Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D. May 20, 2013

Posted on May 20, 2013 by Carol Feltes

Monday Lecture Series
To Eat or Not To Eat: Studies of a Complex Motivational Behavior
Jeffrey M. Friedman, M.D. , Ph.D.
Marilyn M. Simpson Professor, Laboratory of Molecular Genetics
Investigator, Howard Hughes Medical Institute
Carson Family Auditorium, CRC
4:00 p.m., Refreshments 3:45

Recommended Readings:

L Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. 2011. Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE . 14(12):1562-U92 DOI: 10.1038/nn.2977

Scott, Michael M.; Lachey, Jennifer L.; Sternson, Scott M.; et al. 2009. Leptin Targets in the Mouse Brain. JOURNAL OF COMPARATIVE NEUROLOGY. 514(5): 518-532 DOI: 10.1002/cne.22025

Adam, Tanja C.; Epel, Elissa S. 2007. Stress, eating and the reward system. Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior. Location: Naples, Florida, JUL 18-22, 2006. Society for the Study of Ingestive Behavior. PHYSIOLOGY & BEHAVIOR. 91(4, Sp. Issue SI): 449-458 DOI: 10.1016/j.physbeh.2007.04.011

Heisler, Lora K.; Jobst, Erin E.; Sutton, Gregory M.; et al 2006. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. NEURON. 51(2): 239-249 DOI: 10.1016/j.neuron.2006.06.004

Alon, T; Friedman, JM. 2006. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. JOURNAL OF NEUROSCIENCE . 26(2): 389-397 DOI: 10.1523/JNEUROSCI.1203-05.2006

Figlewicz, DP; Bennett, J; Evans, SB; et al. 2004. Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. BEHAVIORAL NEUROSCIENCE . 118(3): 479-487 DOI: 10.1037/0735-7044.118.3.479 REQUEST ARTICLE FROM MARKUS LIBRARY

Pinto, S; Roseberry, AG; Liu, HY; et al. 2004. Rapid rewiring of arcuate nucleus feeding circuits by leptin. SCIENCE . 304(5667): 110-115 DOI: 10.1126/science.

Recommended Readings: Maria M. Mota PhD March 13, 2013

Posted on March 13, 2013 by Carol Feltes

Special Seminar Series

Malaria Infection, Superinfection and Co-infections: From Simple Models to Complex Interactions

Maria M. Mota, PH.D.

Unit Leader, Malaria Unit

Instituto de Medicina Molecular

Monday March 18, 2013

Recommended Readings:

Pinkevych, Mykola; Petravic, Janka; Chelimo, Kiprotich; et al. 2012. The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection. PLOS COMPUTATIONAL BIOLOGY. 8(10): e1002729 DOI: 10.1371/journal.pcbi.1002729

Klein, Eili Y.; Smith, David L.; Laxminarayan, Ramanan; et al. 2012. Superinfection and the evolution of resistance to antimalarial drugs. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 279( 1743):3834-3842 DOI: 10.1098/rspb.2012.1064

Portugal, Silvia; Drakesmith, Hal; Mota, Maria M. 2011. Superinfection in malaria: Plasmodium shows its iron will. EMBO REPORTS. 12(12):1233-1242 DOI: 10.1038/embor.2011.213

van Santen, Susanne; de Mast, Quirijn; Swinkels, Dorine W.; et al. 2011. Hepcidin in malaria superinfection: can findings be translated to humans? NATURE MEDICINE. 17(11):1341-1341 DOI: 10.1038/nm.2488

Portugal, Silvia; Carret, Celine; Recker, Mario; et al. 2011. Host-mediated regulation of superinfection in malaria. NATURE MEDICINE. 17(6):732-U126 DOI: 10.1038/nm.2368

Templeton, TJ; Keister, DB; Muratova, O; et al. 1998. Adherence of erythrocytes during exflagellation of Plasmodium falciparum microgametes is dependent on erythrocyte surface sialic acid and glycophorins. JOURNAL OF EXPERIMENTAL MEDICINE. 187(10 ):1599-1609 DOI: 10.1084/jem.187.10.1599

Recommended Readings: Robert Johnston, Jr. PhD Dec 10, 2012

Posted on October 9, 2012 by Carol Feltes

Controlling Stochastic Gene Expression in the Drosophila retina

Robert Johnston, Jr. PhD

Postdoctoral Fellow

Department of Biology, Center for Developmental Genetics

New York University

Monday, December 10, 2012

4 p.m. , Caspary Auditorium. Refreshments 3:45 p.m.

