Recommended Readings: Leslie B. Vosshall, Ph.D. March 3, 2017

Friday Lectures

Friday, March 03, 2017   3:45 p.m.

Caspary Auditorium

Leslie B. Vosshall, Ph.D.

Robin Chemers Neustein Professor and Head,

Laboratory of Neurogenetics and Behavior,

The Rockefeller University


Recommended Readings:

Bezzina A. Malaria infection smells irresistible to mosquitoes. Cosmos. Feb 9 2017

Hurd H. Afraid of malaria? Get a chicken. BMC Blogs Network (blog). Aug 16 2016

Matthews, Benjamin J.; McBride, Carolyn S.; DeGennaro, Matthew; et al. (2016). The neurotranscriptome of the Aedes aegypti mosquito. BMC GENOMICS. 17(32)

Kistler, Kathryn E.; Vosshall, Leslie B.; Matthews, Benjamin J. (2015). Genome Engineering with CRISPR-Cas9 in the Mosquito Aedes aegypti. CELL REPORTS. 11(1): 51-60

McBride, Carolyn S.; Baier, Felix; Omondi, Aman B.; et al. (2014). Evolution of mosquito preference for humans linked to an odorant receptor. NATURE. 515(7526): 222-U151

McMeniman, Conor J.; Corfas, Roman A.; Matthews, Benjamin J.; et al. (2014). Multimodal Integration of Carbon Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans. CELL. 156(5): 1060-1071  

Takken, Willem; Verhulst, Niels O. (2013). Host Preferences of Blood-Feeding Mosquitoes.

Recommended Readings: Ian A. Wilson D. Phil., D. Sci., Friday February 10, 2017

Friday Lectures

Friday, February 10, 2017   3:45 p.m.

Caspary Auditorium

Ian A. Wilson  D. Phil., D.Sci.

Hansen Professor of Structural Biology, and

Chair, Dept. of Integrative Structural and Computational Biology

The Scripps Research Institute

Broad Neutralization of Influenza Viruses and

Implications for a Universal Vaccine and Therapy

Recommended Readings:

Dreyfus, Cyrille; Laursen, Nick S.; Kwaks, Ted; et al.  (2012). Highly Conserved Protective Epitopes on Influenza B Viruses.  SCIENCE, 337(6100): 1343-1348 

Walker, Laura M.; Huber, Michael; Doores, Katie J.; et al. (2011).  Broad neutralization coverage of HIV by multiple highly potent antibodiesNATURE , 477(7365): 466-U117

Ekiert, Damian C.; Friesen, Robert H. E.; Bhabha, Gira; et al. (2011).  A Highly Conserved Neutralizing Epitope on Group 2 Influenza A VirusesSCIENCE,  333(6044): 843-850 

Gottlieb, Tanya; Ben-Yedidia, Tamar.  (2014)  Epitope-based approaches to a universal influenza vaccine.  JOURNAL OF AUTOIMMUNITY.  54 (Special Issue: SI ):15-20 

He, Fang; Prabakaran, Mookkan; Kumar, Subaschandrabose Rajesh; et al. (2011), Monovalent H5 vaccine based on epitope-chimeric HA provides broad cross-clade protection against variant H5N1 viruses in miceANTIVIRAL RESEARCH,  105: 143-151 

Li, Zhuo; Gabbard, Jon D.; Mooney, Alaina; et al. (2013). Single-Dose Vaccination of a Recombinant Parainfluenza Virus 5 Expressing NP from H5N1 Virus Provides Broad Immunity against Influenza A Viruses.  JOURNAL OF VIROLOGY,  87(10): 5985-5993

Huber, Victor C.; Thomas, Paul G.; McCullers, Jonathan A. (2009).  A multi-valent vaccine approach that elicits broad immunity within an influenza subtypeVACCINE,  27(8): 1192-1200

Recommended Readings: Julie Segre, Ph.D., February 12

Friday Lecture Series
Friday, February 12, 2016
3:45 p.m., Caspary Auditorium

Julie Segre, Ph.D.,
Senior Investigator, Microbial Genomics Section,
Chief, Translational and Functional Genomics Branch,
National Human Genome Research Institute,
National Institutes of Health

Human Skin Microbiome in Health and Disease

Recommended Reading

Empirical Papers

Conlan, S., Thomas, P. J., Deming, C., Park, M., Lau, A. F., Dekker, J. P., … & Segre, J. A. (2014). Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae. Science Translational Medicine, 6(254), 254ra126-254ra126. doi: 10.1126/scitranslmed.3009845.

