Recommended Readings: Howard C. Hang, Ph.D. Friday October 19, 2018

Friday Lectures

Friday, October 19, 2018  3:45 p.m.

Caspary Auditorium

Howard C. Hang Ph.D.

Richard E. Salomon Family Associate Professor and Head

Laboratory of Chemical Biology and Microbial Pathogenesis

The Rockefeller University

Chemical Dissection of Host-Microbe Interactions

Recommended Readings:

Empirical Articles

Liu W, Zhou Y, Peng T, Zhou P, Ding X, Li Z, Zhong H, Xu Y, Chen S, Hang HC, Shao F. (2018). Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. NATURE MICROBIOLOGY. 3 (9): 996-1009

Thinon, Emmanuelle; Fernandez, Joseph P.; Molina, Henrik; et al. (2018). Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. JOURNAL OF PROTEOME RESEARCH. 17 (5): 1907-1922

Westcott N, Fernandez JP, Molina H, Hang HC. (2017). Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress. NATURE CHEMICAL BIOLOGY. 13 (3): 302-308

Peng T, Hang HC. (2016). Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 138 (43): 14423-14433

Rangan, Kavita J.; Pedicord, Virginia A.; Wang, Yen-Chih; et al. (2016). A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. SCIENCE. 353 (6306): 1434-1437

Percher, Avital; Ramakrishnan, Srinivasan; Thinon, Emmanuelle; et al. (2016). Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation. PNAS. 113 (16): 4302-7

Review Paper

Peng, Tao; Thinon, Emmanuelle; Hang, Howard C. (2016). Proteomic analysis of fatty-acylated proteins. CURRENT OPINION IN CHEMICAL BIOLOGY. 30: 77-86

Westcott, Nathan P.; Hang, Howard C. (2014). Chemical reporters for exploring ADP-ribosylation and AMPylation at the host-pathogen interface.  CURRENT OPINION IN CHEMICAL BIOLOGY. 23: 56-62

Grammel, Markus; Hang, Howard C. (2013). Chemical reporters for biological discovery. NATURE CHEMICAL BIOLOGY. 9 (8): 475-484

Recommended Readings: Peter Reddien, Ph.D. Friday September 28, 2018

Friday Lectures

Friday, September 28, 2018  3:45 p.m.

Caspary Auditorium

Peter Reddien Ph.D.

Professor and Associate Department Head

Department of Biology

Massachusetts Institute of Technology

How Stem Cells and Positional Information Lead to Planarian Regeneration

Recommended Readings:

Science News

Lisa Girard. A blueprint for regeneration. March 15, 2018. MIT News

Empirical Articles

Fincher, Christopher T.; Wurtzel, Omri; de Hoog, Thom; et al. (2018). Cell type transcriptome atlas for the planarian Schmidtea mediterranea. SCIENCE.  360 (6391): 874-+

Atabay KD, LoCascio SA, de Hoog T, Reddien PW. (2018). Self-organization and progenitor targeting generate stable patterns in planarian regeneration. SCIENCE. 360 (6387):404-409

Scimone, M. Lucila; Cote, Lauren E.; Reddien, Peter W. (2017). Orthogonal muscle fibres have different instructive roles in planarian regeneration. NATURE. 551 (7682): 623-+  

Raz, Amelie A.; Srivastava, Mansi; Salvamoser, Ranja; et al. (2017). Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning. NATURE COMMUNCATIONS. 8

Wurtzel, Omri; Oderberg, Isaac M.; Reddien, Peter W. (2017). Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity. DEVELOPMENTAL CELL. 40 (5): 491-504  

Scimone, M. Lucila; Kravarik, Kellie M.; Lapan, Sylvain W.; et al. (2014). Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea. STEM CELLS REPORTS. 3 (2): 339-352

van Wolfswinkel, Josien C.; Wagner, Daniel E.; Reddien, Peter W. (2014). Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment. CELL STEM CELL. 15 (3): 326-339