Recommended Readings:

Sood, P; Johnston, RJ Jr.;Kusssell, E. 2012. Stochastic de-repression of rhodopsins in single photoreceptors of the fly retina. PLoS Computational Biology. 8(2):e1002357. DOI:10.1371/journal.pcbi.1002357

Johnson, RJ, Jr.; Desplan, C. 2010. Stochastic mechanisms of cell fate specification that yield random or robust outcomes. Annual Review of Cell and Developmental Biology. 26:689-719. DOI:10.1146/annurev-cellbio-100109-104113

Jukam, D; Desplan, C. 2010. Binary date decisions in differentiating neurons. Current Opinion in Neurobiology. 20(1):6-13. DOI:10.1016/j.conb.2009.11.002

Wenet, MF; Mazzoni, EO; Ceclik A; et al. 2006. Stochastic spineless expression creates the retinal mosaic for colour vision. NATURE. 440(7081):174-180. DOI:10.1038/nature04615

Bell, ML; Earl, JB; Britt, SG. 2007. Two types of Drosophila R7 photoreceptor cells are arranged randomly: a model for stochastic cell-fate determination. Journal of Comparative Neurology. 502(1):75-85. DOI:10.1002/cne.21298.

Chanas, SA; Collinson, JM; Ramaesh, T; et al. 2009. Effects of elevated Pax6 expression and genetic background on mouse eye development. Investigative Ophthalmology and Visual Science. 50(9):4045-4059. DOI:10-1167/iovs.07-1630

Johnson, RJ Jr.; Desplan, C. 2008. Stochastic neuronal cell fate choices. Current Opinion in Neurobiology. 18(1):20-27. DOI:10.1016/j.conb.2008.04.004

Recommended Readings: Leslie M Turner PhD Oct 22, 2012

Posted on October 9, 2012 by Carol Feltes

Genomic Networks of Hybrid Sterility

Leslie M Turner PhD

Postdoctoral Fellow

Laboratory of Genetics, University of Wisconsin – Madison

Monday, October 22, 2012

4 p.m. , Caspary Auditorium. Refreshments 3:45 p.m.

Recommended Readings:

Janousek, V; Wang, LY; Luzynski, K; et al. 2012. Genome-wide architecture of reproductive isolation in naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus. Molecular Ecology. 21(12):3032-3047. DOI:10.111/j.1365-294X.2012.05583.x

White, MA; Steffy, B; Wiltshire, T; et al. 2011. Genetic dissection of a key reproductive barrier between nascent species of house mice. Genetics. 189(1):289-U988. DOI:10.1534/genetics.111.129171

Turner, LM; Schwahn, DJ; Harr, B. 2012. Reduced male fertility is common but highly variable in form and severity in a natural house mouse hybrid zone. Evolution. 66(2):443-458. DOI:10.1111/j.1558-5646.2011.01445.x

Turner, LM; Young, AR; Roempler, H; et al. 2010. Monogamy evolves through multiple mechanisms: evidence from V1aR in deer mice. Molecular Biology and Evolution. 27(6)1269-1278. DOI:10.1093/molbev/msq013

Harr, B; Turner, LM. 2010. Genome-wide analysis of alternative splicing evolution among Mus subspecies. Molecular Ecology. 19(suppl 1):228-239. DOI:10.1111/j.1365-294X.04490.x

Gompert, Z; Buerkle, CA. 2009. A powerful regression-based method for admixture mapping of isolation across the genome of hybrids. Molecular Ecology. 18(6):1207-1224. DOI:10.1111/j.1365-0294X.04098.x

Elliott, RW; Miller, DR; Pearsall, RS; et al. 2001. Genetic analysis of testis weight and fertility in an interspecies hybrid congenic strain for chromosome X. Mammalian Genome. 12(1):45-51. DOI:10.1007/s003350010234

Recommended Readings: Marco Tripodi PhD Oct 8 2012

Posted on September 20, 2012 by Carol Feltes

Spatiotemporal Control of Motor Circuit Assembly and Function

Marco Tripodi, Ph.D.

