

Empirical Articles

Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; et al. (2018). Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA NEUROLOGY. 75 (7)860-875 

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; et al. (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. NATURE GENETICS. 49 (9)1373-+ 

Wang, Yaming; Cella, Marina; Mallinson, Kaitlin; et al. (2015).TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model. CELL. 160 (6):1061-1071

Nalls, Mike A.; Pankratz, Nathan; Lill, Christina M.; et al. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. NATURE GENETICS. 46 (9)989-+

Guerreiro, Rita; Wojtas, Aleksandra; Bras, Jose; et al. (2013). TREM2 Variants in Alzheimer’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 368 (2): 355-358

Jones, Lesley; Holmans, Peter A.; Hamshere, Marian L.; et al. (2010). Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer’s Disease. PLOS ONE. 5 (11)

Hardy, JDuff, KHardy, KGPerez-Tur, JHutton, M(1998). Genetic dissection of Alzheimer’s disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1 (5): 355 – 358

Hardy JA, Higgins GA. (1992). Alzheimer’s disease: the amyloid cascade hypothesis. Science. 256 5054):184-5

Review Paper

Hardy, John. (2017). The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”. FEBS JOURNAL. 284 (7): 1040-1044

Selkoe, Dennis J.; Hardy, John. (2016). The amyloid hypothesis of Alzheimer’s disease at 25years. EMBO MOLECULAR MEDICINE. 8 (6)595-608

Hampel, Harald; Frank, Richard; Broich, Karl; et al. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. NATURE REVIEWS DRUG DISCOVERY. 9 (7)560-574

Book Chapter

Yu, Jin-Tai; Tan, Lan; Hardy, John. (2014). Apolipoprotein E in Alzheimer’s Disease: An Update. ANNUAL REVIEW OF NEUROSCIENCE. 3779-100

Hardy, John. (2012). Alzheimer’s disease and related dementias. NEUROGENETICS: A GUIDE FOR CLINICIANS. 17-31

Recommended Readings: Beth Stevens, Ph.D. Friday May 4, 2018

Friday Lectures

Friday, May 4, 2018  3:45 p.m.

Caspary Auditorium

Beth Stevens Ph.D.

Associate Professor

Department of Neurology

Harvard Medical School – Boston Children’s Hospital

How the Immune System Sculpts Brain Circuitry

Recommended Readings:

Science News

Beth Stevens and Todd E. Golden. Deciphering neurodegeneration: Inflammation, immune response, and Alzheimer’s. (Webinar – February 7, 2018). Science

Empirical Articles

Shi, Qiaoqiao; Chowdhury, Saba; Ma, Rong; et al. (2017). Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. SCIENCE TRANSLATIONAL MEDICINE. 9 (392)

Hong, Soyon; Beja-Glasser, Victoria F.; Nfonoyim, Bianca M.; et al. (2016). Complement and microglia mediate early synapse loss in Alzheimer mouse models. SCIENCE. 352 (6286): 712-716

Vasek, Michael J.; Garber, Charise; Dorsey, Denise; et al. (2016). A complement-microglial axis drives synapse loss during virus-induced memory impairment. NATURE. 534 (7608): 538-+

Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; et al. (2016). Schizophrenia risk from complex variation of complement component 4. NATURE. 530 (7589): 177-+

Schafer, Dorothy P.; Lehrman, Emily K.; Heller, Christopher T.; et al. (2014). An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 88

Schafer, Dorothy P.; Lehrman, Emily K.; Kautzman, Amanda G.; et al. (2012). Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner. NEURON. 74 (4): 691-705

Review Paper

Salter, Michael W.; Stevens, Beth. (2017). Microglia emerge as central players in brain disease. NATURE MEDICINE. 23 (9): 1018-1027

Hong, Soyon; Dissing-Olesen, Lasse; Stevens, Beth. (2016). New insights on the role of microglia in synaptic pruning in health and disease. CURRENT OPINION IN NEUROBIOLOGY. 36: 128-134  

Bilimoria, Parizad M.; Stevens, Beth. (2015). Microglia function during brain development: New insights from animal models. BRAIN RESEARCH. 1617: 7-17  

Book Chapter

Stephan, Alexander H.; Barres, Ben A.; Stevens, Beth. (2012). The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease.  ANNUAL REVIEW OF NEUROSCIENCE. 35: 369-389

Recommended Readings: Rachel Wilson, Ph.D. Friday December 15th, 2017

Friday Lectures

Friday, December 15, 2017  3:45 p.m.

