Recommended Readings: Jeffrey M. Friedman, M.D., Ph.D.

Friday Lectures

Friday, February 24, 2017   3:45 p.m.

Caspary Auditorium

Jeffrey M. Friedman,  M.D., Ph.D.

Marilyn M. Simpson Professor and Head,

Laboratory of Molecular Genetics

The Rockefeller University

Leptin Physiology, Pathophysiology and

the Neural Circuit Regulating Body Weight


Recommended Readings:

Friedman, Jeffrey (2016). The long road to leptin. JOURNAL OF CLINICAL INVESTIGATION. 126(12): 4727-4734

Friedman, Jeffrey M.; Mantzoros, Christos S. (2015). 20 years of leptin: From the discovery of the leptin gene to leptin in our therapeutic armamentarium. METABOLISM-CLINICAL AND EXPERIMENTAL. 64(1): 1-4   PLEASE REQUEST FROM MARKUS LIBRARY

Bouret, Sebastien G.; Bates, Sarah H.; Chen, Stephen; et al. (2012). Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits. JOURNAL OF NEUROSCIENCE. 32(4): 1244-1252

Domingos, Ana I.; Vaynshteyn, Jake; Voss, Henning U.; et al. (2011). Leptin regulates the reward value of nutrient. NATURE NEUROSCIENCE. 14(12): 1562-U92

Davis, Jon F.; Choi, Derrick L.; Schurdak, Jennifer D.; et al. (2011). Leptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits BIOLOGICAL PSYCHIATRY. 69(7): 668-674

Mantzoros, Christos S.; Magkos, Faidon; Brinkoetter, Mary; et al. (2011). Leptin in human physiology and pathophysiology.  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 301(4): E567-E584

Wang, May-yun; Chen, Lijun; Clark, Gregory O.; et al. (2010). Leptin therapy in insulin-deficient type I diabetes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(11): 4813-4819

Oral, EA; Simha, V; Ruiz, E; et al. (2002). Leptin-replacement therapy for lipodystrophy. NEW ENGLAND JOURNAL OF MEDICINE. 346(8): 570-578



Recommended Readings: Edward S. Boyden Ph.D. Friday February 17, 2017

Friday Lectures

Friday, February 17, 2017   3:45 p.m.

Caspary Auditorium

Edward S. Boyden,  Ph.D.

Associate Professor

MIT Media Lab

Optical Tools for Analyzing and Repairing

Complex Biological Systems

Recommended Readings:

Boyden, Edward S. (2015). Optogenetics and the future of neuroscience. NATURE NEUROSCIENCE. 18(12): 1862-1862

Chen, Fei; Tillberg, Paul W.; Boyden, Edward S. (2015). Expansion microscopy. SCIENCE. 347(6221): 543-548   

Madisen, Linda; Mao, Tianyi; Koch, Henner; et al. (2012). A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. NATURE NEUROSCIENCE. 15(5): 793-802

Bernstein, Jacob G.; Garrity, Paul A.; Boyden, Edward S.  (2012). Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits. CURRENT OPINION IN NEUROBIOLOGY.   22(1): 61-71



Recommended Readings: Ian A. Wilson D. Phil., D. Sci., Friday February 10, 2017

Friday Lectures

Friday, February 10, 2017   3:45 p.m.

Caspary Auditorium

Ian A. Wilson  D. Phil., D.Sci.

Hansen Professor of Structural Biology, and

Chair, Dept. of Integrative Structural and Computational Biology

The Scripps Research Institute

Broad Neutralization of Influenza Viruses and

Implications for a Universal Vaccine and Therapy

Recommended Readings:

Dreyfus, Cyrille; Laursen, Nick S.; Kwaks, Ted; et al.  (2012). Highly Conserved Protective Epitopes on Influenza B Viruses.  SCIENCE, 337(6100): 1343-1348 

Walker, Laura M.; Huber, Michael; Doores, Katie J.; et al. (2011).  Broad neutralization coverage of HIV by multiple highly potent antibodiesNATURE , 477(7365): 466-U117

Ekiert, Damian C.; Friesen, Robert H. E.; Bhabha, Gira; et al. (2011).  A Highly Conserved Neutralizing Epitope on Group 2 Influenza A VirusesSCIENCE,  333(6044): 843-850 

