Recommended Readings: Jean-Laurent Casanova, Ph.D. December 1

Monday Lecture Series
Monday, December 1, 2014,
4:00 p.m., Carson Family Auditorium (CRC)

Jean-Laurent Casanova, Ph.D.,
Professor and Head,
St. Giles Laboratory of Human Genetics of Infectious Diseases,
The Rockefeller University
Howard Hughes Medical Institute

Toward a Genetic Theory of Childhood Infectious Diseases

Recommended Readings

Empirical Articles

Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., … Casanova, J.-L. (2011). Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science, 332(6025), 65–68. doi:10.1126/science.1200439

Sabri, A., Grant, A. V, Cosker, K., El Azbaoui, S., Abid, A., Abderrahmani Rhorfi, I., … El Baghdadi, J. (2014). Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco. The Journal of Infectious Diseases, 210(4), 611–618. doi:10.1093/infdis/jiu140

Review Papers

Alcaïs, A., Quintana-Murci, L., Thaler, D. S., Schurr, E., Abel, L., & Casanova, J.-L. (2010). Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity? Annals of the New York Academy of Sciences, 1214, 18–33. doi:10.1111/j.1749-6632.2010.05834.x

Casanova, J.-L., & Abel, L. (2005). Inborn errors of immunity to infection: the rule rather than the exception. The Journal of Experimental Medicine, 202(2), 197–201. doi:10.1084/jem.20050854

NIH: without budget cuts, we’d have Ebola vaccine

By Fiona Barry, 22-Oct-2014

The head of the US National Institutes of Health has said the organisation would have developed a finished Ebola vaccine by now if its funding had not been slashed over the last decade.

Recommended Readings: Poornima Parameswaran Ph.D. February 10

Monday, February 10, 2014
4:00 p.m., Carson Family Auditorium

Poornima Parameswaran, Ph.D.

Postdoctoral Research Fellow
School of Public Health
University of California, Berkeley

Virome & Immunome Diversity in Dengue & other Infectious Diseases

Recommended Readings:

Empirical Papers

Parameswaran, P., Charlebois, P., Tellez, Y., Nunez, A., Ryan, E. M., Malboeuf, C. M., … Henn, M. R. (2012). Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity. Journal of Virology, 86(16), 8546–8558. doi:10.1128/JVI.00736-12

Parameswaran, P., Liu, Y., Roskin, K. M., Jackson, K. K. L., Dixit, V. P., Lee, J.-Y., … Fire, A. Z. (2013). Convergent antibody signatures in human dengue. Cell Host & Microbe, 13(6), 691–700. doi:10.1016/j.chom.2013.05.008

Parameswaran, P., Sklan, E., Wilkins, C., Burgon, T., Samuel, M. a, Lu, R., … Fire, A. Z. (2010). Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS pathogens, 6(2), e1000764. doi:10.1371/journal.ppat.1000764

Review Articles

Fontana, J. M., Alexander, E., & Salvatore, M. (2012). Translational research in infectious disease: current paradigms and challenges ahead. Translational Research, 159(6), 430–453. doi:10.1016/j.trsl.2011.12.009

Wylie, K. M., Weinstock, G. M., & Storch, G. a. (2012). Emerging view of the human virome. Translational Research, 160(4), 283–290. doi:10.1016/j.trsl.2012.03.006

Recommended Readings: Peter Palese, Ph.D.

Friday Lecture Series

Toward a Universal Influenza Virus Vaccine

Peter Palese, Ph.D., Horace W. Goldsmith Professor and chair,

department of microbiology,

Mount Sinai School of Medicine

 February 1, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Bouvier, N. M. and P. Palese. 2008. “The Biology of Influenza Viruses.” Vaccine 26 (SUPPL. 4): D49-D53

Hai, R., A. García-Sastre, D. E. Swayne, and P. Palese. 2011. “A Reassortment-Incompetent Live Attenuated Influenza Virus Vaccine for Protection Against Pandemic Virus Strains.” Journal of Virology 85 (14): 6832-6843

Kashyap, A. K., J. Steel, A. F. Oner, M. A. Dillon, R. E. Swale, K. M. Wall, K. J. Perry, et al. 2008. “Combinatorial Antibody Libraries from Survivors of the Turkish H5N1 Avian Influenza Outbreak Reveal Virus Neutralization Strategies.” Proceedings of the National Academy of Sciences of the United States of America 105 (16): 5986-5991

Medina, R. A., B. Manicassamy, S. Stertz, C. W. Seibert, R. Hai, R. B. Belshe, S. E. Frey, C. F. Basler, P. Palese, and A. Garcí-Sastre. 2010. “Pandemic 2009 H1N1 Vaccine Protects Against 1918 Spanish Influenza Virus.” Nature Communications 1 (3)

Wang, T. T. and P. Palese. 2011. “Catching a Moving Target.” Science 333 (6044): 834-835

Wang, T. T., G. S. Tan, R. Hai, N. Pica, L. Ngai, D. C. Ekiert, I. A. Wilson, A. García-Sastre, T. M. Moran, and P. Palese. 2010. “Vaccination with a Synthetic Peptide from the Influenza Virus Hemagglutinin Provides Protection Against Distinct Viral Subtypes.” Proceedings of the National Academy of Sciences of the United States of America 107 (44): 18979-18984


Recommended Readings: Beatrice H. Hahn, M.D.

