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Elsevier Offers Free Access to 2012 Nobel Laureates Most Cited Papers

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Elsevier congratulates the 2012 Nobel Laureates and is proud to honor their revolutionary research in the fields of Medicine, Physics, Chemistry and Economics.  All eight Nobel scientists have connections with Elsevier, publishing journal articles and book chapters and serving as journal editors or members of editorial boards.  In recognition of these extraordinary scholars and their contributions to science, we are pleased to provide free access on ScienceDirect to their most-cited ground-breaking research published in Elsevier journals.

Dr. John Gurdon and Dr. Shinya Yamanaka share the award in physiology or medicine for discovering that mature, specialized cells can be reprogrammed into immature cells capable of developing into all tissues of the body. Their key individual research findings into so-called stem cells were separated by 50 years.

 

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Recommended Readings: Laurie Glimcher, M.D.

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Friday Lecture Series

Close to the Bone: Novel Genes that Remodel the Skeleton

Laurie Glimcher, M.D., Stephen and Suzanne Weiss Dean,

Weill Cornell Medical College

 November 9, 2012

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings

Greenblatt, M. B., Shim, J. -., Zou, W., Sitara, D., Schweitzer, M., Hu, D., . . . Glimcher, L. H. (2010). The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. Journal of Clinical Investigation, 120(7), 2457-2473

Jones, D., Glimcher, L. H., & Aliprantis, A. O. (2011). Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. Journal of Clinical Investigation, 121(7), 2534-2542

Jones, D. C., Wein, M. N., Oukka, M., Hofstaetter, J. G., Glimcher, M. J., & Glimcher, L. H. (2006). Regulation of adult bone mass by the zinc finger adapter protein schnurri-3. Science, 312(5777), 1223-1227

Wein, M. N., Jones, D. C., Shim, J. -., Aliprantis, A. O., Sulyanto, R., Lazarevic, V., . . . Glimcher, L. H. (2012). Control of bone resorption in mice by schnurri-3. Proceedings of the National Academy of Sciences of the United States of America, 109(21), 8173-8178

 

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Recommended Readings: Olaf Schneewind, M.D., Ph.D.

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Friday Lecture Series

Ernst A.H. Friedheim Memorial Lecture

Envelope Assembly and Function in Bacterial Pathogens

Olaf Schneewind, M.D., Ph.D.,

Louis Block Professor and chair, department of microbiology,

University of Chicago

November 11,  2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Cheng, A. G., M. McAdow, H. K. Kim, T. Bae, D. M. Missiakas, and O. Schneewind. 2010. Contribution of coagulases towards staphylococcus aureus disease and protective immunity. PLoS Pathogens 6, (8): 19-20

Hendrickx, A. P. A., J. M. Budzik, S. -Y Oh, and O. Schneewind. 2011. Architects at the bacterial surface-sortases and the assembly of pili with isopeptide bonds. Nature Reviews Microbiology 9, (3): 166-171

Kern, J., and O. Schneewind. 2010. BslA, the S-layer adhesin of B. anthracis, is a virulence factor for anthrax pathogenesis. Molecular microbiology 75, (2): 324-332

Kim, H. K., A. G. Cheng, H. -Y Kim, D. M. Missiakas, and O. Schneewind. 2010. Nontoxigenic protein A vaccine for methicillin-resistant staphylococcus aureus infections in mice. Journal of Experimental Medicine 207, (9): 1863-1870

Kim, H. K., A. DeDent, A. G. Cheng, M. McAdow, F. Bagnoli, D. M. Missiakas, and O. Schneewind. 2010. IsdA and IsdB antibodies protect mice against staphylococcus aureus abscess formation and lethal challenge. Vaccine 28, (38): 6382-6392

Schneewind, O., and D. Missiakas. 2011. Structural vaccinology to thwart antigenic variation in microbial pathogens. Proceedings of the National Academy of Sciences of the United States of America 108, (25): 10029-10030

Thammavongsa, V., J. W. Kern, D. M. Missiakas, and O. Schneewind. 2009. Staphylococcus aureus synthesizes adenosine to escape host immune responses. Journal of Experimental Medicine 206, (11): 2417-2427

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NAS Report Calls for Creation of a Biomedical Research and Patient Data Network

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WASHINGTON — A new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of disease and ultimately enhance diagnosis and treatment, says a new report from the National Research Council.  The “new taxonomy” that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms.  The report adds that the new data network could also improve biomedical research by enabling scientists to access patients’ information during treatment while still protecting their rights.  This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia.