Caspary Auditorium

Rachel Wilson, Ph.D.

Martin Family Professor

Department of Neurobiology

Harvard Medical School

Neural Correlates of Orienting Behaviors and Latent Action Biases

 

Recommended Readings:

Empirical Articles

Azevedo, Anthony W.; Wilson, Rachel I. (2017). Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons. NEURON. 96 (2): 446-+

Tobin, William F.; Wilson, Rachel I.; Lee, Wei-Chung Allen (2017). Wiring variations that enable and constrain neural computation in a sensory microcircuit. ELIFE. 6: e24838

Tuthill, John C.; Wilson, Rachel I. (2016). Parallel Transformation of Tactile Signals in Central Circuits of Drosophila. CELL. 164 (5): 1046-1059

Chang, Allison E. B.; Vaughan, Alex G.; Wilson, Rachel I. (2016). A Mechanosensory Circuit that Mixes Opponent Channels to Produce Selectivity for Complex Stimulus Features. NEURON. 92 (4): 888-901  

Jeanne, James M.; Wilson, Rachel I. (2015). Convergence, Divergence, and Reconvergence in a Feedforward Network Improves Neural Speed and Accuracy. NEURON. 88 (5)

Olsen, Shawn R.; Wilson, Rachel I. (2008). Lateral presynaptic inhibition mediates gain control in an olfactory circuit. NATURE. 452 (7190): 956-U3

Review Papers

Tuthill, John C.; Wilson, Rachel I. (2016). Mechanosensation and Adaptive Motor Control in Insects. CURRENT BIOLOGY. 26 (20): R1022-R1038

Olsen, Shawn R.; Wilson, Rachel I. (2008). Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. TRENDS IN NEUROSCIENCES. 31(10): 512-520

Book Chapter

Wilson, Rachel I. (2013). Early Olfactory Processing in Drosophila: Mechanisms and Principles. ANNUAL REVIEW OF NEUROSCIENCE. Book Series: Annual Review of Neuroscience. 36: 217-241

 

 

 

 

Recommended Readings: Timothy Ryan, Ph.D., Monday October 23th, 2017

Monday Lectures

Monday, October 23, 2017  3:45 p.m.

Carson Family Auditorium

Timothy Ryan, Ph.D.

Tri-Institutional Professor

Department of biochemistry

Weill Cornell Medical College

The Cost of Thinking: Metabolic Fitness at the Synapse Level

Recommended Readings:

Jaime de Juan Sanz (2017). The surprising metabolism of “exercising” neurons. Plos Blogs

http://news.cornell.edu/stories/2017/01/brain-cells-mobilize-sugar-response-increased-activity

Ashrafi, Ghazaleh; Ryan, Timothy A. (2017). Glucose metabolism in nerve terminals. CURRENT OPINION IN NEUROBIOLOGY. 45:156-161

Ashrafi, Ghazaleh; Wu, Zhuhao; Farrell, Ryan J.; et al. (2017). GLUT4 Mobilization Supports Energetic Demands of Active Synapses. NEURON. 93 (3): 606-+

Jang, SoRi; Nelson, Jessica C.; Bend, Eric G.; et al. (2016). Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function. NEURON. 90 (2): 278-291

Magistretti, Pierre J.; Allaman, Igor (2015). A Cellular Perspective on Brain Energy Metabolism and Functional Imaging. NEURON. 86 (4): 883-901

Rangaraju, Vidhya; Calloway, Nathaniel; Ryan, Timothy A.(2014). Activity-Driven Local ATP Synthesis Is Required for Synaptic Function. CELL. 156 (4): 825-835

Recommended Readings: Nancy Kanwisher, Ph.D. March 10, 2017

Friday Lectures

Friday, March 10, 2017   3:45 p.m.

Caspary Auditorium

Nancy Kanwisher, Ph.D.