Gottlieb, Tanya; Ben-Yedidia, Tamar.  (2014)  Epitope-based approaches to a universal influenza vaccine.  JOURNAL OF AUTOIMMUNITY.  54 (Special Issue: SI ):15-20 

He, Fang; Prabakaran, Mookkan; Kumar, Subaschandrabose Rajesh; et al. (2011), Monovalent H5 vaccine based on epitope-chimeric HA provides broad cross-clade protection against variant H5N1 viruses in miceANTIVIRAL RESEARCH,  105: 143-151 

Li, Zhuo; Gabbard, Jon D.; Mooney, Alaina; et al. (2013). Single-Dose Vaccination of a Recombinant Parainfluenza Virus 5 Expressing NP from H5N1 Virus Provides Broad Immunity against Influenza A Viruses.  JOURNAL OF VIROLOGY,  87(10): 5985-5993

Huber, Victor C.; Thomas, Paul G.; McCullers, Jonathan A. (2009).  A multi-valent vaccine approach that elicits broad immunity within an influenza subtypeVACCINE,  27(8): 1192-1200

Recommended Readings: Maria Barna Ph.D. Friday December 9, 2016

Friday Lectures

Friday, December 9, 2016   3:45 p.m.

Caspary Auditorium

Maria Barna, Ph.D.

Assistant Professor,

Departments of Developmental Biology and Genetics at Stanford University

Specialized Ribosomes:

A New Frontier in Gene Regulation, Organismal Biology, & Evolution

Recommended Readings:

Xue, Shifeng; Barna, Maria.   Specialized ribosomes: a new frontier in gene regulation and organismal biology.  NATURE REVIEWS MOLECULAR CELL BIOLOGY    13( 6):355-369     JUN 2012

Amunts, Alexey; Brown, Alan; Bai, Xiao-chen; et al.  Structure of the Yeast Mitochondrial Large Ribosomal Subunit.  SCIENCE   343(6178):1485-1489      MAR 28 2014

Xue, Shifeng; Tian, Siqi; Fujii, Kotaro; et al.  RNA regulons in Hox 5 ‘ UTRs confer ribosome specificity to gene regulation. NATURE   517(7532):33-U55   JAN 1 2015

Wu, XQ; Iyengar, P; RajBhandary, UL.   Ribosome-initiator tRNA complex as an intermediate in translation initiation in Escherichia coli revealed by use of mutant initiator tRNAs and specialized ribosomes. EMBO JOURNAL    15(17):4734-4739  SEP 2 1996

Shi, Zhen; Barna, Maria   Trransiating the Genome in Time and Space: Specialized Ribosomes, RNA. Regulons, and RNA-Binding Proteins. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31   Book Series: Annual Review of Cell and Developmental Biology   V. 31: 31-+    2015

Yadav, Anupama; Radhakrishnan, Aparna; Panda, Anshuman; et al. The Modular Adaptive Ribosome.   PLOS ONE   11(11): Article Number: e0166021    NOV 3 2016


Recommended Readings: Tania Baker Ph.D. Friday, November 18, 2016

Friday Lectures

Friday, November 18, 2016   3:45 p.m.

Caspary Auditorium

Tania Baker, Ph.D.

Edwin C. Whitehead Professor of Biology, MIT

Investigator, HHMI

Operations of AAA+ Unfoldase Motors:

Powerful Destroyers and Activators of Protein Function

Selected Publications:

Baker, Tania A.; Sauer, Robert T.  ClpXP, an ATP-powered unfolding and protein-degradation machine.    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH.   1823(Special Issue SI): 15-28     JAN 2012

Stinson, Benjamin M.; Nager, Andrew R.; Glynn, Steven E.; et al.  Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA plus Machine. CELL   153(3):628-639    APR 25 2013

Glynn, Steven E.; Nager, Andrew R.; Baker, Tania A.; et al.   Dynamic and static components power unfolding in topologically closed rings of a AAA plus proteolytic machine.   NATURE STRUCTURAL & MOLECULAR BIOLOGY.  19(6):616-+   JUN 2012