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Recommended Readings: James E. Darnell Jr., M.D.

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Monday Lecture Series

JAK-STAT at 20: Where The Pathway Came From and Some Things I Still Hope to See Happen

James E. Darnell Jr., M.D., Vincent Astor Professor Emeritus and head,

Laboratory of Molecular Cell Biology,

The Rockefeller University

October 31,  2011

4:00 p.m.-5:00 p.m. (Refreshments, 3:45 p.m.-4:00 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Bromberg, J., and J. E. Darnell Jr. 2000. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19, (21): 2468-2473

Bromberg, J. F., M. H. Wrzeszczynska, G. Devgan, Y. Zhao, R. G. Pestell, C. Albanese, and J. E. Darnell Jr. 1999. Stat3 as an oncogene. Cell 98, (3): 295-303

Darnell Jr., J. E. 2005. Validating Stat3 in cancer therapy. Nature medicine 11, (6): 595-596

Levy, D. E., and J. E. Darnell Jr. 2002. STATs: Transcriptional control and biological impact. Nature Reviews Molecular Cell Biology 3, (9): 651-662

Mertens, C., and J. E. Darnell Jr. 2007. SnapShot: JAK-STAT signaling. Cell 131, (3): 612.e1-612.e2

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Recommended Readings: Rob Knight, Ph.D.

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Friday Lecture Series

Tools for Understanding the Human Microbiome

Rob Knight, Ph.D., early career scientist, Howard Hughes Medical Institute;

associate professor, department of chemistry and biochemistry,

University of Colorado, Boulder

October 28,  2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Recommended Readings:

Costello, E. K., C. L. Lauber, M. Hamady, N. Fierer, J. I. Gordon, and R. Knight. 2009. Bacterial community variation in human body habitats across space and time. Science 326, (5960): 1694-1697

Dominguez-Bello, M. G., E. K. Costello, M. Contreras, M. Magris, G. Hidalgo, N. Fierer, and R. Knight. 2010. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences of the United States of America 107, (26): 11971-11975

Kuczynski, J., Z. Liu, C. Lozupone, D. McDonald, N. Fierer, and R. Knight. 2010. Microbial community resemblance methods differ in their ability to detect biologically relevant patterns. Nature Methods 7, (10): 813-819

Turnbaugh, P. J., C. Quince, J. J. Faith, A. C. McHardy, T. Yatsunenko, F. Niazi, J. Affourtit, et al. 2010. Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins. Proceedings of the National Academy of Sciences of the United States of America 107, (16): 7503-7508

Turnbaugh, P. J., V. K. Ridaura, J. J. Faith, F. E. Rey, R. Knight, and J. I. Gordon. 2009. The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice. Science translational medicine 1, (6)

Vijay-Kumar, M., J. D. Aitken, F. A. Carvalho, T. C. Cullender, S. Mwangi, S. Srinivasan, S. V. Sitaraman, R. Knight, R. E. Ley, and A. T. Gewirtz. 2010. Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science 328, (5975): 228-231

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Fifty years ago at The Rockefeller Institute: Convocation 1961

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At its third academic convocation, held on June 16, 1961, The Rockefeller Institute conferred the degree of doctor of philosophy on ten of its students, among whom were the first women to be graduated from the Institute.

Each one of ten members of the faculty described a candidate’s intellectual progression and the way in which studies in many fields of science ultimately led him or her to seek new knowledge and understanding through research.

The graduands, their wives, and their parents were guests of President and Mrs. Bronk at a buffet supper before the traditional Ball for the students on the night preceding the conferring of degrees. Following the ceremonies, the Trustees were hosts to those who attended the convocation at a luncheon in Abby Aldrich Rockefeller Hall.

President Bronk paid tribute during the ceremonies to the colleges and universities in which the graduates had pursued their undergraduate studies: Amherst, Barnard, Bowdoin, Columbia, Dartmouth, Harvard, Massachusetts Institute of Technology, the University of Michigan, Oberlin, Reed, and Smith.