Wagner, Daniel E.; Wang, Irving E.; Reddien, Peter W. (2011). Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration. SCIENCE. 332 (6031): 811-816  

Review Paper

Tanaka, Elly M.; Reddien, Peter W. (2011). The Cellular Basis for Animal Regeneration. DEVELOPMENTAL CELL. 21 (1): 172-185

Reddien, Peter W. (2011). Constitutive gene expression and the specification of tissue identity in adult planarian biology.  TRENDS IN GENETICS. 27 (7): 277-285  

Book Chapter

Wang IE, Wagner DE, Reddien PW. (2018). Clonal Analysis of Planarian Stem Cells by Subtotal Irradiation and Single-Cell Transplantation. Planarian Regeneration. 1774:479-495

Recommended Readings: John Hardy, Ph.D. Friday September 7, 2018

Friday Lectures

Friday, September 7, 2018  3:45 p.m.

Caspary Auditorium

John Hardy Ph.D.

Head of the Department of Molecular Neuroscience

Chair of the Molecular Biology of Neurological Disease

University College London

Genomic Analysis of Alzheimer’s Disease and other Neurodegenerative Disorders

Recommended Readings:

Science News

Rebecca Hiscott. AT THE BENCH: John Hardy, PhD, on Unraveling the Genetics of Alzheimer’s Disease and Attending the ‘Oscars of Science’. January 7, 2016. Neurology Today

Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk. November 14, 2012. ALZFORUM

Empirical Articles

Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; et al. (2018). Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA NEUROLOGY. 75 (7)860-875 

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; et al. (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. NATURE GENETICS. 49 (9)1373-+ 

Wang, Yaming; Cella, Marina; Mallinson, Kaitlin; et al. (2015).TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model. CELL. 160 (6):1061-1071

Nalls, Mike A.; Pankratz, Nathan; Lill, Christina M.; et al. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. NATURE GENETICS. 46 (9)989-+

Guerreiro, Rita; Wojtas, Aleksandra; Bras, Jose; et al. (2013). TREM2 Variants in Alzheimer’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 368 (2): 355-358

Jones, Lesley; Holmans, Peter A.; Hamshere, Marian L.; et al. (2010). Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer’s Disease. PLOS ONE. 5 (11)

Hardy, JDuff, KHardy, KGPerez-Tur, JHutton, M(1998). Genetic dissection of Alzheimer’s disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1 (5): 355 – 358

Hardy JA, Higgins GA. (1992). Alzheimer’s disease: the amyloid cascade hypothesis. Science. 256 5054):184-5

Review Paper

Hardy, John. (2017). The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”. FEBS JOURNAL. 284 (7): 1040-1044

Selkoe, Dennis J.; Hardy, John. (2016). The amyloid hypothesis of Alzheimer’s disease at 25years. EMBO MOLECULAR MEDICINE. 8 (6)595-608

Hampel, Harald; Frank, Richard; Broich, Karl; et al. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. NATURE REVIEWS DRUG DISCOVERY. 9 (7)560-574

Book Chapter

Yu, Jin-Tai; Tan, Lan; Hardy, John. (2014). Apolipoprotein E in Alzheimer’s Disease: An Update. ANNUAL REVIEW OF NEUROSCIENCE. 3779-100

Hardy, John. (2012). Alzheimer’s disease and related dementias. NEUROGENETICS: A GUIDE FOR CLINICIANS. 17-31

Recommended Readings: David Pellman, M.D. Friday June 1, 2018

Friday Lectures

Friday, June 1, 2018  3:45 p.m.

Caspary Auditorium

David Pellman M.D.