Naik, S., Bouladoux, N., Linehan, J. L., Han, S. J., Harrison, O. J., Wilhelm, C., … & Belkaid, Y. (2015). Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Nature, 520(7545), 104-108. doi: 10.1038/nature14052.

Oh, J., Byrd, A. L., Deming, C., Conlan, S., Kong, H. H., Segre, J. A., & NISC Comparative Sequencing Program. (2014). Biogeography and individuality shape function in the human skin metagenome. Nature, 514(7520), 59-64. doi: 10.1038/nature13786.

Review Article

Belkaid, Y., & Segre, J. A. (2014). Dialogue between skin microbiota and immunity. Science, 346(6212), 954-959. doi: 10.1126/science.1260144.

Recommended Readings: Luciano Marraffini, Ph.D., October 9th

Friday Lecture Series
Friday, October 9th, 2015
3:45 p.m., Caspary Auditorium

Luciano Marraffini, Ph.D.
Assistant Professor and Head,
Laboratory of Bacteriology,
The Rockefeller University

CRISPR-Cas: The Adaptive Immune System of Prokaryotes

Recommended Readings

Empirical Articles

Goldberg, G. W., Jiang, W., Bikard, D., & Marraffini, L. A. (2014). Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting. Nature, 514(7524), 633-637. doi:10.1038/nature13637.

Heler, R., Samai, P., Modell, J. W., Weiner, C., Goldberg, G. W., Bikard, D., & Marraffini, L. A. (2015). Cas9 specifies functional viral targets during CRISPR-Cas adaptation. Nature, 19(7542), 199-202. doi:10.1038/nature14245.

Jiang, W., Maniv, I., Arain, F., Wang, Y., Levin, B. R., & Marraffini, L. A. (2012). Dealing with the evolutionary downside of CRISPR immunity: bacteria and beneficial plasmids. PLoS Genetics, 9(9), e1003844-e1003844. doi:10.1371/journal.pgen.1003844.

Review Papers

Barrangou, R., & Marraffini, L. A. (2014). CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity. Molecular Cell, 54(2), 234-244. doi:10.1016/j.molcel.2014.03.011.

Hatoum-Aslan, A., & Marraffini, L. A. (2014). Impact of CRISPR immunity on the emergence and virulence of bacterial pathogens. Current Opinion in Microbiology, 17, 82-90. doi:10.1016/j.mib.2013.12.001

Recommended Readings: Susan Kaech, Ph.D., September 14th

Monday Lecture Series
Monday, September 14th, 2015
4:00 p.m., Carson Family Auditorium (CRC)

Susan Kaech, Ph.D.
Associate Professor of Immunobiology,
Yale School of Medicine
Early Career Scientist,
Howard Hughes Medical Institute

PEPing Up T Cell-mediated Immunity to Viruses and Cancer

Recommended Readings

Empirical Articles

Cui, G., Staron, M. M., Gray, S. M., Ho, P. C., Amezquita, R. A., Wu, J., & Kaech, S. M. (2015). IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell, 161(4), 750-761. doi:10.1016/j.cell.2015.03.021.

Laidlaw, B. J., Cui, W., Amezquita, R. A., Gray, S. M., Guan, T., Lu, Y., … & Kaech, S. M. (2015). Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells. Nature Immunology, 16(8), 871-879. doi:10.1038/ni.3224

Laidlaw, B. J., Zhang, N., Marshall, H. D., Staron, M. M., Guan, T., Hu, Y., … & Kaech, S. M. (2014). CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity, 41(4), 633-645. doi:10.1016/j.immuni.2014.09.007.

Slütter, B., Pewe, L. L., Kaech, S. M., & Harty, J. T. (2013). Lung airway-surveilling CXCR3 hi memory CD8+ T cells are critical for protection against influenza A virus. Immunity, 39(5), 939-948. doi:10.1016/j.immuni.2013.09.013.