Postdoctoral Fellow

Biozentrum

University of Basel and

Friedrich Miescher Institute for Biomedical Research

Monday, October 8, 2012

4:00 p.m., Caspary Auditorium

Recommended Readings:

Arber, Silvia. 2012. Motor circuits in action: specification, connectivity and function. Neuron. 74(6):975-969 DOI: 10.1016/j.neuron.2012.05.011

Martin, John H. 2012. Systems neurobiology of restorative neurology and future directions for repair of the damaged motor systems. Clinical Neurobiology and Neurosurgery. 114(5, Sp.Issue S1):515-523. DOI: 10.1016/j.clineuro.2012.01.011 Please request from Markus Library.

Denk, W.; K.L. Briggman; M. Helmstaedter. 2012. Structural neurobiology: missing link t o a mechanistic understanding of neural computation. Nature Reviews Neuroscience. 13(5):351-358. DOI: 10.1038/nrn3169

Tripodi, M.; A. E. Stepien; and S. Arber. 2011. Motor antagonism exposed by spatial segregation and timing of neurogenesis. Nature. 479:7371:61-U84. DOI:10.1038/nature1038

Simon, M.A.; S. J. Fusillo; K. Colman, et al. 2010. Motor patterns associated with crawling in a soft-bodied arthropod. Journal of Experimental Biology. 213(13):2302-2309. DOI:10.1242/jeb.039206

Ugolini, G. 2010. Advances in viral transneuronal tracing. 7^th FENS Meeting on Neuroanatomical Tracing and Systems. Amsterdam, Netherlands, July 3, 2010. Journal of Neuroscience Methods. 194(1):2-20. DOI:10.1016/j.jneumeth.2009.12.001

Recommended Readings: Kazuhiro Yamada, PhD October 1, 2012

Posted on September 13, 2012 by Carol Feltes

Crystallographic Studies of Large Complexes: From the Yeast Chromatin

Remodeling Factor ISW1a to the Entire Nucleosome-Traversing

Transcription Machinery

Kazuhiro Yamada, PhD

Senior Scientist/Over-assistant

Institute of Molecular Biology and Biophysics

ETH Zurich

Monday, October 1, 2012

4 p.m. , Caspary Auditorium. Refreshments 3:45 p.m.

Recommended Readings:

Yen, K.; Vinayachandran, V.; Batta, K.; et al. 2012. Genome-wide Nucleosome Specificity and Directionality of Chromatin Remodelers. CELL 149(7):1461-1473 DOI: 10.1016/j.cell.2012.04.036

Richmond, Timothy J. 2012. Nucleosome recognition and spacing by chromatin remodelling factor ISW1a. BIOCHEMICAL SOCIETY TRANSACTIONS, 40: 347-350 DOI: 10.1042/BST20110748 Please request from Markus Library.

De Cian, A; Praly, E; Ding, F; et al. 2012. ATP-Independent Cooperative Binding of Yeast Isw1a to Bare and Nucleosomal DNA. PLOS ONE 7(2): e31845 DOI: 10.1371/journal.pone.0031845

Sharma, A.; Jenkins, K. R.; Heroux, A.; et al. 2011. Crystal Structure of the Chromodomain Helicase DNA-binding Protein 1 (Chd1) DNA-binding Domain in Complex with DNA. JOURNAL OF BIOLOGICAL CHEMISTRY 286(49):42099-42104 DOI: 10.1074/jbc.C111.294462

Yamada, K.; Frouws, T. D.; Angst, B.; et al. 2011. Structure and mechanism of the chromatin remodelling factor ISW1a. NATURE. 472(7344):U448-U536 DOI: 10.1038/nature09947