Margaret M. Dyson Professor

Department of Cell Biology

Harvard Medical School

Mechanisms of Rapid Genome Evolution

Recommended Readings:

Science News

Dana-Farber Cancer Institute. Researchers identify origin of chromosomal oddity in some cancer cells. May 27, 2015. EurekAlert

Empirical Articles

Marteil, Gaelle; Guerrero, Adan; Vieira, Andre F.; et al. (2018). Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. NATURE COMMUNICATIONS. 9    

Zhang, Cheng-Zhong; Spektor, Alexander; Cornils, Hauke; et al. (2015). Chromothripsis from DNA damage in micronuclei. NATURE. 522 (7555): 179-+

Selmecki, Anna M.; Maruvka, Yosef E.; Richmond, Phillip A.; et al. (2015). Polyploidy can drive rapid adaptation in yeast. NATURE. 519 (7543): 349-+

Crasta, Karen; Ganem, Neil J.; Dagher, Regina; et al. (2012). DNA breaks and chromosome pulverization from errors in mitosis. NATURE. 482 (7383): 53-U70

Carter, Scott L.; Cibulskis, Kristian; Helman, Elena; et al. (2012). Absolute quantification of somatic DNA alterations in human cancer. NATURE BIOTECHNOLOGY. 30 (5): 413-+

Ganem, Neil J.; Godinho, Susana A.; Pellman, David. (2009). A mechanism linking extra centrosomes to chromosomal instability. NATURE. 460 (7252): 278-U146

Review Paper

Zhang, Cheng-Zhong; Leibowitz, Mitchell L.; Pellman, David. (2013). Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. GENES AND DEVELOPMENT. 27 (23): 2513-2530   

Gordon, David J.; Resio, Benjamin; Pellman, David. (2012). Causes and consequences of aneuploidy in cancer. NATURE REVIEWS GENETICS. 13 (3): 189-203

Book Chapter

Leibowitz, Mitchell L.; Zhang, Cheng-Zhong; Pellman, David. (2015). Chromothripsis: A New Mechanism for Rapid Karyotype Evolution. ANNUAL REVIEW OF GENETICS. 49: 183-211

Recommended Readings: Stephen Elledge, Ph.D. Friday May 18, 2018

Friday Lectures

Friday, May 18, 2018  3:45 p.m.

Caspary Auditorium

Stephen J. Elledge Ph.D.

Gregor Mendel Professor

Department of Genetics

Harvard Medical School

Microgenetics: What We Can Learn About Protein Degradation from Bits of Genes

Recommended Readings:

Science News

Your viral infection history in a single drop of blood. June 4, 2015. ScienceDaily

Empirical Articles

Sack, Laura Magill; Davoli, Teresa; Li, Mamie Z.; et al. (2018). Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. CELL. 173 (2): 499-+

Liao, Sida; Davoli, Teresa; Leng, Yumei; et al. (2017). A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. GENES AND DEVELOPMENT. 31 (2): 184-196

Xu, George J.; Kula, Tomasz; Xu, Qikai; et al. (2015). Comprehensive serological profiling of human populations using a synthetic human virome. SCIENCE. 348 (6239)

Emanuele, Michael J.; Elia, Andrew E. H.; Xu, Qikai; et al. (2011). Global Identification of Modular Cullin-RING Ligase Substrates. CELL. 147 (2): 459-474

Larman, H. Benjamin; Zhao, Zhenming; Laserson, Uri; et al. (2011). Autoantigen discovery with a synthetic human peptidome. NATURE BIOTECHNOLOGY. 29 (6): 535-U101

Yen, Hsueh-Chi Sherry; Xu, Qikai; Chou, Danny M.; et al. (2008). Global Protein Stability Profiling in Mammalian Cells. SCIENCE. 322 (5903): 918-923

Yen, Hsueh-Chi Sherry; Elledge, Stephen J. (2008). Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling. SCIENCE. 322 (5903): 923-929

Review Paper

Ciccia, Alberto; Elledge, Stephen J. (2010). The DNA Damage Response: Making It Safe to Play with Knives. MOLECULAR CELL. 40 (2): 179-204

Luo, Ji; Solimini, Nicole L.; Elledge, Stephen J. (2009). Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction. CELL. 136 (5): 823-837

 

Recommended Readings: Stephen Goff, Ph.D. Friday May 11, 2018

Friday Lectures

Friday, May 11, 2018  3:45 p.m.