Review Paper

Gray, S. M., Kaech, S. M., & Staron, M. M. (2014). The interface between transcriptional and epigenetic control of effector and memory CD8+ T‐cell differentiation. Immunological Reviews, 261(1), 157-168. doi:10.1111/imr.12205.

Kaech, S. M., & Cui, W. (2012). Transcriptional control of effector and memory CD8+ T cell differentiation. Nature Reviews Immunology, 12(11), 749-761. doi:10.1038/nri3307.

Recommended Readings: W. Ian Lipkin, M.D., May 29th

Friday Lecture Series
Friday, May 29, 2015
3:45 p.m., Caspary Auditorium

W. Ian Lipkin, M.D.
John Snow Professor of Epidemiology,
Mailman School of Public Health
Professor of Neurology and Pathology,
College of Physicians and Surgeons
Director, Center for Infection and Immunity, C
Columbia University

Small Game Hunting

Recommended Readings

Empirical Articles

Cox-Foster, D. L., Conlan, S., Holmes, E. C., Palacios, G., Evans, J. D., Moran, N. A., … & Lipkin, W. I. (2007). A metagenomic survey of microbes in honey bee colony collapse disorder. Science, 318(5848), 283-287.

Memish, Z. A., Mishra, N., Olival, K. J., Fagbo, S. F., Kapoor, V., Epstein, J. H., … & Lipkin, W. I. (2013). Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerging Infectious Diseases, 19(11), 1819-1823. doi:10.3201/eid1911.131172

Negredo, A., Palacios, G., Vázquez-Morón, S., González, F., Dopazo, H., Molero, F., … & Tenorio, A. (2011). Discovery of an ebolavirus-like filovirus in europe. PLoS Pathogens, 7(10), e1002304. doi:10.1371/journal.ppat.1002304

Palacios, G., Druce, J., Du, L., Tran, T., Birch, C., Briese, T., … & Lipkin, W. I. (2008). A new arenavirus in a cluster of fatal transplant-associated diseases. New England Journal of Medicine, 358(10), 991-998. doi:10.1056/NEJMoa073785

Review Papers

Lipkin, W. I. (2013). The changing face of pathogen discovery and surveillance. Nature Reviews Microbiology, 11(2), 133-141. doi:10.1038/nrmicro2949

Lipkin, W. I. (2010). Microbe hunting. Microbiology and Molecular Biology Reviews, 74(3), 363-377. doi:10.1128/MMBR.00007-10

Lipkin, W. I., & Anthony, S. J. (2015). Virus hunting. Virology. doi:10.1016/j.virol.2015.02.006

Recommended Readings: Jean-Laurent Casanova, M.D., Ph.D., March 6

Friday Lecture Series / Ph.D. Recruitment Lecture
Friday, March 6, 2015
3:45 p.m., Caspary Auditorium

Jean-Laurent Casanova, M.D., Ph.D.,
Senior Attending Physician, Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Infectious Diseases of Childhood: Inborn Errors of Immunity?

Recommended Readings

Empirical Articles

Casrouge, A., Zhang, S.-Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., … Casanova, J.-L. (2006). Herpes simplex virus encephalitis in human UNC-93B deficiency. Science, 314(5797), 308–312. doi:10.1126/science.1128346

Taramasso, L., Boisson-Dupuis, S., Garre, M. L., Bondi, E., Cama, a, Nozza, P., … Marazzi, M. G. (2014). Pineal germinoma in a child with interferon-gamma receptor 1 deficiency. case report and literature review. Journal of Clinical Immunology, 34(8), 922–927. doi:10.1007/s10875-014-0098-0

Von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C.-L., … Casanova, J.-L. (2008). Pyogenic bacterial infections in humans with MyD88 deficiency. Science, 321(5889), 691–696. doi:10.1126/science.1158298

Review Papers

Casanova, J.-L., & Abel, L. (2002). Genetic dissection of immunity to mycobacteria: the human model. Annual Review of Immunology, 20, 581–620. doi:10.1146/annurev.immunol.20.081501.125851

Casanova, J.-L., & Abel, L. (2013). The genetic theory of infectious diseases: a brief history and selected illustrations. Annual Review of Genomics and Human Genetics, 14, 215–243. doi:10.1146/annurev-genom-091212-153448