Walter A. Rosenblith Professor,

Department of Brain and Cognitive Sciences,

Massachusetts Institute of Technology

Functional Imaging of the Human Brain:  A Window into the Organization of the Human Mind

Recommended Readings:

http://nancysbraintalks.mit.edu/video/nancys-ted-talk-neural-portrait-human-mind

https://www.theguardian.com/science/neurophilosophy/2017/jan/05/face-selective-brain-region-continues-to-grow-in-adulthood

Osher, David E.; Saxe, Rebecca R.; Koldewyn, Kami; et al. (2016). Structural Connectivity Fingerprints Predict Cortical Selectivity for Multiple Visual Categories across Cortex. CEREBRAL CORTEX. 26(4): 1668-1683
Yovel, Galit; Belin, Pascal (2013). A unified coding strategy for processing faces and voices. TRENDS IN COGNITIVE SCIENCES. 17(6): 263-271
Kanwisher, Nancy (2010). Functional specificity in the human brain: A window into the functional architecture of the mind. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(25): 11163-11170
Kanwisher, Nancy; Yovel, Galit (2006). The fusiform face area: a cortical region specialized for the perception of faces. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 361(1476): 2109-2128


 

Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D.

Friday Lectures

Friday, February 24, 2017   3:45 p.m.

Caspary Auditorium

Jeffrey M. Friedman,  M.D., Ph.D.

Marilyn M. Simpson Professor and Head,

Laboratory of Molecular Genetics

The Rockefeller University

Leptin Physiology, Pathophysiology and

the Neural Circuit Regulating Body Weight

 

Recommended Readings:

Friedman, Jeffrey (2016). The long road to leptin. JOURNAL OF CLINICAL INVESTIGATION. 126(12): 4727-4734

Friedman, Jeffrey M.; Mantzoros, Christos S. (2015). 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium. METABOLISM-CLINICAL AND EXPERIMENTAL. 64(1): 1-4   PLEASE REQUEST FROM MARKUS LIBRARY

Bouret, Sebastien G.; Bates, Sarah H.; Chen, Stephen; et al. (2012). Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits. JOURNAL OF NEUROSCIENCE. 32(4): 1244-1252

Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. (2011). Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE. 14(12): 1562-U92

Davis, Jon F.; Choi, Derrick L.; Schurdak, Jennifer D.; et al. (2011). Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits BIOLOGICAL PSYCHIATRY. 69(7): 668-674

Mantzoros, Christos S.; Magkos, Faidon; Brinkoetter, Mary; et al. (2011). Leptin in human physiology and pathophysiology.  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 301(4): E567-E584

Wang, May-yun; Chen, Lijun; Clark, Gregory O.; et al. (2010). Leptin therapy in insulin-deficient type I diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(11): 4813-4819

Oral, EA; Simha, V; Ruiz, E; et al. (2002). Leptin-replacement therapy for lipodystrophy. NEW ENGLAND JOURNAL OF MEDICINE. 346(8): 570-578

 

 

Recommended Readings: Rebecca Saxe Ph.D. October 21, 2016

Friday Lecture Series

Friday October 21, 2016   3:45 p.m.

Caspary Auditorium

Rebecca Saxe, Ph.D.

Professor, MIT, Brain and Cognitive Sciences

It’s the Thought that counts: Progress in understanding the 

Neural basis of Theory of Mind

Recommended Readings:

 Chakroff, Alek; Dungan, James; Koster-Hale, Jorie; et al.  When minds matter for moral judgment: intent information is neurally encoded for harmful but not impure acts. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE   11(3):476-484    MARCH 2016

Jacoby, Nir; Bruneau, Emile; Koster-Hale, Jorie; et al.  Localizing Pain Matrix and Theory of Mind networks with both verbal and non-verbal stimuli. NEUROIMAGE  126:39-48     FEB 1 2016

Deen, Ben; Koldewyn, Kami; Kanwisher, Nancy; et al.  Functional Organization of Social Perception and Cognition in the Superior Temporal Sulcus. CEREBRAL CORTEX    25(11):4596-4609     NOV 2015

Bruneau, Emile G.; Cikara, Mina; Saxe, Rebecca.  Minding the Gap: Narrative Descriptions about Mental States Attenuate Parochial Empathy.  PLOS ONE                 10:e0140838     OCT 27 2015

Andrews-Hanna, Jessica R.; Saxe, Rebecca; Yarkoni, Tal   Contributions of episodic retrieval and mentalizing to autobiographical thought: Evidence from functional neuroimaging, resting-state connectivity, and fMRI meta-analyses. NEUROIMAGE   91:324-335   MAY 1 2014

Koster-Hale, Jorie; Saxe, Rebecca; Dungan, James; et al.  Decoding moral judgments from neural representations of intentions. PNAS   110(14): 5648-5653   APRIL 2 2013

Recommended Readings: Ole Kiehn Ph.D. October 14, 2016

Friday Lecture Series

Friday October 14, 2016   3:45 p.m.