Caspary Auditorium

Stephen Goff Ph.D.

Higgins Professor

Department of Biochemistry and Molecular Biophysics

Columbia University College of Physicians and Surgeons

Quiet, Please: Silencing Retroviral DNAs

Recommended Readings:

Empirical Articles

Lee, Andreia; CingOz, Oya; Sabo, Yosef; et al. (2018). Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. VIROLOGY. 516: 165-175

Geis, Franziska K.; Galla, Melanie; Hoffmann, Dirk; et al. (2017). Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. RETROVIROLOGY. 14

Wang, Gary Z.; Goff, Stephen P. (2017). Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells. JOURNAL OF VIROLOGY. 91 (1)

Wang, Cheng; Goff, Stephen P. (2017). Differential control of retrovirus silencing in embryonic cells by proteasomal regulation of the ZFP809 retroviral repressor. PNAS. 114 (6): E922-E930

Wang, Gary Z.; Wang, Ying; Goff, Stephen P. (2016). Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry. CELL HOST MICROBE.  20 (6): 798-809

Griffin, Daniel O.; Goff, Stephen P. (2015). HIV-1 Is Restricted prior to Integration of Viral DNA in Primary Cord-Derived Human CD34(+) Cells. JOURNAL OF VIROLOGY. 89 (15): 8096-8100

Yang, Bin Xia; El Farran, Chadi A.; Guo, Hong Chao; et al. (2015). Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. CELL. 163 (1): 230-245

Review Paper

Schlesinger, Sharon; Goff, Stephen P. (2015). Retroviral Transcriptional Regulation and Embryonic Stem Cells: War and Peace. MOLECULAR AND CELLULAR BIOLOGY. 35 (5): 770-777

Studamire, Barbara; Goff, Stephen P. (2010). Interactions of Host Proteins with the Murine Leukemia Virus Integrase. VIRUSES. 2 (5): 1110-1145


Recommended Readings: Beth Stevens, Ph.D. Friday May 4, 2018

Friday Lectures

Friday, May 4, 2018  3:45 p.m.

Caspary Auditorium

Beth Stevens Ph.D.

Associate Professor

Department of Neurology

Harvard Medical School – Boston Children’s Hospital

How the Immune System Sculpts Brain Circuitry

Recommended Readings:

Science News

Beth Stevens and Todd E. Golden. Deciphering neurodegeneration: Inflammation, immune response, and Alzheimer’s. (Webinar – February 7, 2018). Science

Empirical Articles

Shi, Qiaoqiao; Chowdhury, Saba; Ma, Rong; et al. (2017). Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. SCIENCE TRANSLATIONAL MEDICINE. 9 (392)

Hong, Soyon; Beja-Glasser, Victoria F.; Nfonoyim, Bianca M.; et al. (2016). Complement and microglia mediate early synapse loss in Alzheimer mouse models. SCIENCE. 352 (6286): 712-716

Vasek, Michael J.; Garber, Charise; Dorsey, Denise; et al. (2016). A complement-microglial axis drives synapse loss during virus-induced memory impairment. NATURE. 534 (7608): 538-+

Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; et al. (2016). Schizophrenia risk from complex variation of complement component 4. NATURE. 530 (7589): 177-+

Schafer, Dorothy P.; Lehrman, Emily K.; Heller, Christopher T.; et al. (2014). An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 88

Schafer, Dorothy P.; Lehrman, Emily K.; Kautzman, Amanda G.; et al. (2012). Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner. NEURON. 74 (4): 691-705

Review Paper

Salter, Michael W.; Stevens, Beth. (2017). Microglia emerge as central players in brain disease. NATURE MEDICINE. 23 (9): 1018-1027