Cordova, Juan Carlos; Olivares, Adrian O.; Shin, Yongdae; et al.    Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine.  CELL    158(3): 647-658     JUL 31 2014

Olivares, Adrian O.; Nager, Andrew R.; Iosefson, Ohad; et al.   Mechanochemical basis of protein degradation by a double-ring AAA plus machine.   NATURE STRUCTURAL & MOLECULAR BIOLOGY    21(10): 871-875    OCT 2014


Recommended Readings: Eric N. Olson Ph.D. Friday December 2, 2016

Friday Lecture Series

 December 2, 2016

3:45 p.m. (refreshments 3:15)  Caspary Auditorium

Eric N. Olson, Ph.D.

Founding Chair, Department of Molecular Biology.

University of Texas Southwestern Medical Center

The Molecules and Mechanisms of Muscle Development,

Disease and Regeneration

Recommended Readings:

Shadrin, I. Y.; Khodabukus, A.; Bursac, N.   Striated muscle function, regeneration, and repair.  CELLULAR AND MOLECULAR LIFE SCIENCES.    73(22):4175-4202   NOV 2016

McCullagh, Karl J. A.; Perlingeiro, Rita C. R.  Coaxing stem cells for skeletal muscle repair.  ADVANCED DRUG DELIVERY REVIEWS    84: 198-207   APR 2015  REQUEST FROM MARKUS LIBRARY

Juhas, Mark; Bursac, Nenad   Engineering skeletal muscle repair.  CURRENT OPINION IN BIOTECHNOLOGY    24(5): 880-886    OCT 2013

Garbern, Jessica C.; Lee, Richard T.    Cardiac Stem Cell Therapy and the Promise of Heart Regeneration.  CELL STEM CELL  12(6): 689-698   JUN 6 2013 

Xin, Mei; Olson, Eric N.; Bassel-Duby, Rhonda   Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.  NATURE REVIEWS MOLECULAR CELL BIOLOGY     14(8): 529-541    AUG 2013

Nicklas, Sarah; Otto, Anthony; Wu, Xiaoli; et al.   TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration.  PLOS ONE   7 (1): e30445    JAN 27 2012  

Recommended Readings: Jennifer A. Zallen Ph.D. Friday November 11, 2016

Friday Lectures

Frfday, November 11, 2016   3:45 p.m.

Caspary Auditorium

Jennifer A. Zallen, Ph.D.

HHMI Investigator / Member, Sloan Kettering Institute

Signals and Forces that Control Multicellular

Organization in the Embryo

Recommended Readings:

Mao, Qiyan; Lecuit, Thomas    Mechanochemical Interplay Drives Polarization in Cellular and Developmental Systems.  Book Series: Current Topics in Developmental Biology   Volume:116   Pages: 633-+    2016   Edited by: Wassarman, PM

Gouti, Mina; Metzis, Vicki; Briscoe, James.  The route to spinal cord cell types: a tale of signals and switches.TRENDS IN GENETICS   31(6): 282-289   Published: JUN 2015

Uriu, Koichiro; Morelli, Luis G.; Oates, Andrew C.  Interplay between intercellular signaling and cell movement in development.  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY    35: 66-72      NOV 2014

Neijts, Roel; Simmini, Salvatore; Giuliani, Fabrizio; et al   Region-Specific Regulation of Posterior Axial Elongation During Vertebrate Embryogenesis.  DEVELOPMENTAL DYNAMICS   243(1. Special Issue: SI): 88-98    JAN 2014

 Zallen, Jennifer A.; Blankenship, J. Todd   Multicellular dynamics during epithelial elongation.  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY.   19(3): 263-270 : JUN 2008

Recommended Readings: Nicole King Ph.D. October 7 2016

Friday Lecture Series

Friday October 7, 2016   3:45 p.m.