In recognition of their scholarly achievements and the noble example they have set for youthful scholars, the degree of doctor of science, honoris causa, was conferred on Dr. Thomas M. Rivers, Director Emeritus of the Institute, as well as on Dr. Hugh S. Taylor, Dean of the Graduate School, Emeritus, of Princeton University.

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Recommended Readings: Karel Svoboda, Ph.D.

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Friday Lecture Series

The Cortical Circuits Underlying Object Localization

Karel Svoboda, Ph.D., group leader, Janelia Farm Research Campus,

Howard Hughes Medical Institute

May 13, 2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Bureau, I., G. M. G. Shepherd, and K. Svoboda. 2008. Circuit and plasticity defects in the developing somatosensory cortex of Fmr1 knock-out mice. Journal of Neuroscience 28, (20): 5178-5188

Chen, B. E., J. T. Trachtenberg, A. J. G. D. Holtmaat, and K. Svoboda. 2008. Long-term, high-resolution imaging in the neocortex in vivo. Cold Spring Harbor Protocols 3, (1)

Holtmaat, A., L. Wilbrecht, G. W. Knott, E. Welker, and K. Svoboda. 2006. Experience-dependent and cell-type-specific spine growth in the neocortex. Nature 441, (7096): 979-983

Luo, L., E. M. Callaway, and K. Svoboda. 2008. Genetic dissection of neural circuits. Neuron 57, (5): 634-660

Petreanu, L., D. Huber, A. Sobczyk, and K. Svoboda. 2007. Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections. Nature neuroscience 10, (5): 663-668

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Recommended Readings: Loren Walensky, M.D., Ph.D.

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Friday Lecture Series

Dissecting the BCL-2 Family Interaction Network with Stapled Peptides:

Mechanistic Insights and Pharmacologic Opportunities

Loren Walensky, M.D., Ph.D., assistant professor, department of pediatrics, Harvard Medical School;

assistant professor, pediatric oncology, Dana-Farber Cancer Institute

May 6, 2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Braun, C. R., J. Mintseris, E. Gavathiotis, G. H. Bird, S. P. Gygi, and L. D. Walensky. 2010. Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. Chemistry and Biology 17, (12): 1325-1333

Kyoung, J. O., S. Barbuto, K. Pitter, J. Morash, L. D. Walensky, and S. J. Korsmeyer. 2006. A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro. Journal of Biological Chemistry 281, (48): 36999-37008

Letai, A., M. C. Bassik, L. D. Walensky, M. D. Sorcinelli, S. Weiler, and S. J. Korsmeyer. 2002. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2, (3): 183-192

Parra, M., P. Gascard, L. D. Walensky, J. A. Gimm, S. Blackshaw, N. Chan, Y. Takakuwa, et al. 2000. Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain. Journal of Biological Chemistry 275, (5): 3247-3255

Walensky, L. D. 2006. BCL-2 in the crosshairs: Tipping the balance of life and death. Cell death and differentiation 13, (8): 1339-1350

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Recommended Readings: Peter Vogt, Ph. D.

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Friday Lecture Series

Cancer Biology Lecture

Oncogenic Signaling in the PI3K Pathway

Peter Vogt, Ph.D., professor, department of molecular and experimental medicine,

The Scripps Research Institute

April 29, 2011

3:45 p.m.-5:00 p.m. (Refreshments, 3:15 p.m., Abby Lounge)

Caspary Auditorium

Bader, A. G., S. Kang, and P. K. Vogt. 2006. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proceedings of the National Academy of Sciences of the United States of America 103, (5): 1475-1479

Bader, A. G., S. Kang, L. Zhao, and P. K. Vogt. 2005. Oncogenic PI3K deregulates transcription and translation. Nature Reviews Cancer 5, (12): 921-929

Vogt, P. K., M. Gymnopoulos, and J. R. Hart. 2009. PI 3-kinase and cancer: Changing accents. Current Opinion in Genetics and Development 19, (1): 12-17

Vogt, P. K., S. Kang, M. -A Elsliger, and M. Gymnopoulos. 2007. Cancer-specific mutations in phosphatidylinositol 3-kinase. Trends in biochemical sciences 32, (7): 342-349

Zhao, L., and P. K. Vogt. 2008. Class I PI3K in oncogenic cellular transformation. Oncogene 27, (41): 5486-5496

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