Hong, Soyon; Dissing-Olesen, Lasse; Stevens, Beth. (2016). New insights on the role of microglia in synaptic pruning in health and disease. CURRENT OPINION IN NEUROBIOLOGY. 36: 128-134  

Bilimoria, Parizad M.; Stevens, Beth. (2015). Microglia function during brain development: New insights from animal models. BRAIN RESEARCH. 1617: 7-17  

Book Chapter

Stephan, Alexander H.; Barres, Ben A.; Stevens, Beth. (2012). The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease.  ANNUAL REVIEW OF NEUROSCIENCE. 35: 369-389

Recommended Readings: David Reich, Ph.D. Friday April 27, 2018

Friday Lectures

Friday, April 27, 2018  3:45 p.m.

Caspary Auditorium

David Reich Ph.D.

Professor

Department of Genetics

Harvard Medical School

Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past

Recommended Readings:

Science News

Jared Diamond. A Brand-New Version of Our Origin Story. (April 20, 2018). The New York Times

Robin McKie. Neanderthals were perhaps capable of many modern human behaviours. (April 7, 2018). The Guardian

Turi King. Sex, power and ancient DNA. (March 13, 2018). Nature

Empirical Articles

Loreille, Odile ; Ratnayake, Shashikala ; Bazinet, Adam L.; et al. (2018). Biological Sexing of a 4000-Year-Old Egyptian Mummy Head to Assess the Potential of Nuclear DNA Recovery from the Most Damaged and Limited Forensic Specimens. GENES. 9 (3): 135

Olalde, Inigo; Brace, Selina; Allentoft, Morten E.; et al. (2018). The Beaker phenomenon and the genomic transformation of northwest Europe. NATURE. 555 (7695): 190-196

Mathieson, Iain; Alpaslan-Roodenberg, Songul; Posth, Cosimo; et al. (2018). The genomic history of southeastern Europe. NATURE. 555 (7695): 197-203

Hajdinjak, Mateja; Fu, Qiaomei; Huebner, Alexander; et al. (2018). Reconstructing the genetic history of late Neanderthals. NATURE. 555 (7698): 652-656

Lipson, Mark; Skoglund, Pontus; Spriggs, Matthew; et al. (2018). Population Turnover in Remote Oceania Shortly after Initial Settlement. CURRENT BIOLOGY. 28 (7): 1157-+

Palkopoulou, Eleftheria; Lipson, Mark; Mallick, Swapan; et al. (2018). A comprehensive genomic history of extinct and living elephants. PNAS. 115 (11): E2566-E2574

Tassi, Francesca; Vai, Stefania; Ghirotto, Silvia; et al. (2017). Genome diversity in the Neolithic Globular Amphorae culture and the spread of Indo-European languages. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 284 (1867

Haak, Wolfgang; Lazaridis, Iosif; Patterson, Nick; et al. (2015). Massive migration from the steppe was a source for Indo-European languages in Europe. NATURE. 522 (7555): 207-+

Altshuler, David M.; Durbin, Richard M.; Abecasis, Goncalo R.; et al. (2012). An integrated map of genetic variation from 1,092 human genomes. NATURE. 491 (7422): 56-65

Review Paper

Pickrell, Joseph K.; Reich, David. (2014). Toward a new history and geography of human genes informed by ancient DNA. TRENDS IN GENETICS.  30 (9): 377-389

Book

David Reich, Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past (Pantheon Books, New York, and Oxford University Press, Oxford, 2018)

Recommended Readings: Clare Waterman, Ph.D. Friday April 6, 2018

Friday Lectures

Friday, April 6, 2018  3:45 p.m.

Caspary Auditorium

Clare Waterman Ph.D.