Conley, M. E., & Casanova, J. L. (2014). Discovery of single-gene inborn errors of immunity by next generation sequencing. Current Opinion in Immunology, 30, 17–23. doi:10.1016/j.coi.2014.05.004

Recommended Readings: Jorge E. Galán, Ph.D., DVM, February 6

Friday Lecture Series
Friday, February 6, 2015
3:45 p.m., Caspary Auditorium

Jorge E. Galán, Ph.D., DVM
Lucille P. Markey Professor of Microbial Pathogenesis,
Professor of Cell Biology,
Chair, Department of Microbial Pathogenesis,
Yale University School of Medicine

Typhoid fever: new insight into the pathogenesis of an old disease

Recommended Readings

Empirical Articles

Lefebre, M. D., & Galán, J. E. (2014). The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Proceedings of the National Academy of Sciences, 111(2), 817–822. doi:10.1073/pnas.1319698111

Song, J., Gao, X., & Galán, J. E. (2013). Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature, 499(7458), 350–354. doi:10.1038/nature12377

Spanò, S., & Galán, J. E. (2012). A Rab32-dependent pathway contributes to Salmonella typhi host restriction. Science, 338(6109), 960–963. doi:10.1126/science.1229224

Review Papers

Hicks, S. W., & Galán, J. E. (2013). Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Nature Reviews Microbiology, 11(5), 316–326. doi:10.1038/nrmicro3009

Recommended Readings: Stephen C. Harrison, Ph.D. November 21

Friday Lecture Series
Friday, November 21, 2014,
3:45 p.m., Caspary Auditorium

Stephen C. Harrison, Ph.D.
Giovanni Armenise-Harvard Professor of Basic Medical Sciences,
Professor of Biological Chemistry and Molecular Pharmacology,
Professor of Pediatrics,
Director of the Center for Molecular and Cellular Dynamics,
Harvard Medical School
Head of the Laboratory of Molecular Medicine,
Children’s Hospital, Boston
Howard Hughes Medical Institute

Molecular Mechanisms of Membrane Penetration When Viruses Enter Cells

Recommended Readings

Empirical Articles

Abdelhakim, A. H., Salgado, E. N., Fu, X., Pasham, M., Nicastro, D., Kirchhausen, T., & Harrison, S. C. (2014). Structural correlates of rotavirus cell entry. PLoS Pathogens, 10(9), e1004355. doi:10.1371/journal.ppat.1004355

Ivanovic, T., Choi, J. L., Whelan, S. P., van Oijen, A. M., & Harrison, S. C. (2013). Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. eLife, 2(1), e00333. doi:10.7554/eLife.00333

Schmidt, A. G., Xu, H., Khan, A. R., O’Donnell, T., Khurana, S., King, L. R., … Harrison, S. C. (2013). Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences, 110(1), 264–269. doi:10.1073/pnas.1218256109

Review Article

Harrison, S. C. (2008). Viral membrane fusion. Nature Structural & Molecular Biology, 15(7), 690–698. doi:10.1038/nsmb.1456

Recommended Readings: Jean-Laurent Casanova, Ph.D. December 1

Monday Lecture Series
Monday, December 1, 2014,
4:00 p.m., Carson Family Auditorium (CRC)

Jean-Laurent Casanova, Ph.D.,
Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Howard Hughes Medical Institute

Toward a Genetic Theory of Childhood Infectious Diseases

Recommended Readings

Empirical Articles

Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., … Casanova, J.-L. (2011). Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science, 332(6025), 65–68. doi:10.1126/science.1200439

Sabri, A., Grant, A. V, Cosker, K., El Azbaoui, S., Abid, A., Abderrahmani Rhorfi, I., … El Baghdadi, J. (2014). Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco. The Journal of Infectious Diseases, 210(4), 611–618. doi:10.1093/infdis/jiu140

Review Papers

Alcaïs, A., Quintana-Murci, L., Thaler, D. S., Schurr, E., Abel, L., & Casanova, J.-L. (2010). Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity? Annals of the New York Academy of Sciences, 1214, 18–33. doi:10.1111/j.1749-6632.2010.05834.x

Casanova, J.-L., & Abel, L. (2005). Inborn errors of immunity to infection: the rule rather than the exception. The Journal of Experimental Medicine, 202(2), 197–201. doi:10.1084/jem.20050854