Pinskaya, M.; Nair, A.; Clynes, D.; et al. 2009. Nucleosome Remodeling and Transcriptional Repression Are Distinct Functions of Isw1 in Saccharomyces cerevisiae. MOLECULAR AND CELLULAR BIOLOGY 29(9): 2419-2430 DOI: 10.1128/MCB.01050-08

Recommended Readings: Yanick Crow, PhD September 17, 2012

Posted on September 6, 2012 by Carol Feltes

Reply

Human Type I Interferonopathies

Yanick Crow PhD

Professor of Genetic Medicine

University of Manchester, UK

Monday, September 17, 2012

4 p.m. , Caspary Auditorium. Refreshments 3:45 p.m.

Recommended Review:

Banchereau, J; Pascual, V. 2006. Type I interferon in systemic lupus erythematosus and other autoimmune diseases. IMMUNITY. 25( 3):383-392. DOI: 10.1016/j.immuni.2006.08.010

Recommended Readings:

Crow, Y. 2011. Type I interferonopathies: a novel set of inborn errors of immunity. Annals of the New York Academy of Sciences 1238: 91-98. DOI: 10.1111/j.1749-6632.2011.06220.x

Briggs, Tracy A.; Rice, Gillian I.; Daly, Sarah; et al. 2011. Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. NATURE GENETICS 43(2):127-U71. DOI: 10.1038/ng.748

Alcais, A; Quintana-Murci, L; Thaler, DS.; et al. 2010. Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity? Annals of the New York Academy of Sciences 1214:18-33. DOI: 10.1111/j.1749-6632.2010.05834.x

Crow, Yanick J. 2011. Lupus: How much “complexity” is really (just) genetic heterogeneity? ARTHRITIS AND RHEUMATISM. 63(12): 3661-3664 DOI: 10.1002/art.30603

Crow, Y.; Rehwinkel, J. 2009. Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity. HUMAN MOLECULAR GENETICS 18: R130-R136. DOI: 10.1093/hmg/ddp293

Baechler, EC; Batliwalla, FM; Karypis, G; et al. 2003. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100( 5):2610-2615. DOI: 10.1073/pnas.0337679100

Recommended Readings: Howard C Hang, PhD.

Posted on May 17, 2012 by Carol Feltes

Reply

Chemical Reporters for Exploring Posttranslational

Modifications in Innate Immunity

Howard C Hang, Ph.D.

Laboratory of Chemical Biology and Microbial Pathogenesis

The Rockefeller University

4:00 p.m. Monday, June 4, 2012 Refreshments 3:45 Abby Lounge

Caspary Auditorium

Recommended Readings

Yount JS, Charron G, Hang HC. 2012. Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetis enzymes. Bioorganic & Medicinal Chemistry. 20(2, S1):650-654. DOI: 0.1016/j.bmc.2011.03.062

Lei YL, Xie K. et al. 2012. Chemistry-based functional proteomics to identify novel deubiquitylating enzymes involved in viral infection. Combinatorial Chemistry & High Throughput Screening. 15(4):316-327. Please request from Markus Library.

Grammel M, Dossa PD, Taylor-Salmon E, et al. 2012. II-selective labeling of bacterial proteomes with an orthogonal phenylalanine amino acid reporter. Chemical Communications. 48(10):1473-1474. DOI: 10.1039/c1cc14939c

Aguera-Gonzales S, Gross CC, Fernandez-Messina L, et al. 2011. Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding. European Journal of Immunology. 41(12):3667-3676. DOI: 10.1002/eji.20114165

Hao ZY, Hong SL, Chen X, et al. 2011. Introducing bioorthogonal functionalities into proteins in living cells. Accounts of Chemical Research 44(9, S1):742-751. DOI: 10.1021/ar200067r

Hang HC, Linder ME. 2011. Exploring protein lipidation with chemical biology. Chemical Reviews. 111(10):6341-6358. DOI: 10.1021/cr2001977

Yang YY, Hang HC. 2011. Chemical approaches for the detection and synthesis of acetylated proteins. Chembiochem. 12(2):314-322. DOI: 10.1002/cbc.201000558

Recommended Readings: Shai Shaham PH.D. Monday, March 26, 2012

Posted on March 23, 2012 by Carol Feltes

Reply

A New C. elegans Cell Death Program: Implications for

Neurodegeneration and Cancer

Shai Shaham, Ph.D.