The Fairfield Osborn Memorial Lecture

Caspary Auditorium

Nicole King

Professor, and HHMI Investigator

Dept.of Molecular and Cell Biology, Division of Genetics, Genomics and Development

University of California Berkeley

Bacteria as Master Regulators and Aphrodisiacs

Recommended Readings:

Anderson, Douglas P.; Whitney, Dustin S.; Hanson-Smith, Victor; et al.  Evolution of an ancient protein function involved in organized multicellularity in animals. ELIFE                   5: e10147    JAN 7 2016

Alegado, Rosanna A.; King, Nicole  Bacterial Influences on Animal OriginsCOLD SPRING HARBOR PERSPECTIVES IN BIOLOGY    6(11): a016162  NOV 2014

King, Nicole.  Evolutionary Transitions to Multicellular Life Principles and Mechanisms Forrward.  EVOLUTIONARY TRANSITIONS TO MULTICELLULAR LIFE: PRINCIPLES AND MECHANISMS   Book Series:Advances in Marine Genomics   Volume: 2   Pages: V-VI    2015

King, Nicole; Mueller, Susann.  Environmental microbiology: Revisiting the physiology of microorganisms on the single cell scale. CURRENT OPINION IN MICROBIOLOGY     Volume: 25   Pages: V-VI   Published: JUN 2015

Recommended Readings: Uri Alon Ph.D. October 28 2016

Friday Lecture Series

Friday  October 28  2016    3:45  p.m.

Caspary Auditorium

Uri Alon

Professor, Department of Molecular Cell Biology

Weizmann Institute of Science

Evolutionary Trade Offs and the Geometry of Phenotype Space

Recommended Readings:

Keren, Leeat; Hausser, Jean; Lotan-Pompan, Maya; et al. Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness. CELL    166(5):1282-+  AUG 25 2016

Korem, Yael; Szekely, Pablo; Hart, Yuval; et al. Geometry of the Gene Expression Space of Individual Cells. PLOS COMPUTATIONAL BIOLOGY    11(7):e1004224   JUL 2015

Tendler, Avichai; Mayo, Avraham; Alon, Uri  Evolutionary tradeoffs, Pareto optimality and the morphology of ammonite shells. BMC SYSTEMS BIOLOGY  V 9: article number: 12   MAR 7 2015

Szekely, Pablo; Sheftel, Hila; Mayo, Avi; et al. Evolutionary Tradeoffs between Economy and Effectiveness in Biological Homeostasis Systems.  PLOS COMPUTATIONAL BIOLOGY.   9(8): e1003163    AUG 2013

Sheftel, Hila; Shoval, Oren; Mayo, Avi; et al. The geometry of the Pareto front in biological phenotype space. ECOLOGY AND EVOLUTION.   3(6):1471-1483    JUN 2013

Recommended Readings: Rebecca Saxe Ph.D. October 21, 2016

Friday Lecture Series

Friday October 21, 2016   3:45 p.m.

Caspary Auditorium

Rebecca Saxe, Ph.D.

Professor, MIT, Brain and Cognitive Sciences

It’s the Thought that counts: Progress in understanding the 

Neural basis of Theory of Mind

Recommended Readings:

 Chakroff, Alek; Dungan, James; Koster-Hale, Jorie; et al.  When minds matter for moral judgment: intent information is neurally encoded for harmful but not impure acts. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE   11(3):476-484    MARCH 2016

Jacoby, Nir; Bruneau, Emile; Koster-Hale, Jorie; et al.  Localizing Pain Matrix and Theory of Mind networks with both verbal and non-verbal stimuli. NEUROIMAGE  126:39-48     FEB 1 2016

Deen, Ben; Koldewyn, Kami; Kanwisher, Nancy; et al.  Functional Organization of Social Perception and Cognition in the Superior Temporal Sulcus. CEREBRAL CORTEX    25(11):4596-4609     NOV 2015

Bruneau, Emile G.; Cikara, Mina; Saxe, Rebecca.  Minding the Gap: Narrative Descriptions about Mental States Attenuate Parochial Empathy.  PLOS ONE                 10:e0140838     OCT 27 2015

Andrews-Hanna, Jessica R.; Saxe, Rebecca; Yarkoni, Tal   Contributions of episodic retrieval and mentalizing to autobiographical thought: Evidence from functional neuroimaging, resting-state connectivity, and fMRI meta-analyses. NEUROIMAGE   91:324-335   MAY 1 2014

Koster-Hale, Jorie; Saxe, Rebecca; Dungan, James; et al.  Decoding moral judgments from neural representations of intentions. PNAS   110(14): 5648-5653   APRIL 2 2013