Friday Lecture Series

Maclyn McCarty Memorial Lecture

Great Ape Reservoirs of Human AIDS and Malaria

Beatrice H. Hahn, M.D., professor, departments of medicine and microbiology,

University of Pennsylvania

 January 25, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Keele, B. F., J. H. Jones, K. A. Terio, J. D. Estes, R. S. Rudicell, M. L. Wilson, Y. Li, et al. 2009. “Increased Mortality and AIDS-Like Immunopathology in Wild Chimpanzees Infected with SIVcpz.” Nature 460 (7254): 515-519

Lee, H. Y., E. E. Giorgi, B. F. Keele, B. Gaschen, G. S. Athreya, J. F. Salazar-Gonzalez, K. T. Pham, et al. 2009. “Modeling Sequence Evolution in Acute HIV-1 Infection.” Journal of Theoretical Biology 261 (2): 341-360

Liu, J., B. F. Keele, H. Li, S. Keating, P. J. Norris, A. Carville, K. G. Mansfield, et al. 2010. “Low-Dose Mucosal Simian Immunodeficiency Virus Infection Restricts Early Replication Kinetics and Transmitted Virus Variants in Rhesus Monkeys.” Journal of Virology 84 (19): 10406-10412

Liu, W., Y. Li, G. H. Learn, R. S. Rudicell, J. D. Robertson, B. F. Keele, J. -B N. Ndjango, et al. 2010. “Origin of the Human Malaria Parasite Plasmodium Falciparum in Gorillas.” Nature 467 (7314): 420-425

Rayner, J. C., W. Liu, M. Peeters, P. M. Sharp, and B. H. Hahn. 2011. “A Plethora of Plasmodium Species in Wild Apes: A Source of Human Infection?” Trends in Parasitology 27 (5): 222-229

Sharp, P. M. and B. H. Hahn. 2010. “The Evolution of HIV-1 and the Origin of AIDS.” Philosophical Transactions of the Royal Society B: Biological Sciences 365 (1552): 2487-2494


Recommended Readings: Bruce Walker, M.D.

Friday Lecture Series

Immune Control and Immune Failure in HIV Infection

Bruce Walker, M.D., Principal Investigator,

Ragon Institute of MGH, MIT and Harvard

April 13, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium


Recommended Readings:

Huang, J., P. S. Burke, T. D. H. Cung, F. Pereyra, I. Toth, B. D. Walker, L. Borges, M. Lichterfeld, and X. G. Yu. 2010. “Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers.” Journal of Virology 84 (18): 9463-9471

Kawashima, Y., K. Pfafferott, J. Frater, P. Matthews, R. Payne, M. Addo, H. Gatanaga, et al. 2009. “Adaptation of HIV-1 to Human Leukocyte Antigen Class I.” Nature 458 (7238): 641-645

Mahalanabis, M., P. Jayaraman, T. Miura, F. Pereyra, E. M. Chester, B. Richardson, B. Walker, and N. L. Haigwood. 2009. “Continuous Viral Escape and Selection by Autologous Neutralizing Antibodies in Drug-Naïve Human Immunodeficiency Virus Controllers.” Journal of Virology 83 (2): 662-672

Matthews, P. C., A. Prendergast, A. Leslie, H. Crawford, R. Payne, C. Rousseau, M. Rolland, et al. 2008. “Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point.” Journal of Virology 82 (17): 8548-8559

Pereyra, F., S. Palmer, T. Miura, B. L. Block, A. Wiegand, A. C. Rothchild, B. Baker, et al. 2009. “Persistent Low-Level Viremia in HIV-1 Elite Controllers and Relationship to Immunologic Parameters.” Journal of Infectious Diseases 200 (6): 984-990

Virgin, H. W. and B. D. Walker. 2010. “Immunology and the Elusive AIDS Vaccine.” Nature 464 (7286): 224-231

Viruses: We’ve Barely Begun To Know Them

Though viruses are the most abundant life form on Earth, our knowledge of the viral universe is limited to a tiny fraction of the viruses that likely exist.  An international team of researchers from the University of Pittsburgh, Washington University in St. Louis, and the University of Barcelona have found that raw sewage is home to thousands of novel, undiscovered viruses, some of which could relate to human health.  Read more about developing new techniques to look for novel viruses in unique places around the world.