Laboratory of Developmental Genetics

The Rockefeller University

4:00 p.m. Monday, March 26, 2012 Refreshments 3:45 Abby Lounge

Caspary Auditorium

Recommended readings:

Blum, E.S., Abraham, M.C., Yoshimura, S., Lu, Y., and S. Shaham. 2012. Control of nonapoptotic developmental cell death in Caeanorhabditis elegans by a polyglutamic-repeat protein. Science. 335(6071):970-973. DOI: 10.1126/science.1215156

McCall, K. 2010. Generic control of necrosis – another type of programmed cell death. Current Opinion in Cell Biology. 22(6):882-888. DOI: 10.1016/j.ceb.2010.09.002

Yuan, J. and G. Kroemer. 2010. Alternative cell death mechanisms in development and beyond. Genes & Development. 24(23):2592-2602. DOI: 10.1101/gad.1984410

Vlachos, M. and N. Tavernarakis. 2010. Non-apoptotic cell death in Caenorhabditis elegans. Developmental Dynamics. 239(5, S1):1337-1351. DOI: 10.1002/dvdy.22230

Miguel-Aliaga, I. and T. Stefan. 2009. Programmed cell death in the nervous system – a programmed cell fate? Current Opinion in Neurobiology. 19(2):127-133 DOI: 10.1016/j.conb.2009.04.002

Blum, E.S., M. Driscoll, and S. Shaham. 2008. Noncanonical cell death programs in the nematode Caenorhabditis elegans. Cell Death and Differeentiation. 15(7):1124-1131. DOI: 10.1038/cdd.2008.56

Abraham, M. C., L. Yun, and S. Shaham. 2007. A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabiditis elegans. Development Cell. 12(1):73-86. DOI: 10.1016/j.devcel.2006.11.012

Erez Lieberman-Aiden Ph.D. Wednesday, April 4, 2012

Posted on March 22, 2012 by Carol Feltes

Reply

How the Genome Folds

Erez Aiden Ph.D.

Fellow, Harvard Society of Fellows

Prinicpal Investigator, Laboratory-at-Large

Harvard University

Visiting Faculty, Google

4:00 Wednesday, April 4, 2012 Refreshments Abby Lounge 3:45

Caspary Auditorium

Recommended Readings

Zhang Y; McCord RP, Ho YJ; et al. 2012. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell. 148(5):908-921. DOI: 10.1016/j.cell.2012.02.002

Sung MH and GL Hager. 2011. More to Hi-C than meets the eye. Nature Genetics. 43(11):1047-1048. DOI: 10.1038/ng.984

Yaffe E and A Tanay. 2011. Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture. Nature Genetics. 43(11):1059-U40. DOI: 10.1038/ng.947

Fudenberg G; Getz G; Meyerson M; et al. 2011. High order chromatic architecture shapes the landscape of chromosomal alterations in cancer. Nature Biotechnology. 29(12):1109-U75. DOI: 10.1038/nbt.2049

Lieberman-Aiden E; van Berkum NL; Williams L; et al. 2009. Comprehenesive mapping of long-range interactions reveals folding principles of the human genome. Science. 326(5950):289-293. DOI: 10.1126/science.1181369

Guelen L; Pagie L; Brasset E; et al. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature. 453(7197):948-U83. DOI: 10.1038/nature06947

Rada-Iglesias A; Ameur A; Kapronov P; et al. 2008. Whole-genome maps opf USA and USF2 binding and histone H3 acetylation reveal new aspects of prmotoer structure and candidate genes for common human disorders. Genome Research. 18(3):380-392. DOI: 10.1101/gr.6880908

Xiao G; Wang X; and Ab Khodursky. 2011. Modeling three-dimensional chromosome structures using gene expression data. Journal of the American Statistical Association. 106(493):61-72. DOI: 10.1198/jasa.2010/ap09504 Please request copy from Markus Library.