Caspary Auditorium

Ole Kiehn, Ph.D.

Professor, Mammalian Locomotor Laboratory,

Dept. of Neuroscience, Karolinska Institut

Deciphering the Functional Organization of Neuronal Circuits

Controlling Locomotion

Recommended Readings:

Kiehn, Ole.  Decoding the organization of spinal circuits that control locomotion. NATURE REVIEWS NEUROSCIENCE    17(4): 224-238    APR 2016

Bouvier, Julien; Caggiano, Vittorio; Leiras, Roberto; et al. Descending Command Neurons in the Brainstem that Halt Locomotion. CELL   163(5): 1191-1203    NOV 19 2015

Patrick, Susan K.; Noah, J. Adam; Yang, Jaynie F.   Interlimb Coordination in Human Crawling Reveals Similarities in Development and Neural Control With Quadrupeds.JOURNAL OF NEUROPHYSIOLOGY   101(2): 603-613   FEB 2009

Stuart, Douglas G.; Hultborn, Hans. Thomas Graham Brown (1882-1965), Anders Lundberg (1920-), and the neural control of stepping. BRAIN RESEARCH REVIEWS  59(1) : 74-95   NOV 2008

Recommended Readings: Gaby Maimon, Ph.D., Sept 23, 2016

Friday Lecture Series

Head shot of Gaby Maimon

Gaby Maimon, Ph.D.

Assistant Professor
Laboratory of Integrative Brain Function

Quantitative Neural Computations in Behaving Drosophila

Recommended Readings:

Kim, A.J. et al. Cellular evidence for efference copy in Drosophila visuomotor processing. Nature Neuroscience. 18, 1247–1255 (2015).

Rien, D.; kern, R. and R. Kurtz.  Octopaminergic modulation of a fly visual motion-sensitive neuron during stimulation with naturalistic optic flow.  Frontiers in Bahavioral Neuroscience. 7, 155 (2013)

Maimon, G. Modulation of visual physiology by behavioral state in monkeys, mice, and flies. Current Opinions in Neurobiology. 21, 559–564 (2011).

Rosner, R. and A. K. Warzecha.  Relating neuronal to behavioral performance: variability of optomotor responses in the blowflyPLoS One.   6, 10:e26886 (2011)

Recommended Readings: Mary Jeanne Kreek, M.D., May 2

Monday Lecture Series
Monday, May 2, 2016
4:00 p.m., Carson Family Auditorium (CRC)

Mary Jeanne Kreek, M.D.
Senior Attending Physician,
The Rockefeller University Hospital
Patrick E. and Beatrice M. Haggerty Professor and Head,
Laboratory of the Biology of Addictive Diseases,
The Rockefeller University

50th Anniversary of First Research Paper on Methadone Maintenance Treatment: Update on Molecular, Neurobiological, Behavioral, and Genetic Research

Recommended Readings:

Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., … & Tischfield, J. A. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction. Proceedings of the National Academy of Sciences, 95(16), 9608-9613.

Butelman, E. R., Yuferov, V., & Kreek, M. J. (2012). κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends in Neurosciences, 35(10), 587-596. doi:10.1016/j.tins.2012.05.005.

Dole, V. P., Nyswander, M. E., & Kreek, M. J. (1966). Narcotic blockade. Archives of Internal Medicine, 118(4), 304-309. doi:10.1001/archinte.1966.00290160004002

Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience, 8(11), 1450-1457. doi:10.1038/nn1583

Reed, B., Butelman, E. R., Yuferov, V., Randesi, M., & Kreek, M. J. (2014). Genetics of opiate addiction. Current Psychiatry Reports, 16(11), 1-12. doi:10.1007/s11920-014-0504-6.