NIH Distinguished Investigator

Laboratory of Cell and Tissue Morphodynamics

National Institutes of Health

Integrating Actin Dynamics and Adhesion in Cell Migration and Immune Function

Recommended Readings:

Science News

Live-Cell Microscopy Reveals How Cell Movement is Driven. Dec 11, 2017. GEN News

Empirical Articles

Nordenfelt, Pontus; Moore, Travis I.; Mehta, Shalin B.; et al. (2017). Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration. NATURE COMMUNCATIONS. 8

Swaminathan, Vinay; Kalappurakkal, Joseph Mathew; Mehta, Shalin B.; et al. (2017). Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions. PNAS. 114 (40): 10648-10653

Wu, Yicong; Chandris, Panagiotis; Winter, Peter W.; et al. (2016). Simultaneous multiview capture and fusion improves spatial resolution in wide-field and light-sheet microscopy. OPTICA. 3 (8): 897-910

Plotnikov, Sergey V.; Pasapera, Ana M.; Sabass, Benedikt; et al. (2012). Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration. CELL. 151 (7): 1513-1527

Kanchanawong, Pakorn; Shtengel, Gleb; Pasapera, Ana M.; et al. (2010). Nanoscale architecture of integrin-based cell adhesions. NATURE. 468 (7323): 580-U262

Review Paper

Case, Lindsay B.; Waterman, Clare M. (2015). Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch. NATURE CELL BIOLOGY. 17 (8): 955-963

Fischer, Robert S.; Wu, Yicong; Kanchanawong, Pakorn; et al. (2011). Microscopy in 3D: a biologist’s toolbox. TRENDS IN CELL BIOLOGY. 21 (12): 682-691

Book Chapter

Skau, Colleen T.; Waterman, Clare M. (2015). Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors. ANNUAL REVIEW OF BIOPHYSICS. 44: 285-310

Gardel, Margaret L.; Schneider, Ian C.; Aratyn-Schaus, Yvonne; et al. (2010). Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 26: 315-333

Recommended Readings: Christopher D. Lima, Ph.D. Friday March 30th, 2018

Friday Lectures

Friday, March 30th, 2018  3:45 p.m.

Caspary Auditorium

Christopher D. Lima, Ph.D.

Professor

Structural Biology Program

Memorial Sloan Kettering Cancer Center

Targeting RNA for Degradation by the Eukaryotic RNA Exosome

Recommended Readings:

Empirical Articles

Wasmuth, Elizabeth V.; Lima, Christopher D. (2017). The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome. NUCLEIC ACIDS RESEARCH. 45 (2): 846-860

Januszyk, Kurt; Lima, Christopher D. (2014). The eukaryotic RNA exosome. CURRENT OPINION IN STRUCTURAL BIOLOGY. 24: 132-140

Zinder, John C.; Wasmuth, Elizabeth V.; Lima, Christopher D. (2016). Nuclear RNA Exosome at 3.1 angstrom Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3. MOLECULAR CELL. 64 (4): 734-745

Wasmuth, Elizabeth V.; Januszyk, Kurt; Lima, Christopher D. (2014). Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. NATURE. 511 (7510): 435-+

Wasmuth, Elizabeth V.; Lima, Christopher D. (2012). Exo- and Endoribonucleolytic Activities of Yeast Cytoplasmic and Nuclear RNA Exosomes Are Dependent on the Noncatalytic Core and Central Channel. MOLECULAR CELL. 48 (1): 133-144

Liu, Quansheng; Greimann, Jaclyn C.; Lima, Christopher D. (2006). Reconstitution, activities, and structure of the eukaryotic RNA exosome. CELL. 127 (6): 1223-1237

Review Paper

Zinder, John C.; Lima, Christopher D. (2017). Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors. GENES & DEVELOPMENT. 31 (2): 88-100

Book Chapter

Greimann, Jaclyn C.; Lima, Christopher D. (2008). RECONSTITUTION of RNA Exsomes From Human And Saccharomyces Cerevisiae: Clonning, Expression, Purification, And  Activity Assays. METHODS IN ENZYMOLOGY. 448: 185-210